Buchumschlag

Stereotactic body radiation therapy versus surgical resection for stage I/II hepatocellular carcinoma

SBRT is an emerging locoregional treatment modality for hepatocellular carcinoma (HCC). Although local tumor control rates seem encouraging, large-scale survival data comparing SBRT to surgical resection are lacking. We identified patients with stage I/II HCC from the National Cancer Database amenab...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Birgin, Emrullah (VerfasserIn) , Hetjens, Svetlana (VerfasserIn) , Tam, Moses (VerfasserIn) , Correa-Gallego, Camilo (VerfasserIn) , Rahbari, Nuh Nabi (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 17 April 2023
In: Cancers
Year: 2023, Jahrgang: 15, Heft: 8, Pages: 1-14
ISSN:2072-6694
DOI:10.3390/cancers15082330
Online-Zugang:Verlag, kostenfrei, Volltext: https://doi.org/10.3390/cancers15082330
Verlag, kostenfrei, Volltext: https://www.mdpi.com/2072-6694/15/8/2330
Volltext
Verfasserangaben:Emrullah Birgin, Svetlana Hetjens, Moses Tam, Camilo Correa-Gallego and Nuh N. Rahbari

MARC

LEADER 00000caa a2200000 c 4500
001 1883748054
003 DE-627
005 20240703154543.0
007 cr uuu---uuuuu
008 240319s2023 xx |||||o 00| ||eng c
024 7 |a 10.3390/cancers15082330  |2 doi 
035 |a (DE-627)1883748054 
035 |a (DE-599)KXP1883748054 
035 |a (OCoLC)1443657235 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 33  |2 sdnb 
100 1 |a Birgin, Emrullah  |d 1988-  |e VerfasserIn  |0 (DE-588)1140789880  |0 (DE-627)898681960  |0 (DE-576)494041625  |4 aut 
245 1 0 |a Stereotactic body radiation therapy versus surgical resection for stage I/II hepatocellular carcinoma  |c Emrullah Birgin, Svetlana Hetjens, Moses Tam, Camilo Correa-Gallego and Nuh N. Rahbari 
264 1 |c 17 April 2023 
300 |b Illustrationen 
300 |a 14 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Gesehen am 19.03.2024 
520 |a SBRT is an emerging locoregional treatment modality for hepatocellular carcinoma (HCC). Although local tumor control rates seem encouraging, large-scale survival data comparing SBRT to surgical resection are lacking. We identified patients with stage I/II HCC from the National Cancer Database amenable for potential surgical resection. Patients undergoing hepatectomy were matched by propensity score (1:2) with patients who underwent SBRT as primary treatment. A total of 3787 (91%) and 366 (9%) patients underwent surgical resection or SBRT between 2004 and 2015, respectively. After propensity matching, the 5-year overall survival was 24% (95% CI 19-30%) in the SBRT group versus 48% (95% CI 43-53%) in the surgery group (p < 0.001). The association of surgery with overall survival was consistent in all subgroups. In patients treated with SBRT, a biologic effective dose (BED) of ≥100 Gy (31%, 95% CI 22%-40%) compared with BED < 100 Gy (13%, 95% CI 8-22%) was associated with a higher 5-year overall survival rate (hazard ratio of mortality of 0.58, 95% CI 0.43-0.77; p < 0.001). Surgical resection may be associated with prolonged overall survival compared with SBRT in patients with stage I/II HCC. 
650 4 |a ablative 4 
650 4 |a HCC 5 
650 4 |a liver resection 2 
650 4 |a multimodal 3 
650 4 |a SBRT 1 
700 1 |a Hetjens, Svetlana  |d 1983-  |e VerfasserIn  |0 (DE-588)1031801979  |0 (DE-627)737600284  |0 (DE-576)379534223  |4 aut 
700 1 |a Tam, Moses  |e VerfasserIn  |4 aut 
700 1 |a Correa-Gallego, Camilo  |e VerfasserIn  |4 aut 
