Reduced vagal activity in borderline personality disorder is unaffected by intranasal oxytocin administration, but predicted by the interaction between childhood trauma and attachment insecurity: psychiatry and preclinical psychiatric studies
Individuals with borderline personality disorder (BPD) show self-regulatory deficits, associated with reduced heart-rate variability (HRV). However, results on reduced HRV in BPD remain heterogeneous, thus encouraging the search for developmental constructs explaining this heterogeneity. The present...
Gespeichert in:
| Hauptverfasser: | , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
11 March 2022
|
| In: |
Journal of neural transmission
Year: 2022, Jahrgang: 129, Heft: 4, Pages: 409-419 |
| ISSN: | 1435-1463 |
| DOI: | 10.1007/s00702-022-02482-9 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1007/s00702-022-02482-9 Verlag, kostenfrei, Volltext: https://link.springer.com/article/10.1007/s00702-022-02482-9 
|
| Verfasserangaben: | Sarah N. Back, Marius Schmitz, Julian Koenig, Max Zettl, Nikolaus Kleindienst, Sabine C. Herpertz, Katja Bertsch |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1883135052 | ||
| 003 | DE-627 | ||
| 005 | 20240703152510.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240312s2022 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s00702-022-02482-9 |2 doi | |
| 035 | |a (DE-627)1883135052 | ||
| 035 | |a (DE-599)KXP1883135052 | ||
| 035 | |a (OCoLC)1443645131 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 11 |2 sdnb | ||
| 100 | 1 | |a Back, Sarah Naomi |d 1996- |e VerfasserIn |0 (DE-588)1244175293 |0 (DE-627)1775129225 |4 aut | |
| 245 | 1 | 0 | |a Reduced vagal activity in borderline personality disorder is unaffected by intranasal oxytocin administration, but predicted by the interaction between childhood trauma and attachment insecurity |b psychiatry and preclinical psychiatric studies |c Sarah N. Back, Marius Schmitz, Julian Koenig, Max Zettl, Nikolaus Kleindienst, Sabine C. Herpertz, Katja Bertsch |
| 264 | 1 | |c 11 March 2022 | |
| 300 | |a 11 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 12.03.2024 | ||
| 520 | |a Individuals with borderline personality disorder (BPD) show self-regulatory deficits, associated with reduced heart-rate variability (HRV). However, results on reduced HRV in BPD remain heterogeneous, thus encouraging the search for developmental constructs explaining this heterogeneity. The present study first examined predictors of reduced resting-state HRV in BPD, namely the interaction between self-reported adult attachment insecurity and childhood trauma. Second, we investigated if alterations in resting-state HRV are modified by intranasal oxytocin administration, as oxytocin may enhance HRV and is implicated in the interaction between childhood trauma and disturbed attachment for the pathogenesis of BPD. In a randomized, placebo-controlled trial, 53 unmedicated women with BPD and 60 healthy controls (HC) self-administered either 24 I.U. of oxytocin or placebo and underwent a 4-min electrocardiogram. Our results replicate significantly reduced HRV in women with BPD, explained up to 16% by variations in childhood trauma and attachment insecurity. At high levels of acute attachment insecurity, higher levels of childhood trauma significantly predicted reduced HRV in BPD. However, our results do not support a significant effect of oxytocin on mean HRV, and no interaction effect emerged including childhood trauma and attachment insecurity. Our findings highlight a complex interaction between reduced vagal activity and developmental factors in BPD. | ||
| 650 | 4 | |a Attachment | |
| 650 | 4 | |a Borderline personality disorder | |
| 650 | 4 | |a Childhood trauma | |
| 650 | 4 | |a Early life adversity | |
| 650 | 4 | |a Heart-rate variability | |
| 650 | 4 | |a Oxytocin | |
| 650 | 4 | |a Vagal activity | |
| 700 | 1 | |a Schmitz, Marius |d 1992- |e VerfasserIn |0 (DE-588)1169100449 |0 (DE-627)1032740914 |0 (DE-576)511928858 |4 aut | |
| 700 | 1 | |a Koenig, Julian |d 1985- |e VerfasserIn |0 (DE-588)1031388052 |0 (DE-627)736334459 |0 (DE-576)378827227 |4 aut | |
| 700 | 1 | |a Zettl, Max |d 1995- |e VerfasserIn |0 (DE-588)1202570615 |0 (DE-627)1686940106 |4 aut | |
| 700 | 1 | |a Kleindienst, Nikolaus |d 1965- |e VerfasserIn |0 (DE-588)129283622 |0 (DE-627)392389053 |0 (DE-576)297578340 |4 aut | |
| 700 | 1 | |a Herpertz, Sabine |d 1960- |e VerfasserIn |0 (DE-588)132328526 |0 (DE-627)520581113 |0 (DE-576)182985261 |4 aut | |
