Seroprevalence of Zika in Brazil stratified by age and geographic distribution
Congenital Zika is a devastating consequence of maternal Zika virus infections. Estimates of age-dependent seroprevalence profiles are central to our understanding of the force of Zika virus infections. We set out to calculate the age-dependent seroprevalence of Zika virus infections in Brazil. We a...
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| Main Authors: | , , , , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
15 November 2023
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| In: |
Epidemiology and infection
Year: 2023, Volume: 151, Pages: 1-7 |
| ISSN: | 1469-4409 |
| DOI: | 10.1017/S0950268823001814 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1017/S0950268823001814 Verlag, lizenzpflichtig, Volltext: https://www.cambridge.org/core/journals/epidemiology-and-infection/article/seroprevalence-of-zika-in-brazil-stratified-by-age-and-geographic-distribution/02E2A7233D4FA932C3B9F7CDC7DDCE6B 
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| Author Notes: | Viviane Fongaro Botosso, Alexander Roberto Precioso, Annelies Wilder-Smith, Danielle Bruna Leal de Oliveira, Fabyano Bruno Leal de Oliveira, Cairo Monteiro De Oliveira, Camila Pereira Soares, Lucyana Trindade Leal Oliveira, Ralyria Mello Vieira dos Santo, Carla Lilian de Agostini Utescher, Francisco Antonio Bezerra Coutinho and Eduardo Massad |
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| 520 | |a Congenital Zika is a devastating consequence of maternal Zika virus infections. Estimates of age-dependent seroprevalence profiles are central to our understanding of the force of Zika virus infections. We set out to calculate the age-dependent seroprevalence of Zika virus infections in Brazil. We analyzed serum samples stratified by age and geographic location, collected from 2016 to 2019, from about 16,000 volunteers enrolled in a Phase 3 dengue vaccine trial led by the Institute Butantan in Brazil. Our results show that Zika seroprevalence has a remarkable age-dependent and geographical distribution, with an average age of the first infection varying from region to region, ranging from 4.97 (3.03-5.41) to 7.24 (6.98-7.90) years. The calculated basic reproduction number, , varied from region to region, ranging from 1.18 (1.04-1.41) to 2.33 (1.54-3.85). Such data are paramount to determine the optimal age to vaccinate against Zika, if and when such a vaccine becomes available. | ||
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