Baseline modified Glasgow Prognostic Score (mGPS) predicts radiologic response and overall survival in metastatic hormone-sensitive prostate cancer treated with docetaxel chemotherapy
Background/Aim: To assess the baseline inflammatory markers modified Glasgow Prognostic Score (mGPS), systemic immune-inflammation index (SII), and neutrophile-to-lymphocyte ratio (NLR) as pragmatic tools for predicting response to chemohormonal therapy (docetaxel plus ADT) and prognosis in men with...
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| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
April 2022
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| In: |
Anticancer research
Year: 2022, Jahrgang: 42, Heft: 4, Pages: 1911-1918 |
| ISSN: | 1791-7530 |
| DOI: | 10.21873/anticanres.15668 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.21873/anticanres.15668 Verlag, lizenzpflichtig, Volltext: https://ar.iiarjournals.org/content/42/4/1911 
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| Verfasserangaben: | Manuel Neuberger, Janina Skladny, Nora Goly, Frederik Wessels, Christel Weiß, Luisa Egen, Philipp Erben, Matthias Groß-Weege, Britta Grüne, Friedrich Hartung, Jonas Herrmann, Patrick Honeck, Jonas Jarczyk, Karl-Friedrich Kowalewski, Julia Mühlbauer, Katja Nitschke, Malin Nientiedt, Margarete Theresa Walach, Frank Waldbillig, Niklas Westhoff, Jost von Hardenberg, Maximilian Kriegmair, Thomas S. Worst and Philipp Nuhn |
MARC
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| 245 | 1 | 0 | |a Baseline modified Glasgow Prognostic Score (mGPS) predicts radiologic response and overall survival in metastatic hormone-sensitive prostate cancer treated with docetaxel chemotherapy |c Manuel Neuberger, Janina Skladny, Nora Goly, Frederik Wessels, Christel Weiß, Luisa Egen, Philipp Erben, Matthias Groß-Weege, Britta Grüne, Friedrich Hartung, Jonas Herrmann, Patrick Honeck, Jonas Jarczyk, Karl-Friedrich Kowalewski, Julia Mühlbauer, Katja Nitschke, Malin Nientiedt, Margarete Theresa Walach, Frank Waldbillig, Niklas Westhoff, Jost von Hardenberg, Maximilian Kriegmair, Thomas S. Worst and Philipp Nuhn |
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| 500 | |a Margarete Teresa Walach ist fälschlich als Margarete Theresa Walach geschrieben | ||
| 500 | |a Gesehen am 25.03.2024 | ||
| 520 | |a Background/Aim: To assess the baseline inflammatory markers modified Glasgow Prognostic Score (mGPS), systemic immune-inflammation index (SII), and neutrophile-to-lymphocyte ratio (NLR) as pragmatic tools for predicting response to chemohormonal therapy (docetaxel plus ADT) and prognosis in men with metastatic hormone-sensitive prostate cancer (mHSPC). Patients and Methods: Male patients who received docetaxel at a tertiary university care center between 2014 and 2019 were screened for completion of 6 cycles. NLR, SII, mGPS, overall survival (OS), three-year survival, and radiologic response were assessed. Complete response (CR), partial response (PR), and stable disease (SD) were analyzed alone and in combination. Results: Thirty-six mHSPC-patients were included. In thirty patients, baseline mGPS was assessed and was either 0 (n=22) or 2 (n=8). In Cochran-Armitage Trend Test, mGPS showed significant association with the combined radiologic endpoint of “CR, PR, or SD” (p=0.01), three-year survival (p=0.02), and OS (p<0.01). Next to prostate-specific antigen (PSA) (HR per 100 units 1.16, 95%CI=1.04-1.30, p<0.01), NLR (HR=1.31, 95%CI=1.03-1.66, p=0.03), and mGPS (2 vs. 0, HR=6.53, 95%CI=1.6-27.0, p<0.01) at baseline showed significant association with OS in univariable cox regression. However, mGPS remained the only independent predictor for OS in multivariable cox regression (p<0.01) and for the combined radiologic endpoint of “CR, PR or SD” (p=0.01) in multivariable logistic regression. SII showed no statistical relevance. Conclusion: Baseline mGPS seems to be a pragmatic tool for clinical decision-making in patients with mHSPC in daily routine. | ||
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| 650 | 4 | |a neutrophile-to-lymphocyte ratio | |
| 650 | 4 | |a overall survival | |
| 650 | 4 | |a prognosis | |
| 650 | 4 | |a systemic immune-inflammation index | |
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