Cover Image

Genomic organization of the ATM gene

The ATM gene was recently identified and found to be responsible for the human genetic disorder ataxia-telangiectasia. The major ATM transcript is 13 kb. Using long-distance PCR, we determined the genomic structure of this gene and identified all of its exon-intron boundaries. The ATM gene spans app...

Full description

Saved in:
Bibliographic Details
Main Authors: Uziel, Tamar (Author) , Savitsky, Kinneret (Author) , Platzer, Matthias (Author) , Ziv, Yael (Author) , Helbitz, Tal (Author) , Nehls, Michael (Author) , Boehm, Thomas (Author) , Rosenthal, Andre (Author) , Shiloh, Yosef (Author) , Rotman, Galit (Author)
Format: Article (Journal)
Language:English
Published: 15 April 1996
In: Genomics
Year: 1996, Volume: 33, Issue: 2, Pages: 317-320
ISSN:1089-8646
DOI:10.1006/geno.1996.0201
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1006/geno.1996.0201
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0888754396902013
Get full text
Author Notes:Tamar Uziel, Kinneret Savitsky, Matthias Platzer, Yael Ziv, Tal Helbitz, Michael Nehls, Thomas Boehm, Andre Rosenthal, Yosef Shiloh, Galit Rotman
Description
Summary:The ATM gene was recently identified and found to be responsible for the human genetic disorder ataxia-telangiectasia. The major ATM transcript is 13 kb. Using long-distance PCR, we determined the genomic structure of this gene and identified all of its exon-intron boundaries. The ATM gene spans approximately 150 kb of genomic DNA and consists of 66 exons. The initiation codon falls within exon 4. The last exon is 3.8 kb and contains the stop codon and a 3′-untranslated region of about 3600 nucleotides.
Item Description:Gesehen am 23.04.2024
Elektronische Reproduktion der Druck-Ausgabe 25. Mai 2002
Physical Description:Online Resource
ISSN:1089-8646
DOI:10.1006/geno.1996.0201

Similar Items