Alpha-1-antitrypsin-deficiency is associated with lower cardiovascular risk: an approach based on federated learning
Chronic obstructive pulmonary disease (COPD) is an inflammatory multisystemic disease caused by environmental exposures and/or genetic factors. Inherited alpha-1-antitrypsin deficiency (AATD) is one of the best recognized genetic factors increasing the risk for an early onset COPD with emphysema. Th...
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| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
18 January 2024
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| In: |
Respiratory research
Year: 2024, Volume: 25, Issue: 1, Pages: 1-10 |
| ISSN: | 1465-993X |
| DOI: | 10.1186/s12931-023-02607-y |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s12931-023-02607-y Verlag, kostenfrei, Volltext: https://respiratory-research.biomedcentral.com/articles/10.1186/s12931-023-02607-y 
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| Author Notes: | Daniela Zöller, Christian Haverkamp, Adeline Makoudjou, Ghislain Sofack, Saskia Kiefer, Denis Gebele, Michelle Pfaffenlehner, Martin Boeker, Harald Binder, Kapil Karki, Christian Seidemann, Bernd Schmeck, Timm Greulich, Harald Renz, Stefanie Schild, Susanne A. Seuchter, Dativa Tibyampansha, Roland Buhl, Gernot Rohde, Franziska C. Trudzinski, Robert Bals, Sabina Janciauskiene, Daiana Stolz and Sebastian Fähndrich |
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| 520 | |a Chronic obstructive pulmonary disease (COPD) is an inflammatory multisystemic disease caused by environmental exposures and/or genetic factors. Inherited alpha-1-antitrypsin deficiency (AATD) is one of the best recognized genetic factors increasing the risk for an early onset COPD with emphysema. The aim of this study was to gain a better understanding of the associations between comorbidities and specific biomarkers in COPD patients with and without AATD to enable future investigations aimed, for example, at identifying risk factors or improving care. | ||
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