Triggering receptor expressed on myeloid cells-1 in sepsis, and current insights into clinical studies
Triggering receptor expressed on myeloid cells-1 (TREM-1) is a pattern recognition receptor and plays a critical role in the immune response. TREM-1 activation leads to the production and release of proinflammatory cytokines, chemokines, as well as its own expression and circulating levels of the cl...
Gespeichert in:
| Hauptverfasser: | , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
09 January 2024
|
| In: |
Critical care
Year: 2024, Jahrgang: 28, Heft: 1, Pages: 1-13 |
| ISSN: | 1466-609X |
| DOI: | 10.1186/s13054-024-04798-2 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/s13054-024-04798-2
|
| Verfasserangaben: | Vivienne Theobald, Felix Carl Fabian Schmitt, Chiara Simone Middel, Lena Gaissmaier, Thorsten Brenner and Markus Alexander Weigand |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1883470307 | ||
| 003 | DE-627 | ||
| 005 | 20240703153616.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240314s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1186/s13054-024-04798-2 |2 doi | |
| 035 | |a (DE-627)1883470307 | ||
| 035 | |a (DE-599)KXP1883470307 | ||
| 035 | |a (OCoLC)1443645630 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Theobald, Vivienne |d 1997- |e VerfasserIn |0 (DE-588)120823112X |0 (DE-627)1694456242 |4 aut | |
| 245 | 1 | 0 | |a Triggering receptor expressed on myeloid cells-1 in sepsis, and current insights into clinical studies |c Vivienne Theobald, Felix Carl Fabian Schmitt, Chiara Simone Middel, Lena Gaissmaier, Thorsten Brenner and Markus Alexander Weigand |
| 264 | 1 | |c 09 January 2024 | |
| 300 | |b Illustrationen | ||
| 300 | |a 13 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Published 09 January 2024 | ||
| 500 | |a Gesehen am 14.03.2024 | ||
| 520 | |a Triggering receptor expressed on myeloid cells-1 (TREM-1) is a pattern recognition receptor and plays a critical role in the immune response. TREM-1 activation leads to the production and release of proinflammatory cytokines, chemokines, as well as its own expression and circulating levels of the cleaved soluble extracellular portion of TREM-1 (sTREM-1). Because patients with sepsis and septic shock show elevated sTREM-1 levels, TREM-1 has attracted attention as an important contributor to the inadequate immune response in this often-deadly condition. Since 2001, when the first blockade of TREM-1 in sepsis was performed, many potential TREM-1 inhibitors have been established in animal models. However, only one of them, nangibotide, has entered clinical trials, which have yielded promising data for future treatment of sepsis, septic shock, and other inflammatory disease such as COVID-19. This review discusses the TREM-1 pathway and important ligands, and highlights the development of novel inhibitors as well as their clinical potential for targeted treatment of various inflammatory conditions. | ||
| 650 | 4 | |a Biomarkers | |
| 650 | 4 | |a Nangibotide | |
| 650 | 4 | |a Sepsis | |
| 650 | 4 | |a Targeted therapy | |
| 650 | 4 | |a TREM-1 | |
| 650 | 4 | |a TREM-1 inhibition | |
| 700 | 1 | |a Schmitt, Felix |d 1983- |e VerfasserIn |0 (DE-588)1038428327 |0 (DE-627)757395775 |0 (DE-576)392394375 |4 aut | |
| 700 | 1 | |a Heim, Chiara |d 1997- |e VerfasserIn |0 (DE-588)1243112697 |0 (DE-627)1773549774 |4 aut | |
| 700 | 1 | |a Gaißmaier, Lena |d 1996- |e VerfasserIn |0 (DE-588)1250460697 |0 (DE-627)1787337537 |4 aut | |
| 700 | 1 | |a Brenner, Thorsten |d 1978- |e VerfasserIn |0 (DE-588)130125709 |0 (DE-627)491713363 |0 (DE-576)189360607 |4 aut | |
| 700 | 1 | |a Weigand, Markus A. |d 1967- |e VerfasserIn |0 (DE-588)1064970435 |0 (DE-627)815375239 |0 (DE-576)424658666 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Critical care |d London : BioMed Central, 1997 |g 28(2024), 1, Artikel-ID 17, Seite 1-13 |h Online-Ressource |w (DE-627)331258269 |w (DE-600)2051256-9 |w (DE-576)279224680 |x 1466-609X |7 nnas |a Triggering receptor expressed on myeloid cells-1 in sepsis, and current insights into clinical studies |
