Antibodies against multiple merozoite surface antigens of the human malaria parasite Plasmodium falciparum inhibit parasite maturation and red blood cell invasion
Plasmodium falciparum merozoites expose at their surface a large protein complex, which is composed of fragments of merozoite surface protein 1 (MSP-1; called MSP-183, MSP-130, MSP-138, and MSP-142) plus associated processing products of MSP-6 and MSP-7. During erythrocyte invasion this complex, as...
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| Main Authors: | , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
18 March 2010
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| In: |
Malaria journal
Year: 2010, Volume: 9, Issue: 1, Pages: 1-12 |
| ISSN: | 1475-2875 |
| DOI: | 10.1186/1475-2875-9-77 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/1475-2875-9-77
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| Author Notes: | Ute Woehlbier, Christian Epp, Fiona Hackett, Michael J. Blackman, Hermann Bujard |
| Summary: | Plasmodium falciparum merozoites expose at their surface a large protein complex, which is composed of fragments of merozoite surface protein 1 (MSP-1; called MSP-183, MSP-130, MSP-138, and MSP-142) plus associated processing products of MSP-6 and MSP-7. During erythrocyte invasion this complex, as well as an integral membrane protein called apical membrane antigen-1 (AMA-1), is shed from the parasite surface following specific proteolysis. Components of the MSP-1/6/7 complex and AMA-1 are presently under development as malaria vaccines. |
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| Item Description: | Gesehen am 15.03.2024 |
| Physical Description: | Online Resource |
| ISSN: | 1475-2875 |
| DOI: | 10.1186/1475-2875-9-77 |