Myt1l haploinsufficiency leads to obesity and multifaceted behavioral alterations in mice
The zinc finger domain containing transcription factor Myt1l is tightly associated with neuronal identity and is the only transcription factor known that is both neuron-specific and expressed in all neuronal subtypes. We identified Myt1l as a powerful reprogramming factor that, in combination with t...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
10 May 2022
|
| In: |
Molecular autism
Year: 2022, Jahrgang: 13, Pages: 1-28 |
| ISSN: | 2040-2392 |
| DOI: | 10.1186/s13229-022-00497-3 |
| Online-Zugang: | Resolving-System, kostenfrei, Volltext: https://doi.org/10.1186/s13229-022-00497-3 Verlag, kostenfrei, Volltext: https://molecularautism.biomedcentral.com/articles/10.1186/s13229-022-00497-3 
|
| Verfasserangaben: | Markus Wöhr, Wendy M. Fong, Justyna A. Janas, Moritz Mall, Christian Thome, Madhuri Vangipuram, Lingjun Meng, Thomas C. Südhof, Marius Wernig |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1883095638 | ||
| 003 | DE-627 | ||
| 005 | 20260112114333.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240311s2022 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1186/s13229-022-00497-3 |2 doi | |
| 035 | |a (DE-627)1883095638 | ||
| 035 | |a (DE-599)KXP1883095638 | ||
| 035 | |a (OCoLC)1443645287 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Wöhr, Markus |d 1980- |e VerfasserIn |0 (DE-588)136353606 |0 (DE-627)581097491 |0 (DE-576)300977344 |4 aut | |
| 245 | 1 | 0 | |a Myt1l haploinsufficiency leads to obesity and multifaceted behavioral alterations in mice |c Markus Wöhr, Wendy M. Fong, Justyna A. Janas, Moritz Mall, Christian Thome, Madhuri Vangipuram, Lingjun Meng, Thomas C. Südhof, Marius Wernig |
| 264 | 1 | |c 10 May 2022 | |
| 300 | |a 28 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 11.03.2024 | ||
| 520 | |a The zinc finger domain containing transcription factor Myt1l is tightly associated with neuronal identity and is the only transcription factor known that is both neuron-specific and expressed in all neuronal subtypes. We identified Myt1l as a powerful reprogramming factor that, in combination with the proneural bHLH factor Ascl1, could induce neuronal fate in fibroblasts. Molecularly, we found it to repress many non-neuronal gene programs, explaining its supportive role to induce and safeguard neuronal identity in combination with proneural bHLH transcriptional activators. Moreover, human genetics studies found MYT1L mutations to cause intellectual disability and autism spectrum disorder often coupled with obesity. | ||
| 650 | 4 | |a Autism | |
| 650 | 4 | |a Obesity | |
| 650 | 4 | |a Social behavior | |
| 650 | 4 | |a Transcription factor | |
| 650 | 4 | |a Ultrasonic vocalization | |
| 700 | 1 | |a Fong, Wendy M. |e VerfasserIn |4 aut | |
| 700 | 1 | |8 1\p |a Janas, Justyna |e VerfasserIn |0 (DE-588)1310767475 |0 (DE-627)1870880412 |4 aut | |
| 700 | 1 | |a Mall, Moritz |e VerfasserIn |0 (DE-588)1168277477 |0 (DE-627)1031930213 |0 (DE-576)511500866 |4 aut | |
| 700 | 1 | |8 2\p |a Thome, Christian |e VerfasserIn |0 (DE-588)1058750402 |0 (DE-627)797487514 |0 (DE-576)41488275X |4 aut | |
| 700 | 1 | |a Vangipuram, Madhuri |e VerfasserIn |4 aut | |
| 700 | 1 | |a Meng, Lingjun |e VerfasserIn |4 aut | |
| 700 | 1 | |a Südhof, Thomas C. |d 1955- |e VerfasserIn |0 (DE-588)1042645108 |0 (DE-627)76916496X |0 (DE-576)275946630 |4 aut | |
| 700 | 1 | |a Wernig, Marius |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Molecular autism |d London : BioMed Central, 2010 |g 13(2022), Artikel-ID 19, Seite 1-28 |h Online-Ressource |w (DE-627)620141522 |w (DE-600)2540930-X |w (DE-576)31942829X |x 2040-2392 |7 nnas |a Myt1l haploinsufficiency leads to obesity and multifaceted behavioral alterations in mice |
