Expression of peptides encoded by exons in cloned mammalian DNA
New synthetic approaches, such as combinatorial chemistry, provide a rich source of potential drug candidates. At the same time, the human genome initiative and other large-scale sequencing projects provide a large number of novel drug targets. However, the functional analysis of thousands of new ge...
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| Main Authors: | , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
01 November 1996
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| In: |
Nucleic acids research
Year: 1996, Volume: 24, Issue: 21, Pages: 4358-4359 |
| ISSN: | 1362-4962 |
| DOI: | 10.1093/nar/24.21.4358 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1093/nar/24.21.4358
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| Author Notes: | Sabine Kreissig, Kerstin Schüddekopf, Neil Dear, Thomas BoehM |
MARC
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| 520 | |a New synthetic approaches, such as combinatorial chemistry, provide a rich source of potential drug candidates. At the same time, the human genome initiative and other large-scale sequencing projects provide a large number of novel drug targets. However, the functional analysis of thousands of new genes remains a major challenge for the future. A systematic strategy for genome-wide functional analysis of genes could employ the fact that at least some modules in multi-domain proteins are encoded in individual exons. Exon amplification provides information about coding regions of most genes that is independent of their transcriptional status; exon amplification from entire mammalian genomes has been demonstrated. Here, we describe the development of an exon-trap system, λGEE (for genomic exon expression), that couples exon amplification with the expression of exon-encoded peptides. | ||
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