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Graft-versus-host disease is locally maintained in target tissues by resident progenitor-like T cells

In allogeneic hematopoietic stem cell transplantation, donor αβ T cells attack recipient tissues, causing graft-versus-host disease (GVHD), a major cause of morbidity and mortality. A central question has been how GVHD is sustained despite T cell exhaustion from chronic antigen stimulation. The curr...

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Hauptverfasser: Sacirbegovic, Faruk (VerfasserIn) , Günther, Matthias (VerfasserIn) , Greco, Alessandro (VerfasserIn) , Zhao, Daqiang (VerfasserIn) , Wang, Xi (VerfasserIn) , Zhou, Meng (VerfasserIn) , Rosenberger, Sarah (VerfasserIn) , Oberbarnscheidt, Martin H. (VerfasserIn) , Held, Werner (VerfasserIn) , McNiff, Jennifer (VerfasserIn) , Jain, Dhanpat (VerfasserIn) , Höfer, Thomas (VerfasserIn) , Shlomchik, Warren D. (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 14 February 2023
In: Immunity
Year: 2023, Jahrgang: 56, Heft: 2, Pages: 369-385, e1-e6
ISSN:1097-4180
DOI:10.1016/j.immuni.2023.01.003
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.immuni.2023.01.003
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S1074761323000134
Volltext
Verfasserangaben:Faruk Sacirbegovic, Matthias Günther, Alessandro Greco, Daqiang Zhao, Xi Wang, Meng Zhou, Sarah Rosenberger, Martin H. Oberbarnscheidt, Werner Held, Jennifer McNiff, Dhanpat Jain, Thomas Höfer, and Warren D. Shlomchik
Beschreibung
Zusammenfassung:In allogeneic hematopoietic stem cell transplantation, donor αβ T cells attack recipient tissues, causing graft-versus-host disease (GVHD), a major cause of morbidity and mortality. A central question has been how GVHD is sustained despite T cell exhaustion from chronic antigen stimulation. The current model for GVHD holds that disease is maintained through the continued recruitment of alloreactive effectors from blood into affected tissues. Here, we show, using multiple approaches including parabiosis of mice with GVHD, that GVHD is instead primarily maintained locally within diseased tissues. By tracking 1,203 alloreactive T cell clones, we fitted a mathematical model predicting that within each tissue a small number of progenitor T cells maintain a larger effector pool. Consistent with this, we identified a tissue-resident TCF-1+ subpopulation that preferentially engrafted, expanded, and differentiated into effectors upon adoptive transfer. These results suggest that therapies targeting affected tissues and progenitor T cells within them would be effective.
Beschreibung:Online verfügbar 30 January 2023, Version des Artikels 14 February 2023
Gesehen am 10.04.2024
Beschreibung:Online Resource
ISSN:1097-4180
DOI:10.1016/j.immuni.2023.01.003

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