| 773 | 1 | 8 | |g volume:13 |g year:2022 |g elocationid:19 |g pages:1-28 |g extent:28 |a Myt1l haploinsufficiency leads to obesity and multifaceted behavioral alterations in mice |
| 787 | 0 | 8 | |i Errata |a Wöhr, Markus, 1980 - |t Correction to: Myt1l haploinsufficiency leads to obesity and multifaceted behavioral alterations in mice |d 2025 |w (DE-627)1948461501 |
| 856 | 4 | 0 | |u https://doi.org/10.1186/s13229-022-00497-3 |x Resolving-System |x Verlag |z kostenfrei |3 Volltext |7 0 |
| 856 | 4 | 0 | |u https://molecularautism.biomedcentral.com/articles/10.1186/s13229-022-00497-3 |x Verlag |z kostenfrei |3 Volltext |7 0 |
| 883 | |8 1\p |a cgwrk |d 20241001 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 883 | |8 2\p |a cgwrk |d 20241001 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 951 | |a AR | ||
| 992 | |a 20240311 | ||
| 993 | |a Article | ||
| 994 | |a 2022 | ||
| 998 | |g 1168277477 |a Mall, Moritz |m 1168277477:Mall, Moritz |d 140000 |e 140000PM1168277477 |k 0/140000/ |p 4 | ||
| 999 | |a KXP-PPN1883095638 |e 4499179084 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"note":["Gesehen am 11.03.2024"],"id":{"eki":["1883095638"],"doi":["10.1186/s13229-022-00497-3"]},"relHost":[{"part":{"extent":"28","volume":"13","year":"2022","text":"13(2022), Artikel-ID 19, Seite 1-28","pages":"1-28"},"language":["eng"],"origin":[{"dateIssuedKey":"2010","publisherPlace":"London","publisher":"BioMed Central","dateIssuedDisp":"2010-"}],"title":[{"title_sort":"Molecular autism","title":"Molecular autism"}],"pubHistory":["1.2010 -"],"note":["Gesehen am 13.12.11"],"id":{"zdb":["2540930-X"],"eki":["620141522"],"issn":["2040-2392"]},"recId":"620141522","disp":"Myt1l haploinsufficiency leads to obesity and multifaceted behavioral alterations in miceMolecular autism","type":{"media":"Online-Ressource","bibl":"periodical"},"physDesc":[{"extent":"Online-Ressource"}]}],"name":{"displayForm":["Markus Wöhr, Wendy M. Fong, Justyna A. Janas, Moritz Mall, Christian Thome, Madhuri Vangipuram, Lingjun Meng, Thomas C. Südhof, Marius Wernig"]},"language":["eng"],"recId":"1883095638","type":{"media":"Online-Ressource","bibl":"article-journal"},"origin":[{"dateIssuedDisp":"10 May 2022","dateIssuedKey":"2022"}],"person":[{"family":"Wöhr","display":"Wöhr, Markus","role":"aut","roleDisplay":"VerfasserIn","given":"Markus"},{"roleDisplay":"VerfasserIn","given":"Wendy M.","role":"aut","display":"Fong, Wendy M.","family":"Fong"},{"family":"Janas","display":"Janas, Justyna","role":"aut","given":"Justyna","roleDisplay":"VerfasserIn"},{"role":"aut","given":"Moritz","roleDisplay":"VerfasserIn","family":"Mall","display":"Mall, Moritz"},{"display":"Thome, Christian","family":"Thome","roleDisplay":"VerfasserIn","given":"Christian","role":"aut"},{"family":"Vangipuram","display":"Vangipuram, Madhuri","given":"Madhuri","roleDisplay":"VerfasserIn","role":"aut"},{"given":"Lingjun","roleDisplay":"VerfasserIn","role":"aut","display":"Meng, Lingjun","family":"Meng"},{"role":"aut","given":"Thomas C.","roleDisplay":"VerfasserIn","display":"Südhof, Thomas C.","family":"Südhof"},{"role":"aut","given":"Marius","roleDisplay":"VerfasserIn","family":"Wernig","display":"Wernig, Marius"}],"physDesc":[{"extent":"28 S."}],"title":[{"title_sort":"Myt1l haploinsufficiency leads to obesity and multifaceted behavioral alterations in mice","title":"Myt1l haploinsufficiency leads to obesity and multifaceted behavioral alterations in mice"}]} | ||
| SRT | |a WOEHRMARKUMYT1LHAPLO1020 | ||