Genomic organization of the ATM gene
The ATM gene was recently identified and found to be responsible for the human genetic disorder ataxia-telangiectasia. The major ATM transcript is 13 kb. Using long-distance PCR, we determined the genomic structure of this gene and identified all of its exon-intron boundaries. The ATM gene spans app...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
15 April 1996
|
| In: |
Genomics
Year: 1996, Jahrgang: 33, Heft: 2, Pages: 317-320 |
| ISSN: | 1089-8646 |
| DOI: | 10.1006/geno.1996.0201 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1006/geno.1996.0201 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0888754396902013 
|
| Verfasserangaben: | Tamar Uziel, Kinneret Savitsky, Matthias Platzer, Yael Ziv, Tal Helbitz, Michael Nehls, Thomas Boehm, Andre Rosenthal, Yosef Shiloh, Galit Rotman |
| Zusammenfassung: | The ATM gene was recently identified and found to be responsible for the human genetic disorder ataxia-telangiectasia. The major ATM transcript is 13 kb. Using long-distance PCR, we determined the genomic structure of this gene and identified all of its exon-intron boundaries. The ATM gene spans approximately 150 kb of genomic DNA and consists of 66 exons. The initiation codon falls within exon 4. The last exon is 3.8 kb and contains the stop codon and a 3′-untranslated region of about 3600 nucleotides. |
|---|---|
| Beschreibung: | Gesehen am 23.04.2024 Elektronische Reproduktion der Druck-Ausgabe 25. Mai 2002 |
| Beschreibung: | Online Resource |
| ISSN: | 1089-8646 |
| DOI: | 10.1006/geno.1996.0201 |