Psilocybin does not induce the vulnerability marker HSP70 in neurons susceptible to Olney’s lesions
S-ketamine, a N-methyl-D-aspartate receptor (NMDAR) antagonist, and psilocybin, a 5-hydroxy-tryptamine (serotonin) 2A receptor (5-HT2AR) agonist, are reported as effective rapid-acting antidepressants. Both compounds increase glutamate signalling and evoke cortical hyperexcitation. S-ketamine induce...
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| Main Authors: | , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
07 November 2023
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| In: |
European archives of psychiatry and clinical neuroscience
Year: 2024, Volume: 274, Issue: 4, Pages: 1013-1019 |
| ISSN: | 1433-8491 |
| DOI: | 10.1007/s00406-023-01699-3 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.1007/s00406-023-01699-3 Verlag, kostenfrei, Volltext: https://link.springer.com/article/10.1007/s00406-023-01699-3 
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| Author Notes: | Ana-Maria Iorgu, Andrei-Nicolae Vasilescu, Natascha Pfeiffer, Rainer Spanagel, Anne Stephanie Mallien, Dragos Inta, Peter Gass |
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| 245 | 1 | 0 | |a Psilocybin does not induce the vulnerability marker HSP70 in neurons susceptible to Olney’s lesions |c Ana-Maria Iorgu, Andrei-Nicolae Vasilescu, Natascha Pfeiffer, Rainer Spanagel, Anne Stephanie Mallien, Dragos Inta, Peter Gass |
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| 520 | |a S-ketamine, a N-methyl-D-aspartate receptor (NMDAR) antagonist, and psilocybin, a 5-hydroxy-tryptamine (serotonin) 2A receptor (5-HT2AR) agonist, are reported as effective rapid-acting antidepressants. Both compounds increase glutamate signalling and evoke cortical hyperexcitation. S-ketamine induces neurotoxicity especially in the retrosplenial cortex (Olney’s lesions). Whether psilocybin produces similar neurotoxic effects has so far not been investigated. We performed an immunohistochemical whole-brain mapping for heat shock protein 70 (HSP70) in rats treated with psilocybin, S-ketamine, and MK-801. In contrast to S-ketamine- and MK-801-treated animals, we did not detect any HSP70-positive neurons in retrosplenial cortex of rats treated with psilocybin. Our results suggest that psilocybin might be safer for clinical use compared to S-ketamine regarding neuronal damage. | ||
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