The neurophysiological effect of mild hypothermia in gyrencephalic brains submitted to ischemic stroke and spreading depolarizations
Objective: Characterize the neurophysiological effects of mild hypothermia on stroke and spreading depolarizations (SDs) in gyrencephalic brains. Methods: Left middle cerebral arteries (MCAs) of six hypothermic and six normothermic pigs were permanently occluded (MCAo). Hypothermia began 1 h after M...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
14 March 2024
|
| In: |
Frontiers in neuroscience
Year: 2024, Jahrgang: 18, Pages: 1-15 |
| ISSN: | 1662-453X |
| DOI: | 10.3389/fnins.2024.1302767 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.3389/fnins.2024.1302767 Verlag, kostenfrei, Volltext: https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2024.1302767/full 
|
| Verfasserangaben: | Roberto Díaz-Peregrino, Modar Kentar, Carlos Trenado, Renán Sánchez-Porras, Pablo Albiña-Palmarola, Francisco L. Ramírez-Cuapio, Daniel San-Juan, Andreas Unterberg, Johannes Woitzik and Edgar Santos |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1886518440 | ||
| 003 | DE-627 | ||
| 005 | 20240703170505.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240422s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.3389/fnins.2024.1302767 |2 doi | |
| 035 | |a (DE-627)1886518440 | ||
| 035 | |a (DE-599)KXP1886518440 | ||
| 035 | |a (OCoLC)1443669409 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Díaz-Peregrino, Roberto |d 1991- |e VerfasserIn |0 (DE-588)1312180196 |0 (DE-627)1871926564 |4 aut | |
| 245 | 1 | 4 | |a The neurophysiological effect of mild hypothermia in gyrencephalic brains submitted to ischemic stroke and spreading depolarizations |c Roberto Díaz-Peregrino, Modar Kentar, Carlos Trenado, Renán Sánchez-Porras, Pablo Albiña-Palmarola, Francisco L. Ramírez-Cuapio, Daniel San-Juan, Andreas Unterberg, Johannes Woitzik and Edgar Santos |
| 264 | 1 | |c 14 March 2024 | |
| 300 | |a 15 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 24.04.2024 | ||
| 520 | |a Objective: Characterize the neurophysiological effects of mild hypothermia on stroke and spreading depolarizations (SDs) in gyrencephalic brains. Methods: Left middle cerebral arteries (MCAs) of six hypothermic and six normothermic pigs were permanently occluded (MCAo). Hypothermia began 1 h after MCAo and continued throughout the experiment. ECoG signals from both frontoparietal cortices were recorded. Five-minute ECoG epochs were collected 5 min before, at 5 min, 4, 8, 12, and 16 h after MCAo, and before, during, and after SDs. Power spectra were decomposed into fast (alpha, beta, and gamma) and slow (delta and theta) frequency bands. Results: In the vascular insulted hemisphere under normothermia, electrodes near the ischemic core exhibited power decay across all frequency bands at 5 min and the 4th hour after MCAo. The same pattern was registered in the two furthest electrodes at the 12th and 16th hour. When mild hypothermia was applied in the vascular insulted hemispheres, the power decay was generalized and seen even in electrodes with uncompromised blood flow. During SD analysis, hypothermia maintained increased delta and beta power during the three phases of SDs in the furthest electrode from the ischemic core, followed by the second furthest and third electrode in the beta band during preSD and postSD segments. However, in hypothermic conditions, the third electrode showed lower delta, theta, and alpha power. Conclusion: Mild hypothermia attenuates all frequency bands in the vascularly compromised hemisphere, irrespective of the cortical location. During SD formation, it preserves power spectra more significantly in electrodes further from the ischemic core. | ||
| 650 | 4 | |a ECoG recording | |
| 650 | 4 | |a Mild hypothermia | |
| 650 | 4 | |a power spectrum of frequency bands | |
| 650 | 4 | |a Spreading depolarization | |
| 650 | 4 | |a Stroke progression | |
| 700 | 1 | |a Kentar, Modar |d 1980- |e VerfasserIn |0 (DE-588)1035482487 |0 (DE-627)749543620 |0 (DE-576)383068827 |4 aut | |
| 700 | 1 | |a Trenado Colin, Carlos Alberto |d 1973- |e VerfasserIn |0 (DE-588)14246015X |0 (DE-627)704233304 |0 (DE-576)328376302 |4 aut | |
| 700 | 1 | |a Sánchez-Porras, Renán |d 1980- |e VerfasserIn |0 (DE-588)1074851641 |0 (DE-627)832589683 |0 (DE-576)443004064 |4 aut | |
| 700 | 1 | |a Albiña-Palmarola, Pablo |e VerfasserIn |4 aut | |
| 700 | 1 | |a Ramírez-Cuapio, Francisco L. |d 1992- |e VerfasserIn |0 (DE-588)1221544748 |0 (DE-627)1738757080 |4 aut | |
| 700 | 1 | |a San Juan Orta, Daniel |e VerfasserIn |0 (DE-588)1165167794 |0 (DE-627)102932896X |0 (DE-576)510279031 |4 aut | |
