Buchumschlag

Predictive value of DNA methylation patterns in AML patients treated with an azacytidine containing induction regimen

Acute myeloid leukemia (AML) is a heterogeneous disease with a poor prognosis. Dysregulation of the epigenetic machinery is a significant contributor to disease development. Some AML patients benefit from treatment with hypomethylating agents (HMAs), but no predictive biomarkers for therapy response...

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Bibliographische Detailangaben
Hauptverfasser: Schmutz, Maximilian (VerfasserIn) , Zucknick, Manuela (VerfasserIn) , Schlenk, Richard Friedrich (VerfasserIn) , Mertens, Daniel (VerfasserIn) , Benner, Axel (VerfasserIn) , Weichenhan, Dieter (VerfasserIn) , Mücke, Oliver (VerfasserIn) , Döhner, Konstanze (VerfasserIn) , Plass, Christoph (VerfasserIn) , Bullinger, Lars (VerfasserIn) , Claus, Rainer (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 26 October 2023
In: Clinical epigenetics
Year: 2023, Jahrgang: 15, Pages: 1-16
ISSN:1868-7083
DOI:10.1186/s13148-023-01580-z
Online-Zugang:Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s13148-023-01580-z
Verlag, kostenfrei, Volltext: https://clinicalepigeneticsjournal.biomedcentral.com/articles/10.1186/s13148-023-01580-z
Volltext
Verfasserangaben:Maximilian Schmutz, Manuela Zucknick, Richard F. Schlenk, Daniel Mertens, Axel Benner, Dieter Weichenhan, Oliver Mücke, Konstanze Döhner, Christoph Plass, Lars Bullinger and Rainer Claus
Beschreibung
Zusammenfassung:Acute myeloid leukemia (AML) is a heterogeneous disease with a poor prognosis. Dysregulation of the epigenetic machinery is a significant contributor to disease development. Some AML patients benefit from treatment with hypomethylating agents (HMAs), but no predictive biomarkers for therapy response exist. Here, we investigated whether unbiased genome-wide assessment of pre-treatment DNA-methylation profiles in AML bone marrow blasts can help to identify patients who will achieve a remission after an azacytidine-containing induction regimen.
Beschreibung:Gesehen am 05.03.2024
Beschreibung:Online Resource
ISSN:1868-7083
DOI:10.1186/s13148-023-01580-z

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