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Meta-analysis of epigenome-wide associations between DNA methylation at birth and childhood cognitive skills

Cognitive skills are a strong predictor of a wide range of later life outcomes. Genetic and epigenetic associations across the genome explain some of the variation in general cognitive abilities in the general population and it is plausible that epigenetic associations might arise from prenatal envi...

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Main Authors: Caramaschi, Doretta (Author) , Neumann, Alexander (Author) , Cardenas, Andres (Author) , Tindula, Gwen (Author) , Alemany, Silvia (Author) , Zillich, Lea (Author) , Pesce, Giancarlo (Author) , Lahti, Jari M. T. (Author) , Havdahl, Alexandra (Author) , Mulder, Rosa (Author) , Felix, Janine F. (Author) , Tiemeier, Henning (Author) , Sirignano, Lea (Author) , Frank, Josef (Author) , Witt, Stephanie (Author) , Rietschel, Marcella (Author) , Deuschle, Michael (Author) , Huen, Karen (Author) , Eskenazi, Brenda (Author) , Send, Tabea (Author) , Ferrer, Muriel (Author) , Gilles, Maria (Author) , de Agostini, Maria (Author) , Baïz, Nour (Author) , Rifas-Shiman, Sheryl L. (Author) , Kvist, Tuomas (Author) , Czamara, Darina (Author) , Tuominen, Samuli T. (Author) , Relton, Caroline L. (Author) , Rai, Dheeraj (Author) , London, Stephanie J. (Author) , Räikkönen, Katri (Author) , Holland, Nina (Author) , Annesi-Maesano, Isabella (Author) , Streit, Fabian (Author) , Hivert, Marie-France (Author) , Oken, Emily (Author) , Sunyer, Jordi (Author) , Cecil, Charlotte A. M. (Author) , Sharp, Gemma (Author)
Format: Article (Journal)
Language:English
Published: 10 February 2022
In: Molecular psychiatry
Year: 2022, Volume: 27, Issue: 4, Pages: 2126-2135
ISSN:1476-5578
DOI:10.1038/s41380-022-01441-w
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1038/s41380-022-01441-w
Verlag, kostenfrei, Volltext: http://www.nature.com/articles/s41380-022-01441-w
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Author Notes:Doretta Caramaschi, Alexander Neumann, Andres Cardenas, Gwen Tindula, Silvia Alemany, Lea Zillich, Giancarlo Pesce, Jari M.T. Lahti, Alexandra Havdahl, Rosa Mulder, Janine F. Felix, Henning Tiemeier, Lea Sirignano, Josef Frank, Stephanie H. Witt, Marcella Rietschel, Michael Deuschle, Karen Huen, Brenda Eskenazi, Tabea Sarah Send, Muriel Ferrer, Maria Gilles, Maria de Agostini, Nour Baïz, Sheryl L. Rifas-Shiman, Tuomas Kvist, Darina Czamara, Samuli T. Tuominen, Caroline L. Relton, Dheeraj Rai, Stephanie J. London, Katri Räikkönen, Nina Holland, Isabella Annesi-Maesano, Fabian Streit, Marie-France Hivert, Emily Oken, Jordi Sunyer, Charlotte A.M. Cecil and Gemma Sharp

MARC

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520 |a Cognitive skills are a strong predictor of a wide range of later life outcomes. Genetic and epigenetic associations across the genome explain some of the variation in general cognitive abilities in the general population and it is plausible that epigenetic associations might arise from prenatal environmental exposures and/or genetic variation early in life. We investigated the association between cord blood DNA methylation at birth and cognitive skills assessed in children from eight pregnancy cohorts within the Pregnancy And Childhood Epigenetics (PACE) Consortium across overall (total N = 2196), verbal (total N = 2206) and non-verbal cognitive scores (total N = 3300). The associations at single CpG sites were weak for all of the cognitive domains investigated. One region near DUSP22 on chromosome 6 was associated with non-verbal cognition in a model adjusted for maternal IQ. We conclude that there is little evidence to support the idea that variation in cord blood DNA methylation at single CpG sites is associated with cognitive skills and further studies are needed to confirm the association at DUSP22. 
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