New therapeutics beyond amyloid-β and tau for the treatment of Alzheimer’s disease
As the population ages, Alzheimer’s disease (AD), the most common neurodegenerative disease in elderly people, will impose social and economic burdens to the world. Currently approved drugs for the treatment of AD including cholinesterase inhibitors (donepezil, rivastigmine, and galantamine) and an...
Gespeichert in:
| Hauptverfasser: | , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
September 2021
|
| In: |
Acta pharmacologica Sinica
Year: 2021, Jahrgang: 42, Heft: 9, Pages: 1382-1389 |
| ISSN: | 1745-7254 |
| DOI: | 10.1038/s41401-020-00565-5 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/s41401-020-00565-5 Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/s41401-020-00565-5 
|
| Verfasserangaben: | Feng Zhang, Ru-jia Zhong, Cheng Cheng, Song Li and Wei-dong Le |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1882176065 | ||
| 003 | DE-627 | ||
| 005 | 20240307091418.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240229s2021 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1038/s41401-020-00565-5 |2 doi | |
| 035 | |a (DE-627)1882176065 | ||
| 035 | |a (DE-599)KXP1882176065 | ||
| 035 | |a (OCoLC)1425217405 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Zhang, Feng |e VerfasserIn |0 (DE-588)1268938548 |0 (DE-627)1817562088 |4 aut | |
| 245 | 1 | 0 | |a New therapeutics beyond amyloid-β and tau for the treatment of Alzheimer’s disease |c Feng Zhang, Ru-jia Zhong, Cheng Cheng, Song Li and Wei-dong Le |
| 246 | 3 | 3 | |a New therapeutics beyond amyloid-beta and tau for the treatment of Alzheimer’s disease |
| 264 | 1 | |c September 2021 | |
| 300 | |a 8 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Veröffentlicht: 02. Dezember 2020 | ||
| 500 | |a Gesehen am 29.02.2024 | ||
| 520 | |a As the population ages, Alzheimer’s disease (AD), the most common neurodegenerative disease in elderly people, will impose social and economic burdens to the world. Currently approved drugs for the treatment of AD including cholinesterase inhibitors (donepezil, rivastigmine, and galantamine) and an N-methyl-D-aspartic acid receptor antagonist (memantine) are symptomatic but poorly affect the progression of the disease. In recent decades, the concept of amyloid-β (Aβ) cascade and tau hyperphosphorylation leading to AD has dominated AD drug development. However, pharmacotherapies targeting Aβ and tau have limited success. It is generally believed that AD is caused by multiple pathological processes resulting from Aβ abnormality, tau phosphorylation, neuroinflammation, neurotransmitter dysregulation, and oxidative stress. In this review we updated the recent development of new therapeutics that regulate neurotransmitters, inflammation, lipid metabolism, autophagy, microbiota, circadian rhythm, and disease-modified genes for AD in preclinical research and clinical trials. It is to emphasize the importance of early diagnosis and multiple-target intervention, which may provide a promising outcome for AD treatment. | ||
| 650 | 4 | |a Biomedicine | |
| 650 | 4 | |a general | |
| 650 | 4 | |a Immunology | |
| 650 | 4 | |a Internal Medicine | |
| 650 | 4 | |a Medical Microbiology | |
| 650 | 4 | |a Pharmacology/Toxicology | |
| 650 | 4 | |a Vaccine | |
| 700 | 1 | |a Zhong, Rujia |d 1990- |e VerfasserIn |0 (DE-588)1222203634 |0 (DE-627)1741217113 |4 aut | |
| 700 | 1 | |a Cheng, Cheng |e VerfasserIn |4 aut | |
| 700 | 1 | |a Li, Song |e VerfasserIn |4 aut | |