| 700 | 1 | |a Bertsch, Katja |d 1981- |e VerfasserIn |0 (DE-588)141519568 |0 (DE-627)629442355 |0 (DE-576)324253478 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of neural transmission |d Wien [u.a.] : Springer, 1950 |g 129(2022), 4 vom: Apr., Seite 409-419 |h Online-Ressource |w (DE-627)300185901 |w (DE-600)1481655-6 |w (DE-576)09450542X |x 1435-1463 |7 nnas |a Reduced vagal activity in borderline personality disorder is unaffected by intranasal oxytocin administration, but predicted by the interaction between childhood trauma and attachment insecurity psychiatry and preclinical psychiatric studies |
| 773 | 1 | 8 | |g volume:129 |g year:2022 |g number:4 |g month:04 |g pages:409-419 |g extent:11 |a Reduced vagal activity in borderline personality disorder is unaffected by intranasal oxytocin administration, but predicted by the interaction between childhood trauma and attachment insecurity psychiatry and preclinical psychiatric studies |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00702-022-02482-9 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u https://link.springer.com/article/10.1007/s00702-022-02482-9 |x Verlag |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20240312 | ||
| 993 | |a Article | ||
| 994 | |a 2022 | ||
| 998 | |g 141519568 |a Bertsch, Katja |m 141519568:Bertsch, Katja |d 910000 |d 910600 |d 100000 |e 910000PB141519568 |e 910600PB141519568 |e 100000PB141519568 |k 0/910000/ |k 1/910000/910600/ |k 0/100000/ |p 7 |y j | ||
| 998 | |g 132328526 |a Herpertz, Sabine |m 132328526:Herpertz, Sabine |d 910000 |d 910600 |e 910000PH132328526 |e 910600PH132328526 |k 0/910000/ |k 1/910000/910600/ |p 6 | ||
| 998 | |g 129283622 |a Kleindienst, Nikolaus |m 129283622:Kleindienst, Nikolaus |d 60000 |e 60000PK129283622 |k 0/60000/ |p 5 | ||
| 998 | |g 1202570615 |a Zettl, Max |m 1202570615:Zettl, Max |d 910000 |d 910600 |e 910000PZ1202570615 |e 910600PZ1202570615 |k 0/910000/ |k 1/910000/910600/ |p 4 | ||
| 998 | |g 1031388052 |a Koenig, Julian |m 1031388052:Koenig, Julian |d 50000 |e 50000PK1031388052 |k 0/50000/ |p 3 | ||
| 998 | |g 1169100449 |a Schmitz, Marius |m 1169100449:Schmitz, Marius |d 910000 |d 910600 |e 910000PS1169100449 |e 910600PS1169100449 |k 0/910000/ |k 1/910000/910600/ |p 2 | ||
| 999 | |a KXP-PPN1883135052 |e 4499267099 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"id":{"doi":["10.1007/s00702-022-02482-9"],"eki":["1883135052"]},"name":{"displayForm":["Sarah N. Back, Marius Schmitz, Julian Koenig, Max Zettl, Nikolaus Kleindienst, Sabine C. Herpertz, Katja Bertsch"]},"physDesc":[{"extent":"11 S."}],"recId":"1883135052","language":["eng"],"type":{"media":"Online-Ressource","bibl":"article-journal"},"note":["Gesehen am 12.03.2024"],"title":[{"subtitle":"psychiatry and preclinical psychiatric studies","title_sort":"Reduced vagal activity in borderline personality disorder is unaffected by intranasal oxytocin administration, but predicted by the interaction between childhood trauma and attachment insecurity","title":"Reduced vagal activity in borderline personality disorder is unaffected by intranasal oxytocin administration, but predicted by the interaction between childhood trauma and attachment insecurity"}],"origin":[{"dateIssuedDisp":"11 March 2022","dateIssuedKey":"2022"}],"relHost":[{"id":{"zdb":["1481655-6"],"issn":["1435-1463"],"eki":["300185901"]},"part":{"pages":"409-419","issue":"4","text":"129(2022), 4 vom: Apr., Seite 409-419","extent":"11","year":"2022","volume":"129"},"titleAlt":[{"title":"Acta neurovegetativa"},{"title":"Journal of neuro-visceral relations"},{"title":"Journal of neural transmission / General section"}],"pubHistory":["1.1950 -"],"corporate":[{"role":"isb","display":"European Society for Clinical Neuropharmacology"}],"title":[{"title":"Journal of neural transmission","title_sort":"Journal of neural transmission"}],"type":{"bibl":"periodical","media":"Online-Ressource"},"language":["eng"],"note":["Gesehen am 18.10.05"],"origin":[{"publisherPlace":"Wien [u.a.]","dateIssuedKey":"1950","dateIssuedDisp":"1950-","publisher":"Springer"}],"disp":"Reduced vagal activity in borderline personality disorder is unaffected by intranasal oxytocin administration, but predicted by the interaction between childhood trauma and attachment insecurity psychiatry and preclinical psychiatric studiesJournal of neural transmission","recId":"300185901","physDesc":[{"extent":"Online-Ressource"}]}],"person":[{"family":"Back","given":"Sarah Naomi","role":"aut","display":"Back, Sarah Naomi"},{"role":"aut","given":"Marius","family":"Schmitz","display":"Schmitz, Marius"},{"display":"Koenig, Julian","family":"Koenig","role":"aut","given":"Julian"},{"family":"Zettl","given":"Max","role":"aut","display":"Zettl, Max"},{"display":"Kleindienst, Nikolaus","family":"Kleindienst","given":"Nikolaus","role":"aut"},{"display":"Herpertz, Sabine","given":"Sabine","role":"aut","family":"Herpertz"},{"display":"Bertsch, Katja","given":"Katja","role":"aut","family":"Bertsch"}]} | ||
| SRT | |a BACKSARAHNREDUCEDVAG1120 | ||