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Editorial: neurotrauma and repair: from peripheral to central nerve injury

Neurotrauma, encompassing traumatic brain injury (TBI), peripheral nerve injury (PNI), and spinal cord injury (SCI), continues to be a major global public health concern. The complex pathophysiological mechanisms and lifelong neurological deficits associated with neurotrauma emphasize the urgent nee...

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1. Verfasser: Younsi, Alexander (VerfasserIn)
Dokumenttyp: Article (Journal) Editorial
Sprache:Englisch
Veröffentlicht: 01 December 2023
In: Frontiers in molecular neuroscience
Year: 2023, Jahrgang: 16, Pages: 1-2
ISSN:1662-5099
DOI:10.3389/fnmol.2023.1338869
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3389/fnmol.2023.1338869
Verlag, lizenzpflichtig, Volltext: https://www.frontiersin.org/articles/10.3389/fnmol.2023.1338869
Volltext
Verfasserangaben:Alexander Younsi

MARC

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520 |a Neurotrauma, encompassing traumatic brain injury (TBI), peripheral nerve injury (PNI), and spinal cord injury (SCI), continues to be a major global public health concern. The complex pathophysiological mechanisms and lifelong neurological deficits associated with neurotrauma emphasize the urgent need for effective clinical interventions. The research topic "Neurotrauma and Repair: from Peripheral to Central Nerve Injury" brought together a diverse group of 58 authors, fostering interdisciplinary collaboration, and offering new insights into the multifaceted landscape of neurotrauma research.This collaborative effort yielded a body of work that has garnered significant attention within the scientific community, underscoring the importance of the research contributions and the demand for advances in neurotrauma understanding and treatment."Effects of a Neurokinin-1 Receptor Antagonist in the Acute Phase after Thoracic Spinal Cord Injury in a Rat Model" delves into the potential therapeutic effects of neurokinin-1 receptor antagonists on neuroinflammation and edema following SCI. While the study suggests limited impact on reducing edema, it demonstrates a notable reduction in T-lymphocyte invasion and apoptotic cell numbers with the treatment. Additionally, it hints at a trend towards reduced fibrinogen leakage, endothelial and microglial activation, chondroitin sulfate glycosaminoglycan deposition, and astrogliosis. Although general locomotion recovery remained modest, the C... 
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