| 700 | 1 | |a Le, Wei-dong |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Acta pharmacologica Sinica |d [Basingstoke] : Springer Nature, 1980 |g 42(2021), 9 vom: Sept., Seite 1382-1389 |h Online-Ressource |w (DE-627)354541250 |w (DE-600)2088565-9 |w (DE-576)263021335 |x 1745-7254 |7 nnas |a New therapeutics beyond amyloid-β and tau for the treatment of Alzheimer’s disease |
| 773 | 1 | 8 | |g volume:42 |g year:2021 |g number:9 |g month:09 |g pages:1382-1389 |g extent:8 |a New therapeutics beyond amyloid-β and tau for the treatment of Alzheimer’s disease |
| 856 | 4 | 0 | |u https://doi.org/10.1038/s41401-020-00565-5 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.nature.com/articles/s41401-020-00565-5 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20240229 | ||
| 993 | |a Article | ||
| 994 | |a 2021 | ||
| 998 | |g 1222203634 |a Zhong, Rujia |m 1222203634:Zhong, Rujia |d 60000 |d 61000 |e 60000PZ1222203634 |e 61000PZ1222203634 |k 0/60000/ |k 1/60000/61000/ |p 2 | ||
| 998 | |g 1268938548 |a Zhang, Feng |m 1268938548:Zhang, Feng |d 60000 |d 61000 |e 60000PZ1268938548 |e 61000PZ1268938548 |k 0/60000/ |k 1/60000/61000/ |p 1 |x j | ||
| 999 | |a KXP-PPN1882176065 |e 4494134392 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"note":["Veröffentlicht: 02. Dezember 2020","Gesehen am 29.02.2024"],"title":[{"title":"New therapeutics beyond amyloid-β and tau for the treatment of Alzheimer’s disease","title_sort":"New therapeutics beyond amyloid-β and tau for the treatment of Alzheimer’s disease"}],"person":[{"role":"aut","family":"Zhang","given":"Feng","display":"Zhang, Feng"},{"role":"aut","display":"Zhong, Rujia","given":"Rujia","family":"Zhong"},{"family":"Cheng","given":"Cheng","display":"Cheng, Cheng","role":"aut"},{"family":"Li","given":"Song","display":"Li, Song","role":"aut"},{"role":"aut","family":"Le","given":"Wei-dong","display":"Le, Wei-dong"}],"origin":[{"dateIssuedKey":"2021","dateIssuedDisp":"September 2021"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"titleAlt":[{"title":"New therapeutics beyond amyloid-beta and tau for the treatment of Alzheimer’s disease"}],"physDesc":[{"extent":"8 S."}],"language":["eng"],"id":{"doi":["10.1038/s41401-020-00565-5"],"eki":["1882176065"]},"recId":"1882176065","name":{"displayForm":["Feng Zhang, Ru-jia Zhong, Cheng Cheng, Song Li and Wei-dong Le"]},"relHost":[{"language":["eng","chi"],"disp":"New therapeutics beyond amyloid-β and tau for the treatment of Alzheimer’s diseaseActa pharmacologica Sinica","physDesc":[{"extent":"Online-Ressource"}],"part":{"text":"42(2021), 9 vom: Sept., Seite 1382-1389","year":"2021","issue":"9","extent":"8","volume":"42","pages":"1382-1389"},"titleAlt":[{"title":"APS"},{"title":"Acta pharmacologica Sinica / Chinese Pharmacological Society"}],"name":{"displayForm":["Chinese Pharmacological Society"]},"recId":"354541250","id":{"eki":["354541250"],"zdb":["2088565-9"],"issn":["1745-7254"],"doi":["10.1111/(ISSN)1745-7254"]},"note":["Gesehen am 07.07.2023","China-Zeitschriften-Code: CN31-1347","CAJ control code: ZGLL"],"origin":[{"dateIssuedKey":"1980","dateIssuedDisp":"1980-","publisherPlace":"[Basingstoke] ; Shang hai shi ; Beijing ; Oxford ; Oxford ; [London]","publisher":"Springer Nature ; [Verlag nicht ermittelbar] ; Science Press ; Blackwell ; Wiley-Blackwell ; Nature Publishing Group"}],"type":{"bibl":"periodical","media":"Online-Ressource"},"title":[{"subtitle":"APS","title_sort":"Acta pharmacologica Sinica","title":"Acta pharmacologica Sinica"}],"pubHistory":["1.1980 -"]}]} | ||
| SRT | |a ZHANGFENGZNEWTHERAPE2021 | ||