Borderline personality disorder and the big five: molecular genetic analyses indicate shared genetic architecture with neuroticism and openness
Both environmental (e.g. interpersonal traumatization during childhood and adolescence) and genetic factors may contribute to the development of Borderline Personality Disorder (BPD). Twin studies assessing borderline personality symptoms/features in the general population indicate that genetic fact...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
11 April 2022
|
| In: |
Translational Psychiatry
Year: 2022, Jahrgang: 12, Pages: 1-8 |
| ISSN: | 2158-3188 |
| DOI: | 10.1038/s41398-022-01912-2 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1038/s41398-022-01912-2 Verlag, kostenfrei, Volltext: http://www.nature.com/articles/s41398-022-01912-2 
|
| Verfasserangaben: | Fabian Streit, Stephanie H. Witt, Swapnil Awasthi, Jerome C. Foo, Martin Jungkunz, Josef Frank, Lucía Colodro-Conde, Guy Hindley, Olav B. Smeland, Tolou Maslahati, Cornelia E. Schwarze, Norbert Dahmen, Björn H. Schott, Nikolaus Kleindienst, Annette Hartmann, Ina Giegling, Lea Zillich, Lea Sirignano, Eric Poisel, Chi-Hua Chen, Markus M. Nöthen, Arian Mobascher, Dan Rujescu, Klaus Lieb, Stefan Roepke, Christian Schmahl, Martin Bohus, Stephan Ripke, Marcella Rietschel and Ole A. Andreassen |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1884321437 | ||
| 003 | DE-627 | ||
| 005 | 20250116012128.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240326s2022 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1038/s41398-022-01912-2 |2 doi | |
| 035 | |a (DE-627)1884321437 | ||
| 035 | |a (DE-599)KXP1884321437 | ||
| 035 | |a (OCoLC)1443657973 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Streit, Fabian |d 1982- |e VerfasserIn |0 (DE-588)113749199X |0 (DE-627)894689843 |0 (DE-576)491387970 |4 aut | |
| 245 | 1 | 0 | |a Borderline personality disorder and the big five: molecular genetic analyses indicate shared genetic architecture with neuroticism and openness |c Fabian Streit, Stephanie H. Witt, Swapnil Awasthi, Jerome C. Foo, Martin Jungkunz, Josef Frank, Lucía Colodro-Conde, Guy Hindley, Olav B. Smeland, Tolou Maslahati, Cornelia E. Schwarze, Norbert Dahmen, Björn H. Schott, Nikolaus Kleindienst, Annette Hartmann, Ina Giegling, Lea Zillich, Lea Sirignano, Eric Poisel, Chi-Hua Chen, Markus M. Nöthen, Arian Mobascher, Dan Rujescu, Klaus Lieb, Stefan Roepke, Christian Schmahl, Martin Bohus, Stephan Ripke, Marcella Rietschel and Ole A. Andreassen |
| 264 | 1 | |c 11 April 2022 | |
| 300 | |a 8 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 26.03.2024 | ||
| 520 | |a Both environmental (e.g. interpersonal traumatization during childhood and adolescence) and genetic factors may contribute to the development of Borderline Personality Disorder (BPD). Twin studies assessing borderline personality symptoms/features in the general population indicate that genetic factors underlying these symptoms/features are shared in part with the personality traits of the Five Factor Model (FFM) of personality—the “Big Five”. In the present study, the genetic overlap of BPD with the Big Five -Openness to Experience, Conscientiousness, Extraversion, Agreeableness, and Neuroticism- was assessed. Linkage disequilibrium score regression was used to calculate genetic correlations between a genome-wide association study (GWAS) in central European populations on BPD (N = 2543) and GWAS on the Big Five (N = 76,551-122,886, Neuroticism N = 390,278). Polygenic scores (PGS) were calculated to test the association of the genetic disposition for the personality traits with BPD case-control status. Significant positive genetic correlations of BPD were found with Neuroticism (rg = 0.34, p = 6.3*10−5) and Openness (rg = 0.24, p = 0.036), but not with the