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Baseline modified Glasgow Prognostic Score (mGPS) predicts radiologic response and overall survival in metastatic hormone-sensitive prostate cancer treated with docetaxel chemotherapy

Background/Aim: To assess the baseline inflammatory markers modified Glasgow Prognostic Score (mGPS), systemic immune-inflammation index (SII), and neutrophile-to-lymphocyte ratio (NLR) as pragmatic tools for predicting response to chemohormonal therapy (docetaxel plus ADT) and prognosis in men with...

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Hauptverfasser: Neuberger, Manuel (VerfasserIn) , Skladny, Janina (VerfasserIn) , Goly, Nora (VerfasserIn) , Wessels, Frederik (VerfasserIn) , Weiß, Christel (VerfasserIn) , Egen, Luisa (VerfasserIn) , Erben, Philipp (VerfasserIn) , Groß-Weege, Matthias (VerfasserIn) , Grüne, Britta (VerfasserIn) , Hartung, Friedrich (VerfasserIn) , Herrmann, Jonas (VerfasserIn) , Honeck, Patrick (VerfasserIn) , Jarczyk, Jonas (VerfasserIn) , Kowalewski, Karl-Friedrich (VerfasserIn) , Mühlbauer, Julia (VerfasserIn) , Nitschke, Katja (VerfasserIn) , Nientiedt, Malin (VerfasserIn) , Walach, Margarete (VerfasserIn) , Waldbillig, Frank (VerfasserIn) , Westhoff, Niklas Christian (VerfasserIn) , Hardenberg, Jost von (VerfasserIn) , Kriegmair, Maximilian (VerfasserIn) , Worst, Thomas (VerfasserIn) , Nuhn, Philipp (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: April 2022
In: Anticancer research
Year: 2022, Jahrgang: 42, Heft: 4, Pages: 1911-1918
ISSN:1791-7530
DOI:10.21873/anticanres.15668
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.21873/anticanres.15668
Verlag, lizenzpflichtig, Volltext: https://ar.iiarjournals.org/content/42/4/1911
Volltext
Verfasserangaben:Manuel Neuberger, Janina Skladny, Nora Goly, Frederik Wessels, Christel Weiß, Luisa Egen, Philipp Erben, Matthias Groß-Weege, Britta Grüne, Friedrich Hartung, Jonas Herrmann, Patrick Honeck, Jonas Jarczyk, Karl-Friedrich Kowalewski, Julia Mühlbauer, Katja Nitschke, Malin Nientiedt, Margarete Theresa Walach, Frank Waldbillig, Niklas Westhoff, Jost von Hardenberg, Maximilian Kriegmair, Thomas S. Worst and Philipp Nuhn
Beschreibung
Zusammenfassung:Background/Aim: To assess the baseline inflammatory markers modified Glasgow Prognostic Score (mGPS), systemic immune-inflammation index (SII), and neutrophile-to-lymphocyte ratio (NLR) as pragmatic tools for predicting response to chemohormonal therapy (docetaxel plus ADT) and prognosis in men with metastatic hormone-sensitive prostate cancer (mHSPC). Patients and Methods: Male patients who received docetaxel at a tertiary university care center between 2014 and 2019 were screened for completion of 6 cycles. NLR, SII, mGPS, overall survival (OS), three-year survival, and radiologic response were assessed. Complete response (CR), partial response (PR), and stable disease (SD) were analyzed alone and in combination. Results: Thirty-six mHSPC-patients were included. In thirty patients, baseline mGPS was assessed and was either 0 (n=22) or 2 (n=8). In Cochran-Armitage Trend Test, mGPS showed significant association with the combined radiologic endpoint of “CR, PR, or SD” (p=0.01), three-year survival (p=0.02), and OS (p<0.01). Next to prostate-specific antigen (PSA) (HR per 100 units 1.16, 95%CI=1.04-1.30, p<0.01), NLR (HR=1.31, 95%CI=1.03-1.66, p=0.03), and mGPS (2 vs. 0, HR=6.53, 95%CI=1.6-27.0, p<0.01) at baseline showed significant association with OS in univariable cox regression. However, mGPS remained the only independent predictor for OS in multivariable cox regression (p<0.01) and for the combined radiologic endpoint of “CR, PR or SD” (p=0.01) in multivariable logistic regression. SII showed no statistical relevance. Conclusion: Baseline mGPS seems to be a pragmatic tool for clinical decision-making in patients with mHSPC in daily routine.
Beschreibung:Online veröffentlicht: 28. März 2022
Margarete Teresa Walach ist fälschlich als Margarete Theresa Walach geschrieben
Gesehen am 25.03.2024
Beschreibung:Online Resource
ISSN:1791-7530
DOI:10.21873/anticanres.15668

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