| 700 | 1 | |a Unterberg, Andreas |e VerfasserIn |0 (DE-588)1032681187 |0 (DE-627)738641200 |0 (DE-576)168441233 |4 aut | |
| 700 | 1 | |a Woitzik, Johannes |d 1971- |e VerfasserIn |0 (DE-588)124754155 |0 (DE-627)365721573 |0 (DE-576)294483306 |4 aut | |
| 700 | 1 | |a Santos, Edgar |d 1982- |e VerfasserIn |0 (DE-588)1048580407 |0 (DE-627)780674537 |0 (DE-576)402410882 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Frontiers in neuroscience |d Lausanne : Frontiers Research Foundation, 2007 |g 18(2024), Artikel-ID 1302767, Seite 1-15 |h Online-Ressource |w (DE-627)55908109X |w (DE-600)2411902-7 |w (DE-576)281378959 |x 1662-453X |7 nnas |a The neurophysiological effect of mild hypothermia in gyrencephalic brains submitted to ischemic stroke and spreading depolarizations |
| 773 | 1 | 8 | |g volume:18 |g year:2024 |g elocationid:1302767 |g pages:1-15 |g extent:15 |a The neurophysiological effect of mild hypothermia in gyrencephalic brains submitted to ischemic stroke and spreading depolarizations |
| 856 | 4 | 0 | |u https://doi.org/10.3389/fnins.2024.1302767 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2024.1302767/full |x Verlag |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20240422 | ||
| 993 | |a Article | ||
| 994 | |a 2024 | ||
| 998 | |g 1048580407 |a Santos, Edgar |m 1048580407:Santos, Edgar |d 50000 |e 50000PS1048580407 |k 0/50000/ |p 8 | ||
| 998 | |g 1032681187 |a Unterberg, Andreas |m 1032681187:Unterberg, Andreas |d 910000 |d 911200 |e 910000PU1032681187 |e 911200PU1032681187 |k 0/910000/ |k 1/910000/911200/ |p 7 | ||
| 998 | |g 1221544748 |a Ramírez-Cuapio, Francisco L. |m 1221544748:Ramírez-Cuapio, Francisco L. |d 50000 |e 50000PR1221544748 |k 0/50000/ |p 6 | ||
| 998 | |g 1035482487 |a Kentar, Modar |m 1035482487:Kentar, Modar |d 910000 |d 911200 |e 910000PK1035482487 |e 911200PK1035482487 |k 0/910000/ |k 1/910000/911200/ |p 2 | ||
| 998 | |g 1312180196 |a Díaz-Peregrino, Roberto |m 1312180196:Díaz-Peregrino, Roberto |p 1 |x j | ||
| 999 | |a KXP-PPN1886518440 |e 4514370886 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"title":[{"title_sort":"neurophysiological effect of mild hypothermia in gyrencephalic brains submitted to ischemic stroke and spreading depolarizations","title":"The neurophysiological effect of mild hypothermia in gyrencephalic brains submitted to ischemic stroke and spreading depolarizations"}],"relHost":[{"name":{"displayForm":["Frontiers Research Foundation"]},"disp":"The neurophysiological effect of mild hypothermia in gyrencephalic brains submitted to ischemic stroke and spreading depolarizationsFrontiers in neuroscience","note":["Gesehen am 04.06.20"],"language":["eng"],"physDesc":[{"extent":"Online-Ressource"}],"title":[{"title":"Frontiers in neuroscience","title_sort":"Frontiers in neuroscience"}],"recId":"55908109X","origin":[{"publisherPlace":"Lausanne","dateIssuedKey":"2007","publisher":"Frontiers Research Foundation","dateIssuedDisp":"2007-"}],"id":{"eki":["55908109X"],"issn":["1662-453X"],"zdb":["2411902-7"]},"type":{"media":"Online-Ressource","bibl":"periodical"},"part":{"volume":"18","year":"2024","extent":"15","pages":"1-15","text":"18(2024), Artikel-ID 1302767, Seite 1-15"},"pubHistory":["1.2007 -"]}],"physDesc":[{"extent":"15 S."}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"id":{"eki":["1886518440"],"doi":["10.3389/fnins.2024.1302767"]},"language":["eng"],"person":[{"role":"aut","display":"Díaz-Peregrino, Roberto","given":"Roberto","family":"Díaz-Peregrino"},{"display":"Kentar, Modar","role":"aut","family":"Kentar","given":"Modar"},{"given":"Carlos Alberto","family":"Trenado Colin","role":"aut","display":"Trenado Colin, Carlos Alberto"},{"display":"Sánchez-Porras, Renán","role":"aut","family":"Sánchez-Porras","given":"Renán"},{"given":"Pablo","family":"Albiña-Palmarola","role":"aut","display":"Albiña-Palmarola, Pablo"},{"family":"Ramírez-Cuapio","given":"Francisco L.","display":"Ramírez-Cuapio, Francisco L.","role":"aut"},{"display":"San Juan Orta, Daniel","role":"aut","family":"San Juan Orta","given":"Daniel"},{"given":"Andreas","family":"Unterberg","role":"aut","display":"Unterberg, Andreas"},{"family":"Woitzik","given":"Johannes","display":"Woitzik, Johannes","role":"aut"},{"display":"Santos, Edgar","role":"aut","family":"Santos","given":"Edgar"}],"origin":[{"dateIssuedDisp":"14 March 2024","dateIssuedKey":"2024"}],"note":["Gesehen am 24.04.2024"],"name":{"displayForm":["Roberto Díaz-Peregrino, Modar Kentar, Carlos Trenado, Renán Sánchez-Porras, Pablo Albiña-Palmarola, Francisco L. Ramírez-Cuapio, Daniel San-Juan, Andreas Unterberg, Johannes Woitzik and Edgar Santos"]},"recId":"1886518440"} | ||
| SRT | |a DIAZPEREGRNEUROPHYSI1420 | ||