700 1 |a Rahbari, Nuh Nabi  |d 1980-  |e VerfasserIn  |0 (DE-588)132519356  |0 (DE-627)523331908  |0 (DE-576)299198464  |4 aut 
773 0 8 |i Enthalten in  |t Cancers  |d Basel : MDPI, 2009  |g 15(2023), 8, Seite 1-14  |h Online-Ressource  |w (DE-627)614095670  |w (DE-600)2527080-1  |w (DE-576)313958548  |x 2072-6694  |7 nnas  |a Stereotactic body radiation therapy versus surgical resection for stage I/II hepatocellular carcinoma 
773 1 8 |g volume:15  |g year:2023  |g number:8  |g pages:1-14  |g extent:14  |a Stereotactic body radiation therapy versus surgical resection for stage I/II hepatocellular carcinoma 
856 4 0 |u https://doi.org/10.3390/cancers15082330  |x Verlag  |x Resolving-System  |z kostenfrei  |3 Volltext 
856 4 0 |u https://www.mdpi.com/2072-6694/15/8/2330  |x Verlag  |z kostenfrei  |3 Volltext 
951 |a AR 
992 |a 20240319 
993 |a Article 
994 |a 2023 
998 |g 132519356  |a Rahbari, Nuh Nabi  |m 132519356:Rahbari, Nuh Nabi  |d 60000  |d 61800  |e 60000PR132519356  |e 61800PR132519356  |k 0/60000/  |k 1/60000/61800/  |p 5  |y j 
998 |g 1031801979  |a Hetjens, Svetlana  |m 1031801979:Hetjens, Svetlana  |d 60000  |d 60200  |d 60250  |e 60000PH1031801979  |e 60200PH1031801979  |e 60250PH1031801979  |k 0/60000/  |k 1/60000/60200/  |k 2/60000/60200/60250/  |p 2 
998 |g 1140789880  |a Birgin, Emrullah  |m 1140789880:Birgin, Emrullah  |d 60000  |d 61800  |e 60000PB1140789880  |e 61800PB1140789880  |k 0/60000/  |k 1/60000/61800/  |p 1  |x j 
999 |a KXP-PPN1883748054  |e 4501544643 
BIB |a Y 
SER |a journal 
JSO |a {"language":["eng"],"title":[{"title":"Stereotactic body radiation therapy versus surgical resection for stage I/II hepatocellular carcinoma","title_sort":"Stereotactic body radiation therapy versus surgical resection for stage I/II hepatocellular carcinoma"}],"physDesc":[{"extent":"14 S.","noteIll":"Illustrationen"}],"name":{"displayForm":["Emrullah Birgin, Svetlana Hetjens, Moses Tam, Camilo Correa-Gallego and Nuh N. Rahbari"]},"note":["Gesehen am 19.03.2024"],"type":{"media":"Online-Ressource","bibl":"article-journal"},"person":[{"given":"Emrullah","family":"Birgin","display":"Birgin, Emrullah","role":"aut"},{"role":"aut","display":"Hetjens, Svetlana","family":"Hetjens","given":"Svetlana"},{"family":"Tam","display":"Tam, Moses","role":"aut","given":"Moses"},{"given":"Camilo","family":"Correa-Gallego","display":"Correa-Gallego, Camilo","role":"aut"},{"display":"Rahbari, Nuh Nabi","family":"Rahbari","role":"aut","given":"Nuh Nabi"}],"relHost":[{"id":{"issn":["2072-6694"],"eki":["614095670"],"zdb":["2527080-1"]},"origin":[{"publisher":"MDPI","publisherPlace":"Basel","dateIssuedKey":"2009","dateIssuedDisp":"2009-"}],"title":[{"title":"Cancers","title_sort":"Cancers"}],"physDesc":[{"extent":"Online-Ressource"}],"language":["eng"],"name":{"displayForm":["Molecular Diversity Preservation International (MDPI)"]},"note":["Gesehen am 27.05.2020"],"recId":"614095670","type":{"bibl":"periodical","media":"Online-Ressource"},"pubHistory":["1.2009 -"],"disp":"Stereotactic body radiation therapy versus surgical resection for stage I/II hepatocellular carcinomaCancers","part":{"pages":"1-14","volume":"15","text":"15(2023), 8, Seite 1-14","year":"2023","extent":"14","issue":"8"}}],"recId":"1883748054","id":{"eki":["1883748054"],"doi":["10.3390/cancers15082330"]},"origin":[{"dateIssuedDisp":"17 April 2023","dateIssuedKey":"2023"}]} 
SRT |a BIRGINEMRUSTEREOTACT1720 

Ähnliche Einträge