other personality traits (all | rg | <0.14, all p > 0.30). A cluster and item-level analysis showed positive genetic correlations of BPD with the Neuroticism clusters “Depressed Affect” and “Worry”, and with a broad range of Neuroticism items (N = 348,219-376,352). PGS analyses confirmed the genetic correlations, and found an independent contribution of the personality traits to BPD risk. The observed associations indicate a partially shared genetic background of BPD and the personality traits Neuroticism and Openness. Larger GWAS of BPD and the “Big Five” are needed to further explore the role of personality traits in the etiology of BPD. | ||
| 650 | 4 | |a Clinical genetics | |
| 650 | 4 | |a Psychiatric disorders | |
| 700 | 1 | |a Witt, Stephanie |d 1970- |e VerfasserIn |0 (DE-588)132177897 |0 (DE-627)519022432 |0 (DE-576)298988399 |4 aut | |
| 700 | 1 | |a Awasthi, Swapnil |e VerfasserIn |4 aut | |
| 700 | 1 | |a Foo, Jerome Clifford |d 1983- |e VerfasserIn |0 (DE-588)1162226293 |0 (DE-627)1025697510 |0 (DE-576)507278933 |4 aut | |
| 700 | 1 | |a Jungkunz, Martin |e VerfasserIn |0 (DE-588)1171828322 |0 (DE-627)1040719155 |0 (DE-576)513863230 |4 aut | |
| 700 | 1 | |a Frank, Josef |d 1972- |e VerfasserIn |0 (DE-588)1138799653 |0 (DE-627)896382850 |0 (DE-576)492700249 |4 aut | |
| 700 | 1 | |8 1\p |a Colodro-Conde, Lucía |e VerfasserIn |0 (DE-588)1187529745 |0 (DE-627)1666547441 |4 aut | |
| 700 | 1 | |a Hindley, Guy |e VerfasserIn |4 aut | |
| 700 | 1 | |a Smeland, Olav B. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Maslahati, Tolou |e VerfasserIn |4 aut | |
| 700 | 1 | |a Schwarze, Cornelia E. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Dahmen, Norbert |e VerfasserIn |4 aut | |
| 700 | 1 | |a Schott, Björn H. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kleindienst, Nikolaus |d 1965- |e VerfasserIn |0 (DE-588)129283622 |0 (DE-627)392389053 |0 (DE-576)297578340 |4 aut | |
| 700 | 1 | |a Hartmann, Annette |e VerfasserIn |4 aut | |
| 700 | 1 | |a Giegling, Ina |e VerfasserIn |4 aut | |
| 700 | 1 | |a Zillich, Lea |d 1994- |e VerfasserIn |0 (DE-588)1133523404 |0 (DE-627)889399670 |0 (DE-576)489474969 |4 aut | |
| 700 | 1 | |a Sirignano, Lea |d 1992- |e VerfasserIn |0 (DE-588)1220871281 |0 (DE-627)1737997118 |4 aut | |
| 700 | 1 | |a Zillich, Eric |d 1999- |e VerfasserIn |0 (DE-588)1195550960 |0 (DE-627)1677570016 |4 aut | |
| 700 | 1 | |a Chen, Chi-Hua |e VerfasserIn |4 aut | |
| 700 | 1 | |8 2\p |a Nöthen, Markus Maria |e VerfasserIn |0 (DE-588)1069221139 |0 (DE-627)821594591 |0 (DE-576)428541534 |4 aut | |
| 700 | 1 | |a Mobascher, Arian |e VerfasserIn |4 aut | |
| 700 | 1 | |8 3\p |a Rujescu, Dan |e VerfasserIn |0 (DE-588)110316516X |0 (DE-627)860809110 |0 (DE-576)470516747 |4 aut | |
| 700 | 1 | |a Lieb, Klaus |e VerfasserIn |4 aut | |
| 700 | 1 | |a Roepke, Stefan |e VerfasserIn |4 aut | |
| 700 | 1 | |a Schmahl, Christian |d 1968- |e VerfasserIn |0 (DE-588)1028601611 |0 (DE-627)731311906 |0 (DE-576)376093927 |4 aut | |
| 700 | 1 | |a Bohus, Martin |d 1956- |e VerfasserIn |0 (DE-588)123588308 |0 (DE-627)082645469 |0 (DE-576)167043471 |4 aut | |
| 700 | 1 | |a Ripke, Stephan |e VerfasserIn |4 aut | |
| 700 | 1 | |a Rietschel, Marcella |d 1957- |e VerfasserIn |0 (DE-588)112785751 |0 (DE-627)505574020 |0 (DE-576)289742307 |4 aut | |
| 700 | 1 | |8 4\p |a Andreassen, Ole A. |e VerfasserIn |0 (DE-588)1261097432 |0 (DE-627)1830480146 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Translational Psychiatry |d London : Nature Publishing Group, 2011 |g 12(2022), Artikel-ID 153, Seite 1-8 |h Online-Ressource |w (DE-627)660807378 |w (DE-600)2609311-X |w (DE-576)345003462 |x 2158-3188 |7 nnas |a Borderline personality disorder and the big five: molecular genetic analyses indicate shared genetic architecture with neuroticism and openness |
