Predictive value of DNA methylation patterns in AML patients treated with an azacytidine containing induction regimen
Acute myeloid leukemia (AML) is a heterogeneous disease with a poor prognosis. Dysregulation of the epigenetic machinery is a significant contributor to disease development. Some AML patients benefit from treatment with hypomethylating agents (HMAs), but no predictive biomarkers for therapy response...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
26 October 2023
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| In: |
Clinical epigenetics
Year: 2023, Volume: 15, Pages: 1-16 |
| ISSN: | 1868-7083 |
| DOI: | 10.1186/s13148-023-01580-z |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s13148-023-01580-z Verlag, kostenfrei, Volltext: https://clinicalepigeneticsjournal.biomedcentral.com/articles/10.1186/s13148-023-01580-z 
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| Author Notes: | Maximilian Schmutz, Manuela Zucknick, Richard F. Schlenk, Daniel Mertens, Axel Benner, Dieter Weichenhan, Oliver Mücke, Konstanze Döhner, Christoph Plass, Lars Bullinger and Rainer Claus |
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| 520 | |a Acute myeloid leukemia (AML) is a heterogeneous disease with a poor prognosis. Dysregulation of the epigenetic machinery is a significant contributor to disease development. Some AML patients benefit from treatment with hypomethylating agents (HMAs), but no predictive biomarkers for therapy response exist. Here, we investigated whether unbiased genome-wide assessment of pre-treatment DNA-methylation profiles in AML bone marrow blasts can help to identify patients who will achieve a remission after an azacytidine-containing induction regimen. | ||
| 650 | 4 | |a AML | |
| 650 | 4 | |a Azacytidine | |
| 650 | 4 | |a DNA methylation patterns | |
| 650 | 4 | |a DNA-methylation | |
| 650 | 4 | |a Epigenetics | |
| 650 | 4 | |a HMA-treatment | |
| 650 | 4 | |a Predictive biomarker | |
| 650 | 4 | |a Predictive signature | |
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