Childhood exposure to hunger: associations with health outcomes in later life and epigenetic markers
Aim: To assess associations of early exposure to hunger with depressive symptoms and cardiovascular disease (CVD) and to investigate possible epigenetic pathways. Patients & methods: Data were based on a German population-based cohort of older adults (n = 9631). Regression models were performed...
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| Main Authors: | , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
20 Nov 2020
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| In: |
Epigenomics
Year: 2020, Volume: 12, Issue: 21, Pages: 1861-1870 |
| ISSN: | 1750-192X |
| DOI: | 10.2217/epi-2019-0333 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.2217/epi-2019-0333 Verlag, lizenzpflichtig, Volltext: https://www.futuremedicine.com/doi/10.2217/epi-2019-0333 
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| Author Notes: | Laura Perna, Yan Zhang, Beate Wild, Matthias Kliegel, Andreas Ihle, Ben Schöttker, Ute Mons, Hermann Brenner |
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| 520 | |a Aim: To assess associations of early exposure to hunger with depressive symptoms and cardiovascular disease (CVD) and to investigate possible epigenetic pathways. Patients & methods: Data were based on a German population-based cohort of older adults (n = 9631). Regression models were performed for health outcomes in later life. An epigenome-wide association study for early-life exposure to hunger was performed in a subgroup (n = 2221) with whole blood DNA methylation data. Results: Childhood exposure to hunger was associated with CVD and depressive symptoms in later life. Prenatal or infant exposure was strongly associated with depressive symptoms. No CpG reached epigenome-wide significance after multiple testing correction. Conclusion: Childhood hunger is a risk factor for depressive symptoms and CVD at older age. DNA methylation could not explain this association. | ||
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