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Tissue microarray analyses suggest axl as a predictive biomarker in HPV-negative head and neck cancer

The receptor tyrosine kinase Axl is described to promote migration, metastasis and resistance against molecular targeting, radiotherapy, and chemotherapy in various tumor entities, including head and neck squamous cell carcinoma (HNSCC). Since clinical data on Axl and its ligand Gas6 in HNSCC are sp...

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Main Authors: Busch, Chia-Jung (Author) , Hagel, Christian (Author) , Becker, Benjamin (Author) , Oetting, Agnes (Author) , Möckelmann, Nikolaus (Author) , Droste, Conrad (Author) , Möller-Koop, Christina (Author) , Witt, Melanie (Author) , Blaurock, Markus (Author) , Loges, Sonja (Author) , Rothkamm, Kai (Author) , Betz, Christian (Author) , Münscher, Adrian (Author) , Clauditz, Till S. (Author) , Rieckmann, Thorsten (Author)
Format: Article (Journal)
Language:English
Published: 5 April 2022
In: Cancers
Year: 2022, Volume: 14, Issue: 7, Pages: 1-13
ISSN:2072-6694
DOI:10.3390/cancers14071829
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.3390/cancers14071829
Verlag, kostenfrei, Volltext: https://www.mdpi.com/2072-6694/14/7/1829
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Author Notes:Chia-Jung Busch, Christian Hagel, Benjamin Becker, Agnes Oetting, Nikolaus Möckelmann, Conrad Droste, Christina Möller-Koop, Melanie Witt, Markus Blaurock, Sonja Loges, Kai Rothkamm, Christian Betz, Adrian Münscher, Till S. Clauditz and Thorsten Rieckmann
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Summary:The receptor tyrosine kinase Axl is described to promote migration, metastasis and resistance against molecular targeting, radiotherapy, and chemotherapy in various tumor entities, including head and neck squamous cell carcinoma (HNSCC). Since clinical data on Axl and its ligand Gas6 in HNSCC are sparse, we assessed the association of Axl and Gas6 expression with patient survival in a single center retrospective cohort in a tissue microarray format. Expression was evaluated manually using an established algorithm and correlated with clinicopathological parameters and patient survival. A number of 362 samples yielded interpretable staining, which did not correlate with T- and N-stage. Protein expression levels were not associated with the survival of patients with p16-positive oropharyngeal SCC. In HPV-negative tumors, Axl expression did not impact patients treated with primary or adjuvant radio(chemo)therapy, but was significantly associated with inferior overall and recurrence-free survival in patients treated with surgery alone. Gas6 was a positive predictor of survival in patients whose treatment included radiotherapy. Associations remained significant in multivariable analysis. Our data question a meaningful contribution of the Axl/Gas6 pathway to radio-resistance in HNSCC and instead suggest that strong Axl expression identifies tumors requiring adjuvant radio(chemo)therapy after surgery.
Item Description:Dieser Artikel gehört zum Special issue: Predictive biomarkers for treatment response for head and neck cancers
Gesehen am 12.03.2024
Physical Description:Online Resource
ISSN:2072-6694
DOI:10.3390/cancers14071829

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