Initial results with (18F)FAPI‑74 PET/CT in idiopathic pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF) is a chronic fibrosing interstitial lung disease with a poor prognosis. Ga-68-labeled FAP ligands exhibited highly promising results due to the crucial role of activated fibroblasts in fibrosis imaging of the lung. However, F-18-labeled FAP ligands might provide q...
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| Hauptverfasser: | , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
20 December 2023
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| In: |
European journal of nuclear medicine and molecular imaging
Year: 2024, Jahrgang: 51, Heft: 6, Pages: 1605-1611 |
| ISSN: | 1619-7089 |
| DOI: | 10.1007/s00259-023-06564-y |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1007/s00259-023-06564-y Verlag, kostenfrei, Volltext: https://link.springer.com/article/10.1007/s00259-023-06564-y 
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| Verfasserangaben: | Yuriko Mori, Vasko Kramer, Emil Novruzov, Eduards Mamlins, Manuel Roehrich, Rene Fernandez, Horacio Amaral, Cristian Soza-Ried, Barbara Monje, Eduardo Sabbagh, Matias Florenzano, Frederik L. Giesel & Alvaro Undurraga |
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| 245 | 1 | 0 | |a Initial results with (18F)FAPI‑74 PET/CT in idiopathic pulmonary fibrosis |c Yuriko Mori, Vasko Kramer, Emil Novruzov, Eduards Mamlins, Manuel Roehrich, Rene Fernandez, Horacio Amaral, Cristian Soza-Ried, Barbara Monje, Eduardo Sabbagh, Matias Florenzano, Frederik L. Giesel & Alvaro Undurraga |
| 246 | 3 | 3 | |a Initial results with (18 F)FAPI‑74 PET/CT in idiopathic pulmonary fibrosis |
| 264 | 1 | |c 20 December 2023 | |
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| 520 | |a Idiopathic pulmonary fibrosis (IPF) is a chronic fibrosing interstitial lung disease with a poor prognosis. Ga-68-labeled FAP ligands exhibited highly promising results due to the crucial role of activated fibroblasts in fibrosis imaging of the lung. However, F-18-labeled FAP ligands might provide qualitatively much higher imaging results with accompanying economic benefits due to large-scale production. Thus, we sought to investigate the potential of [F-18]FAPI-74 prospectively in a small patient cohort.Methods: Eight patients underwent both [F-18]FAPI-74-PET/CT and HRCT scans and were then compared with a control group without any fibrosing pulmonary disease. The tracer uptake of fibrotic lung areas was analyzed in synopsis with radiological and clinical parameters.Results: We observed a positive correlation between the fibrotic active volume, the Hounsfield scale, as well as the vital and diffusing capacity of the lung.Conclusion: The initial results confirm our assumption that [F-18]FAPI-74 offers a viable non-invasive assessment method for pulmonary fibrotic changes in patients with IPF. | ||
| 650 | 4 | |a FAPI | |
| 650 | 4 | |a Fibroblast activation protein | |
| 650 | 4 | |a Fibrosis | |
| 650 | 4 | |a Idiopathic pulmonary disease | |
| 650 | 4 | |a PET | |
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