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Childhood exposure to hunger: associations with health outcomes in later life and epigenetic markers

Aim: To assess associations of early exposure to hunger with depressive symptoms and cardiovascular disease (CVD) and to investigate possible epigenetic pathways. Patients & methods: Data were based on a German population-based cohort of older adults (n = 9631). Regression models were performed...

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Hauptverfasser: Perna, Laura (VerfasserIn) , Zhang, Yan (VerfasserIn) , Wild, Beate (VerfasserIn) , Kliegel, Matthias (VerfasserIn) , Ihle, Andreas (VerfasserIn) , Schöttker, Ben (VerfasserIn) , Mons, Ute (VerfasserIn) , Brenner, Hermann (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 20 Nov 2020
In: Epigenomics
Year: 2020, Jahrgang: 12, Heft: 21, Pages: 1861-1870
ISSN:1750-192X
DOI:10.2217/epi-2019-0333
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.2217/epi-2019-0333
Verlag, lizenzpflichtig, Volltext: https://www.futuremedicine.com/doi/10.2217/epi-2019-0333
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Verfasserangaben:Laura Perna, Yan Zhang, Beate Wild, Matthias Kliegel, Andreas Ihle, Ben Schöttker, Ute Mons, Hermann Brenner
Beschreibung
Zusammenfassung:Aim: To assess associations of early exposure to hunger with depressive symptoms and cardiovascular disease (CVD) and to investigate possible epigenetic pathways. Patients & methods: Data were based on a German population-based cohort of older adults (n = 9631). Regression models were performed for health outcomes in later life. An epigenome-wide association study for early-life exposure to hunger was performed in a subgroup (n = 2221) with whole blood DNA methylation data. Results: Childhood exposure to hunger was associated with CVD and depressive symptoms in later life. Prenatal or infant exposure was strongly associated with depressive symptoms. No CpG reached epigenome-wide significance after multiple testing correction. Conclusion: Childhood hunger is a risk factor for depressive symptoms and CVD at older age. DNA methylation could not explain this association.
Beschreibung:Gesehen am 22.03.2024
Beschreibung:Online Resource
ISSN:1750-192X
DOI:10.2217/epi-2019-0333

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