| 773 | 1 | 8 | |g volume:12 |g year:2022 |g elocationid:153 |g pages:1-8 |g extent:8 |a Borderline personality disorder and the big five: molecular genetic analyses indicate shared genetic architecture with neuroticism and openness |
| 856 | 4 | 0 | |u https://doi.org/10.1038/s41398-022-01912-2 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u http://www.nature.com/articles/s41398-022-01912-2 |x Verlag |z kostenfrei |3 Volltext |
| 883 | |8 1\p |a cgwrk |d 20241001 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 883 | |8 2\p |a cgwrk |d 20241001 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 883 | |8 3\p |a cgwrk |d 20241001 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 883 | |8 4\p |a cgwrk |d 20241001 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 951 | |a AR | ||
| 992 | |a 20240326 | ||
| 993 | |a Article | ||
| 994 | |a 2022 | ||
| 998 | |g 112785751 |a Rietschel, Marcella |m 112785751:Rietschel, Marcella |d 60000 |e 60000PR112785751 |k 0/60000/ |p 29 | ||
| 998 | |g 123588308 |a Bohus, Martin |m 123588308:Bohus, Martin |d 60000 |e 60000PB123588308 |k 0/60000/ |p 27 | ||
| 998 | |g 1028601611 |a Schmahl, Christian |m 1028601611:Schmahl, Christian |d 60000 |e 60000PS1028601611 |k 0/60000/ |p 26 | ||
| 998 | |g 1195550960 |a Zillich, Eric |m 1195550960:Zillich, Eric |d 60000 |e 60000PZ1195550960 |k 0/60000/ |p 19 | ||
| 998 | |g 1220871281 |a Sirignano, Lea |m 1220871281:Sirignano, Lea |d 60000 |e 60000PS1220871281 |k 0/60000/ |p 18 | ||
| 998 | |g 1133523404 |a Zillich, Lea |m 1133523404:Zillich, Lea |d 60000 |e 60000PZ1133523404 |k 0/60000/ |p 17 | ||
| 998 | |g 129283622 |a Kleindienst, Nikolaus |m 129283622:Kleindienst, Nikolaus |d 60000 |e 60000PK129283622 |k 0/60000/ |p 14 | ||
| 998 | |g 1138799653 |a Frank, Josef |m 1138799653:Frank, Josef |d 60000 |e 60000PF1138799653 |k 0/60000/ |p 6 | ||
| 998 | |g 1171828322 |a Jungkunz, Martin |m 1171828322:Jungkunz, Martin |p 5 | ||
| 998 | |g 1162226293 |a Foo, Jerome Clifford |m 1162226293:Foo, Jerome Clifford |d 60000 |e 60000PF1162226293 |k 0/60000/ |p 4 | ||
| 998 | |g 132177897 |a Witt, Stephanie |m 132177897:Witt, Stephanie |d 60000 |e 60000PW132177897 |k 0/60000/ |p 2 | ||
| 998 | |g 113749199X |a Streit, Fabian |m 113749199X:Streit, Fabian |d 60000 |e 60000PS113749199X |k 0/60000/ |p 1 |x j | ||
| 999 | |a KXP-PPN1884321437 |e 4503881892 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"note":["Gesehen am 26.03.2024"],"title":[{"title_sort":"Borderline personality disorder and the big five: molecular genetic analyses indicate shared genetic architecture with neuroticism and openness","title":"Borderline personality disorder and the big five: molecular genetic analyses indicate shared genetic architecture with neuroticism and openness"}],"relHost":[{"title":[{"title":"Translational Psychiatry","title_sort":"Translational Psychiatry"}],"note":["Gesehen am 17.05.11"],"disp":"Borderline personality disorder and the big five: molecular genetic analyses indicate shared genetic architecture with neuroticism and opennessTranslational Psychiatry","language":["eng"],"physDesc":[{"extent":"Online-Ressource"}],"id":{"eki":["660807378"],"issn":["2158-3188"],"zdb":["2609311-X"]},"type":{"bibl":"periodical","media":"Online-Ressource"},"recId":"660807378","part":{"text":"12(2022), Artikel-ID 153, Seite 1-8","volume":"12","pages":"1-8","year":"2022","extent":"8"},"origin":[{"publisherPlace":"London","dateIssuedDisp":"2011-","publisher":"Nature Publishing Group","dateIssuedKey":"2011"}],"pubHistory":["1.2011 -"]}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"person":[{"display":"Streit, Fabian","family":"Streit","given":"Fabian","roleDisplay":"VerfasserIn","role":"aut"},{"given":"Stephanie","role":"aut","roleDisplay":"VerfasserIn","display":"Witt, Stephanie","family":"Witt"},{"display":"Awasthi, Swapnil","family":"Awasthi","given":"Swapnil","roleDisplay":"VerfasserIn","role":"aut"},{"display":"Foo, Jerome