Loss of miR-192-5p initiates a hyperglycolysis and stemness positive feedback in hepatocellular carcinoma
Emerging studies revealed that cancer stem cells (CSCs) possessed peculiar metabolic properties, which however remained largely unknown in hepatocellular carcinoma (HCC). Genetic silencing of liver-abundant miR-192-5p was a key feature for multiple groups of CSC-positive HCCs. We thus aimed to inves...
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| Hauptverfasser: | , , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
30 November 2020
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| In: |
Journal of experimental & clinical cancer research
Year: 2020, Jahrgang: 39, Pages: 1-17 |
| ISSN: | 1756-9966 |
| DOI: | 10.1186/s13046-020-01785-7 |
| Online-Zugang: | Resolving-System, kostenfrei, Volltext: https://doi.org/10.1186/s13046-020-01785-7 Verlag, kostenfrei, Volltext: https://jeccr.biomedcentral.com/articles/10.1186/s13046-020-01785-7 
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| Verfasserangaben: | Yuanzhuo Gu, Fubo Ji, Niya Liu, Yongzhi Zhao, Xiyang Wei, Shiyuan Hu, Wei Jia, Xin Wei Wang, Anuradha Budhu, Juling Ji, Bin Zhao, Stephanie Roessler, Xin Zheng and Junfang Ji |
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| 520 | |a Emerging studies revealed that cancer stem cells (CSCs) possessed peculiar metabolic properties, which however remained largely unknown in hepatocellular carcinoma (HCC). Genetic silencing of liver-abundant miR-192-5p was a key feature for multiple groups of CSC-positive HCCs. We thus aimed to investigate essential metabolic features of hepatic CSCs via using HCCs with miR-192-5p silencing as a model. | ||
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