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Progenitor-like cell type of an MLL-EDC4 fusion in acute myeloid leukemia: to the editor

TO THE EDITOR:Translocations involving the mixed lineage leukemia (MLL/KMT2A) gene generally confer poor prognosis in acute myeloid leukemia (AML) and display a large intertumor and intratumor heterogeneity.1 By conducting a single-cell RNA sequencing (scRNA-seq) analysis, the different developmenta...

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Hauptverfasser: Schuster, Linda (VerfasserIn) , Syed, Afzal Pasha (VerfasserIn) , Tirier, Stephan Marius (VerfasserIn) , Steiger, Simon (VerfasserIn) , Seufert, Isabelle (VerfasserIn) , Becker, Heiko (VerfasserIn) , Duque Afonso, Jesús (VerfasserIn) , Ma, Tobias (VerfasserIn) , Ogawa, Seishi (VerfasserIn) , Mallm, Jan-Philipp (VerfasserIn) , Lübbert, Michael (VerfasserIn) , Rippe, Karsten (VerfasserIn)
Dokumenttyp: Article (Journal) Editorial
Sprache:Englisch
Veröffentlicht: November 20, 2023
In: Blood advances
Year: 2023, Jahrgang: 7, Heft: 22, Pages: 7079-7083
ISSN:2473-9537
DOI:10.1182/bloodadvances.2022009096
Online-Zugang:Verlag, kostenfrei, Volltext: https://doi.org/10.1182/bloodadvances.2022009096
Verlag, kostenfrei, Volltext: https://ashpublications.org/bloodadvances/article/7/22/7079/498306/Progenitor-like-cell-type-of-an-MLL-EDC4-fusion-in
Volltext
Verfasserangaben:Linda C. Schuster, Afzal P. Syed, Stephan M. Tirier, Simon Steiger, Isabelle Seufert, Heiko Becker, Jesus Duque-Afonso, Tobias Ma, Seishi Ogawa, Jan-Philipp Mallm, Michael Lübbert, and Karsten Rippe
Beschreibung
Zusammenfassung:TO THE EDITOR:Translocations involving the mixed lineage leukemia (MLL/KMT2A) gene generally confer poor prognosis in acute myeloid leukemia (AML) and display a large intertumor and intratumor heterogeneity.1 By conducting a single-cell RNA sequencing (scRNA-seq) analysis, the different developmental stages along the hematopoietic stem cell (HSC) to myeloid trajectory can be resolved, which is relevant for self-renewal, interactions of leukemic cells with nonmalignant cells in the microenvironment, and therapy resistance.2-5 However, information on MLL-rearranged (MLL-r) cases of AML is scarce as previous scRNA-seq studies of AML by van Galen et al2 and Shlush et al3 include only 1 patient with MLL-r each. In our previous work, we have described a novel MLL fusion with the enhancer of messenger RNA decapping 4 gene (MLL-EDC4),6 for which recently another case has been reported.7
Beschreibung:Gesehen am 12.03.2024
Beschreibung:Online Resource
ISSN:2473-9537
DOI:10.1182/bloodadvances.2022009096

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