Osteopontin but not osteonectin favors the metastatic growth of pancreatic cancer cell lines
Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer- related death in Western countries and among the malignancies with the worst prognosis. Osteonectin and osteopontin, two proteins of the extracellular matrix, have been found to be up-regulated in PDAC. In the present stu...
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| Hauptverfasser: | , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2010
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| In: |
Cancer biology & therapy
Year: 2010, Jahrgang: 10, Heft: 1, Pages: 54-64 |
| ISSN: | 1555-8576 |
| DOI: | 10.4161/cbt.10.1.12161 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.4161/cbt.10.1.12161
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| Verfasserangaben: | Maria Zhivkova-Galunska, Hassan Adwan, Ergül Eyol, Jörg Kleeff, Armin Kolb, Frank Bergmann, Martin R. Berger |
MARC
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| 520 | |a Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer- related death in Western countries and among the malignancies with the worst prognosis. Osteonectin and osteopontin, two proteins of the extracellular matrix, have been found to be up-regulated in PDAC. In the present study the expression of osteopontin mRNA as determined in a panel of 14 human pancreatic cancer cell lines was significantly related to the growth these cell lines in the liver of nude rats (p=0.001) whereas osteonectin showed a trend of being negatively related to pancreatic cancer cell growth in vivo (p=0.10). In an in vitro co-culture model of human Suit2-007 and rat AsML PDAC cells with rat hepatocytes, a clearly increased expression of OPN mRNA was found in the tumor cells. In addition both, down-regulation of osteopontin with specific antisense oligonucleotides and treatment with exogenous rh-osteonectin were associated with reduced cell proliferation. In accordance with the latter finding down-regulation of osteonectin was coupled with increased proliferation. This evidence supports a protumorigenic role of osteopontin and points to an anti-tumorigenic role of osteonectin in PDAC. | ||
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