A nationwide trend analysis on the usage of endomyocardial biopsy
Background Endomyocardial biopsy (EMB) is a safe procedure performed in diagnostic work-up of cardiac disease.Hypothesis Data regarding temporal trends of total numbers, characteristics, in-hospital outcomes, and complications of patients undergoing EMB are sparse.Methods The nationwide German inpat...
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| Main Authors: | , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
Feb 2024
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| In: |
Clinical cardiology
Year: 2024, Volume: 47, Issue: 2, Pages: 1-13 |
| ISSN: | 1932-8737 |
| DOI: | 10.1002/clc.24198 |
| Online Access: | Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1002/clc.24198 Verlag, lizenzpflichtig, Volltext: https://www.webofscience.com/api/gateway?GWVersion=2&SrcAuth=DynamicDOIArticle&SrcApp=WOS&KeyAID=10.1002%2Fclc.24198&DestApp=DOI&SrcAppSID=EUW1ED0F2FBOs7T1amMwlJFS8dCLW&SrcJTitle=CLINICAL+CARDIOLOGY&DestDOIRegistrantName=Wiley+%28John+Wiley+%26+Sons%29 
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| Author Notes: | Karsten Keller MD, FESC, Sebastian Goebel MD, Tommaso Gori MD, Thomas Muenzel MD, Philip Wenzel MD, Lukas Hobohm MD |
| Summary: | Background Endomyocardial biopsy (EMB) is a safe procedure performed in diagnostic work-up of cardiac disease.Hypothesis Data regarding temporal trends of total numbers, characteristics, in-hospital outcomes, and complications of patients undergoing EMB are sparse.Methods The nationwide German inpatient sample (2005-2019) was used for this analysis. Patient cases of EBM during the 5-year cycles from 2005 to 2009, 2010 to 2014, and 2015 to 2019 were compared, and temporal trends regarding total numbers and presumable major and minor EMB-associated complications were investigated.Results Overall, 67 745 EMB were performed in Germany 2005-2019. Total number of EMB increased from 3083 in 2005 to 5646 in 2019 (beta 0.40 [95% confidence interval [CI] 0.37-0.43], p < .001). Among these EMB, 19 083 (28.2%) were performed during the period 2005-2009, 22 867 (33.7%) 2010-2014, and 25 795 (38.1%) between 2015 and 2019. The proportion of patients aged >= 70 years was highest 2015-2019 (2005-2009: 9.3%; 2010-2014: 13.8%; 2015-2019: 16.1%, p < .001) and the most aggravated comorbidity profile (Charlson Comorbidity Index 2.25 +/- 1.93; 2.67 +/- 2.14; 3.01 +/- 2.29, p < .001) was also detected 2015-2019. Major complications occurred less often in the period 2015-2019 compared to 2005-2009 (odds ratio [OR] 0.921 [95% CI 0.893-0.950], p < .001), whereas minor complications were more frequently observed between 2015 and 2019 (OR 1.067 [95% CI 1.042-1.093], p < .001). While a decrease in major complications was detected irrespective of age, an increase in minor complications was identified only in patients between 30-59 years.Conclusions Annual numbers of EMB increased significantly in Germany 2005-2019. Patients who underwent EMB in recent years were older and showed an aggravated comorbidity profile accompanied by fewer major complications, underscoring safety of the procedure. |
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| Item Description: | Gesehen am 09.04.2024 |
| Physical Description: | Online Resource |
| ISSN: | 1932-8737 |
| DOI: | 10.1002/clc.24198 |