Clifford","family":"Foo","given":"Jerome Clifford","roleDisplay":"VerfasserIn","role":"aut"},{"roleDisplay":"VerfasserIn","role":"aut","given":"Martin","family":"Jungkunz","display":"Jungkunz, Martin"},{"given":"Josef","role":"aut","roleDisplay":"VerfasserIn","display":"Frank, Josef","family":"Frank"},{"display":"Colodro-Conde, Lucía","family":"Colodro-Conde","given":"Lucía","role":"aut","roleDisplay":"VerfasserIn"},{"display":"Hindley, Guy","family":"Hindley","given":"Guy","roleDisplay":"VerfasserIn","role":"aut"},{"family":"Smeland","display":"Smeland, Olav B.","role":"aut","roleDisplay":"VerfasserIn","given":"Olav B."},{"family":"Maslahati","display":"Maslahati, Tolou","role":"aut","roleDisplay":"VerfasserIn","given":"Tolou"},{"role":"aut","roleDisplay":"VerfasserIn","given":"Cornelia E.","family":"Schwarze","display":"Schwarze, Cornelia E."},{"given":"Norbert","role":"aut","roleDisplay":"VerfasserIn","display":"Dahmen, Norbert","family":"Dahmen"},{"display":"Schott, Björn H.","family":"Schott","given":"Björn H.","roleDisplay":"VerfasserIn","role":"aut"},{"display":"Kleindienst, Nikolaus","family":"Kleindienst","given":"Nikolaus","role":"aut","roleDisplay":"VerfasserIn"},{"roleDisplay":"VerfasserIn","role":"aut","given":"Annette","family":"Hartmann","display":"Hartmann, Annette"},{"given":"Ina","roleDisplay":"VerfasserIn","role":"aut","display":"Giegling, Ina","family":"Giegling"},{"family":"Zillich","display":"Zillich, Lea","roleDisplay":"VerfasserIn","role":"aut","given":"Lea"},{"display":"Sirignano, Lea","family":"Sirignano","given":"Lea","role":"aut","roleDisplay":"VerfasserIn"},{"family":"Zillich","display":"Zillich, Eric","role":"aut","roleDisplay":"VerfasserIn","given":"Eric"},{"role":"aut","roleDisplay":"VerfasserIn","given":"Chi-Hua","family":"Chen","display":"Chen, Chi-Hua"},{"family":"Nöthen","display":"Nöthen, Markus Maria","role":"aut","roleDisplay":"VerfasserIn","given":"Markus Maria"},{"display":"Mobascher, Arian","family":"Mobascher","given":"Arian","role":"aut","roleDisplay":"VerfasserIn"},{"family":"Rujescu","display":"Rujescu, Dan","roleDisplay":"VerfasserIn","role":"aut","given":"Dan"},{"role":"aut","roleDisplay":"VerfasserIn","given":"Klaus","family":"Lieb","display":"Lieb, Klaus"},{"given":"Stefan","role":"aut","roleDisplay":"VerfasserIn","display":"Roepke, Stefan","family":"Roepke"},{"given":"Christian","roleDisplay":"VerfasserIn","role":"aut","display":"Schmahl, Christian","family":"Schmahl"},{"family":"Bohus","display":"Bohus, Martin","roleDisplay":"VerfasserIn","role":"aut","given":"Martin"},{"display":"Ripke, Stephan","family":"Ripke","given":"Stephan","role":"aut","roleDisplay":"VerfasserIn"},{"given":"Marcella","role":"aut","roleDisplay":"VerfasserIn","display":"Rietschel, Marcella","family":"Rietschel"},{"given":"Ole A.","role":"aut","roleDisplay":"VerfasserIn","display":"Andreassen, Ole A.","family":"Andreassen"}],"origin":[{"dateIssuedKey":"2022","dateIssuedDisp":"11 April 2022"}],"recId":"1884321437","name":{"displayForm":["Fabian Streit, Stephanie H. Witt, Swapnil Awasthi, Jerome C. Foo, Martin Jungkunz, Josef Frank, Lucía Colodro-Conde, Guy Hindley, Olav B. Smeland, Tolou Maslahati, Cornelia E. Schwarze, Norbert Dahmen, Björn H. Schott, Nikolaus Kleindienst, Annette Hartmann, Ina Giegling, Lea Zillich, Lea Sirignano, Eric Poisel, Chi-Hua Chen, Markus M. Nöthen, Arian Mobascher, Dan Rujescu, Klaus Lieb, Stefan Roepke, Christian Schmahl, Martin Bohus, Stephan Ripke, Marcella Rietschel and Ole A. Andreassen"]},"physDesc":[{"extent":"8 S."}],"id":{"doi":["10.1038/s41398-022-01912-2"],"eki":["1884321437"]},"language":["eng"]} | ||
| SRT | |a STREITFABIBORDERLINE1120 | ||