| 773 | 1 | 8 | |g volume:28 |g year:2024 |g number:1 |g elocationid:17 |g pages:1-13 |g extent:13 |a Triggering receptor expressed on myeloid cells-1 in sepsis, and current insights into clinical studies |
| 856 | 4 | 0 | |u https://doi.org/10.1186/s13054-024-04798-2 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |7 1 |
| 951 | |a AR | ||
| 992 | |a 20240314 | ||
| 993 | |a Article | ||
| 994 | |a 2024 | ||
| 998 | |g 1064970435 |a Weigand, Markus A. |m 1064970435:Weigand, Markus A. |d 910000 |d 910300 |e 910000PW1064970435 |e 910300PW1064970435 |k 0/910000/ |k 1/910000/910300/ |p 6 |y j | ||
| 998 | |g 130125709 |a Brenner, Thorsten |m 130125709:Brenner, Thorsten |d 50000 |e 50000PB130125709 |k 0/50000/ |p 5 | ||
| 998 | |g 1250460697 |a Gaißmaier, Lena |m 1250460697:Gaißmaier, Lena |d 910000 |d 910300 |e 910000PG1250460697 |e 910300PG1250460697 |k 0/910000/ |k 1/910000/910300/ |p 4 | ||
| 998 | |g 1243112697 |a Heim, Chiara |m 1243112697:Heim, Chiara |d 910000 |d 910300 |e 910000PH1243112697 |e 910300PH1243112697 |k 0/910000/ |k 1/910000/910300/ |p 3 | ||
| 998 | |g 1038428327 |a Schmitt, Felix |m 1038428327:Schmitt, Felix |d 910000 |d 910300 |d 50000 |e 910000PS1038428327 |e 910300PS1038428327 |e 50000PS1038428327 |k 0/910000/ |k 1/910000/910300/ |k 0/50000/ |p 2 | ||
| 998 | |g 120823112X |a Theobald, Vivienne |m 120823112X:Theobald, Vivienne |d 910000 |d 910300 |e 910000PT120823112X |e 910300PT120823112X |k 0/910000/ |k 1/910000/910300/ |p 1 |x j | ||
| 999 | |a KXP-PPN1883470307 |e 4500344772 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"language":["eng"],"person":[{"given":"Vivienne","role":"aut","family":"Theobald","display":"Theobald, Vivienne"},{"display":"Schmitt, Felix","family":"Schmitt","given":"Felix","role":"aut"},{"family":"Heim","display":"Heim, Chiara","role":"aut","given":"Chiara"},{"given":"Lena","role":"aut","display":"Gaißmaier, Lena","family":"Gaißmaier"},{"role":"aut","given":"Thorsten","display":"Brenner, Thorsten","family":"Brenner"},{"role":"aut","given":"Markus A.","family":"Weigand","display":"Weigand, Markus A."}],"id":{"doi":["10.1186/s13054-024-04798-2"],"eki":["1883470307"]},"recId":"1883470307","relHost":[{"physDesc":[{"extent":"Online-Ressource"}],"recId":"331258269","id":{"eki":["331258269"],"zdb":["2051256-9"],"issn":["1466-609X"]},"title":[{"title":"Critical care","subtitle":"the leading online forum for critical care, intensive care and emergency medicine","title_sort":"Critical care"}],"pubHistory":["1.1997 -"],"origin":[{"publisherPlace":"London ; Berlin ; Heidelberg","publisher":"BioMed Central ; Springer","dateIssuedKey":"1997","dateIssuedDisp":"1997-"}],"note":["Gesehen am 01.07.2015"],"disp":"Triggering receptor expressed on myeloid cells-1 in sepsis, and current insights into clinical studiesCritical care","type":{"media":"Online-Ressource","bibl":"periodical"},"language":["eng"],"titleAlt":[{"title":"The critical care forum"}],"part":{"year":"2024","pages":"1-13","issue":"1","text":"28(2024), 1, Artikel-ID 17, Seite 1-13","extent":"13","volume":"28"}}],"name":{"displayForm":["Vivienne Theobald, Felix Carl Fabian Schmitt, Chiara Simone Middel, Lena Gaissmaier, Thorsten Brenner and Markus Alexander Weigand"]},"physDesc":[{"extent":"13 S.","noteIll":"Illustrationen"}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"note":["Published 09 January 2024","Gesehen am 14.03.2024"],"origin":[{"dateIssuedDisp":"09 January 2024","dateIssuedKey":"2024"}],"title":[{"title_sort":"Triggering receptor expressed on myeloid cells-1 in sepsis, and current insights into clinical studies","title":"Triggering receptor expressed on myeloid cells-1 in sepsis, and current insights into clinical studies"}]} | ||
| SRT | |a THEOBALDVITRIGGERING0920 | ||