Contrast-enhanced ultrasound (CEUS) for the evaluation of Bosniak III complex renal cystic lesions: a 10-year specialized European single-center experience with histopathological validation
Background and objectives: The aim of the present retrospective single-center study is to evaluate the diagnostic performance of contrast-enhanced ultrasound (CEUS) for assessing Bosniak III complex renal cystic lesions with histopathological validation. Materials and Methods: 49 patients with CEUS-...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
12 December 2020
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| In: |
Medicina
Year: 2020, Volume: 56, Issue: 12, Pages: 1-16 |
| ISSN: | 1648-9144 |
| DOI: | 10.3390/medicina56120692 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.3390/medicina56120692 Verlag, kostenfrei, Volltext: https://www.mdpi.com/1648-9144/56/12/692 
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| Author Notes: | Vincent Schwarze, Johannes Rübenthaler, Saša Čečatka, Constantin Marschner, Matthias Frank Froelich, Bastian Oliver Sabel, Michael Staehler, Thomas Knösel, Thomas Geyer and Dirk-André Clevert |
MARC
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| 520 | |a Background and objectives: The aim of the present retrospective single-center study is to evaluate the diagnostic performance of contrast-enhanced ultrasound (CEUS) for assessing Bosniak III complex renal cystic lesions with histopathological validation. Materials and Methods: 49 patients with CEUS-categorized Bosniak III renal cystic lesions were included in this retrospective study. All patients underwent native B-mode, Color Doppler, contrast-enhanced ultrasound (CEUS) between 2010-2020. Eight and five patients underwent computed tomography (CT) and magnetic resonance imaging (MRI), respectively. Twenty-nine underwent (partial) nephrectomy allowing for histopathological analysis. The applied contrast agent for CEUS was a second-generation blood pool agent. Ultrasonography examinations were performed and interpreted by a single experienced radiologist with more than 15 years of experience (EFSUMB Level 3). Results: CEUS examinations were successfully performed in all included patients without registering any adverse effects. The malignancy rate of CEUS-categorized Bosniak III renal lesions accounted for 66%. Initially, cystic complexity was visualized in native B-mode. In none of the renal lesions hypervascularization was detected in Color Doppler. CEUS allowed for detection of contrast enhancement patterns in all included Bosniak III renal lesions. Delayed wash-out could be detected in 6/29 renal lesions. In two cases of histopathologically confirmed clear-cell RCC, appropriate up-grading from Bosniak IIF to III was achieved by CEUS. Conclusions: CEUS depicts a promising imaging modality for the precise diagnostic workup and stratification of renal cystic lesions according to the Bosniak classification system, thereby helping guidance of adequate clinical management in the future. | ||
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| 700 | 1 | |a Čečatka, Saša |e VerfasserIn |4 aut | |
| 700 | 1 | |a Marschner, Constantin |e VerfasserIn |4 aut | |
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| 700 | 1 | |a Geyer, Thomas |e VerfasserIn |4 aut | |
| 700 | 1 | |a Clevert, Dirk-André |e VerfasserIn |4 aut | |
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