Ein neues Antikoagulans zur Probengewinnung für Thrombozytenfunktionstests = A new anticoagulant for blood sampling tubes for platelet function tests
Background: The difficult pre-analytical conditions of platelet function diagnostics discourage its widespread use, e.g., to detect resistance to acetylsalicylic acid (ASA) and/or clopidogrel. Platelet activation during blood drawing and sample preparation cannot be prevented by citrate anticoagulat...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | German |
| Published: |
7. Mai 2010
|
| In: |
Laboratoriumsmedizin
Year: 2010, Volume: 34, Issue: 3, Pages: 149-153 |
| ISSN: | 1439-0477 |
| DOI: | 10.1515/jlm.2010.026 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1515/jlm.2010.026 Verlag, lizenzpflichtig, Volltext: https://www.degruyterbrill.com/document/doi/10.1515/jlm.2010.026/html 
|
| Author Notes: | Johanna Wolf, Martin Sigl, Evangelos Giannitsis und Boris Ivandic |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1884036414 | ||
| 003 | DE-627 | ||
| 005 | 20250530003455.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240321s2010 xx |||||o 00| ||ger c | ||
| 024 | 7 | |a 10.1515/jlm.2010.026 |2 doi | |
| 035 | |a (DE-627)1884036414 | ||
| 035 | |a (DE-599)KXP1884036414 | ||
| 035 | |a (OCoLC)1443657225 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a ger | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Wolf, Johanna |e VerfasserIn |0 (DE-588)1111514577 |0 (DE-627)865584605 |0 (DE-576)476000270 |4 aut | |
| 245 | 1 | 4 | |a Ein neues Antikoagulans zur Probengewinnung für Thrombozytenfunktionstests |b = A new anticoagulant for blood sampling tubes for platelet function tests |c Johanna Wolf, Martin Sigl, Evangelos Giannitsis und Boris Ivandic |
| 246 | 3 | 1 | |a A new anticoagulant for blood sampling tubes for platelet function tests |
| 264 | 1 | |c 7. Mai 2010 | |
| 300 | |b Illustrationen | ||
| 300 | |a 5 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 21.03.2024 | ||
| 520 | |a Background: The difficult pre-analytical conditions of platelet function diagnostics discourage its widespread use, e.g., to detect resistance to acetylsalicylic acid (ASA) and/or clopidogrel. Platelet activation during blood drawing and sample preparation cannot be prevented by citrate anticoagulation. Here, we tested a new blood sampling tube containing the anticoagulant benzylsulfonyl-D-argininyl-prolyl-4-amidinobenzylamide (Thrombovette ® , Probe & go, Osburg, Germany). Methods: A total of 46 emergency patients taking ASA and clopidogrel as well as 20 healthy volunteers were included in the study. Blood was drawn into Thrombovette ® and citrate S-Monovette ® tubes (Sarstedt AG&Co, Nümbrecht, Germany) and transported to the lab via the pneumatic tube system. Whole blood impedance aggregometry (model 560Ca, Chrono-Log, Havertown, PA, USA) was performed using collagen and ADP as platelet agonist (final concentrations 1 mg/L and 5 μM, respectively). Results: Reference ranges and cut-off values for the determination of drug resistance were obtained from the healthy cohort. Positive predictive values were 94.6% and 94.1% for inhibition of aggregation by ASA, and 68.0% and 53.3% for inhibition by clopidogrel using Thrombovette ® and citrate S-Monovette ® , respectively. Negative predictive values were 82.8% and 75.0% for ASA resistance and 87.8% and 83.3% for clopidogrel resistance using Thrombovette ® and citrate S-Monovette ® , respectively. Conclusions: Thrombovette ® is a promising new system for blood sampling and could improve the validity of platelet function diagnostics. | ||
| 546 | |a Artikel deutsch, mit englischer Zusammenfassung | ||
| 650 | 4 | |a anticoagulant | |
| 650 | 4 | |a Antikoagulans | |
| 650 | 4 | |a aspirin | |
| 650 | 4 | |a Aspirin | |
| 650 | 4 | |a clopidogrel | |
| 650 | 4 | |a Clopidogrel | |
| 650 | 4 | |a platelets | |
| 650 | 4 | |a Thrombozyten | |
| 700 | 1 | |a Sigl, Martin |d 1979- |e VerfasserIn |0 (DE-588)136454828 |0 (DE-627)58329782X |0 (DE-576)301029172 |4 aut | |
| 700 | 1 | |a Giannitsis, Evangelos |e VerfasserIn |0 (DE-588)113336241 |0 (DE-627)577184091 |0 (DE-576)289759579 |4 aut | |
| 700 | 1 | |a Ivandic, Boris |e VerfasserIn |0 (DE-588)1031172165 |0 (DE-627)735782245 |0 (DE-576)378581821 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Laboratoriumsmedizin |d Berlin [u.a.] : de Gruyter, 1977 |g 34(2010), 3, Seite 149-153 |h Online-Ressource |w (DE-627)349877254 |w (DE-600)2081704-6 |w (DE-576)09960499X |x 1439-0477 |7 nnas |a Ein neues Antikoagulans zur Probengewinnung für Thrombozytenfunktionstests = A new anticoagulant for blood sampling tubes for platelet function tests |
| 773 | 1 | 8 | |g volume:34 |g year:2010 |g number:3 |g pages:149-153 |g extent:5 |a Ein neues Antikoagulans zur Probengewinnung für Thrombozytenfunktionstests = A new anticoagulant for blood sampling tubes for platelet function tests |
| 856 | 4 | 0 | |u https://doi.org/10.1515/jlm.2010.026 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.degruyterbrill.com/document/doi/10.1515/jlm.2010.026/html |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20240321 | ||
| 993 | |a Article | ||
| 994 | |a 2010 | ||
| 998 | |g 1031172165 |a Ivandic, Boris |m 1031172165:Ivandic, Boris |d 910000 |d 910100 |e 910000PI1031172165 |e 910100PI1031172165 |k 0/910000/ |k 1/910000/910100/ |p 4 |y j | ||
| 998 | |g 113336241 |a Giannitsis, Evangelos |m 113336241:Giannitsis, Evangelos |d 910000 |d 910100 |e 910000PG113336241 |e 910100PG113336241 |k 0/910000/ |k 1/910000/910100/ |p 3 | ||
| 998 | |g 136454828 |a Sigl, Martin |m 136454828:Sigl, Martin |d 910000 |d 910100 |e 910000PS136454828 |e 910100PS136454828 |k 0/910000/ |k 1/910000/910100/ |p 2 | ||
| 998 | |g 1111514577 |a Wolf, Johanna |m 1111514577:Wolf, Johanna |d 910000 |d 910100 |e 910000PW1111514577 |e 910100PW1111514577 |k 0/910000/ |k 1/910000/910100/ |p 1 |x j | ||
| 999 | |a KXP-PPN1884036414 |e 4502888141 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"name":{"displayForm":["Johanna Wolf, Martin Sigl, Evangelos Giannitsis und Boris Ivandic"]},"id":{"eki":["1884036414"],"doi":["10.1515/jlm.2010.026"]},"origin":[{"dateIssuedKey":"2010","dateIssuedDisp":" 7. Mai 2010"}],"person":[{"display":"Wolf, Johanna","given":"Johanna","role":"aut","family":"Wolf"},{"family":"Sigl","role":"aut","given":"Martin","display":"Sigl, Martin"},{"role":"aut","given":"Evangelos","family":"Giannitsis","display":"Giannitsis, Evangelos"},{"family":"Ivandic","role":"aut","given":"Boris","display":"Ivandic, Boris"}],"relHost":[{"part":{"pages":"149-153","text":"34(2010), 3, Seite 149-153","extent":"5","issue":"3","year":"2010","volume":"34"},"id":{"eki":["349877254"],"issn":["1439-0477"],"zdb":["2081704-6"],"doi":["10.1111/(ISSN)1439-0477"]},"pubHistory":["1.1977 - 41.2017"],"titleAlt":[{"title":"Diagnostische Bibliothek"},{"title":"Ausbildung und Beruf"},{"title":"Wissenschaft und Fortbildung"},{"title":"Laboratoriums Medizin"}],"type":{"bibl":"periodical","media":"Online-Ressource"},"language":["ger","eng"],"title":[{"title":"Laboratoriumsmedizin","title_sort":"Laboratoriumsmedizin","subtitle":" = Journal of laboratory medicine"}],"origin":[{"dateIssuedKey":"1977","publisherPlace":"Berlin [u.a.] ; Berlin","dateIssuedDisp":"1977-2017","publisher":"de Gruyter ; Blackwell-Wiss.-Verl."}],"titleTranslated":[{"translated":"Journal of laboratory medicine"}],"disp":"Ein neues Antikoagulans zur Probengewinnung für Thrombozytenfunktionstests = A new anticoagulant for blood sampling tubes for platelet function testsLaboratoriumsmedizin","physDesc":[{"extent":"Online-Ressource"}],"recId":"349877254"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"language":["ger"],"note":["Gesehen am 21.03.2024"],"title":[{"title":"Ein neues Antikoagulans zur Probengewinnung für Thrombozytenfunktionstests","title_sort":"neues Antikoagulans zur Probengewinnung für Thrombozytenfunktionstests","subtitle":" = A new anticoagulant for blood sampling tubes for platelet function tests"}],"physDesc":[{"noteIll":"Illustrationen","extent":"5 S."}],"recId":"1884036414","titleTranslated":[{"translated":"A new anticoagulant for blood sampling tubes for platelet function tests"}]} | ||
| SRT | |a WOLFJOHANNNEUESANTIK7201 | ||