Reduced anterior callosal white matter in risk for psychosis associated with processing speed as a fundamental cognitive impairment
Background - Previous research in psychotic disorders discovered associations between reduced integrity of white matter (WM) in the corpus callosum (CC) and impaired cognitive functions, suggesting processing speed as a central construct. However, it is still largely unexplored to what extent disrup...
Gespeichert in:
| Hauptverfasser: | , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
February 2024
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| In: |
Schizophrenia research
Year: 2024, Jahrgang: 264, Pages: 211-219 |
| ISSN: | 1573-2509 |
| DOI: | 10.1016/j.schres.2023.12.026 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.schres.2023.12.026 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0920996423004723 
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| Verfasserangaben: | Arndt-Lukas Klaassen, Chantal Michel, Miriam Stüble, Michael Kaess, Yosuke Morishima, Jochen Kindler |
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| 245 | 1 | 0 | |a Reduced anterior callosal white matter in risk for psychosis associated with processing speed as a fundamental cognitive impairment |c Arndt-Lukas Klaassen, Chantal Michel, Miriam Stüble, Michael Kaess, Yosuke Morishima, Jochen Kindler |
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| 520 | |a Background - Previous research in psychotic disorders discovered associations between reduced integrity of white matter (WM) in the corpus callosum (CC) and impaired cognitive functions, suggesting processing speed as a central construct. However, it is still largely unexplored to what extent disruption in callosal WM is related to cognitive deficits during the risk stage prior to psychosis. - Methods - To address this gap, we measured the WM integrity in CC by fractional anisotropy (FA) and assessed cognition in 60 clinical-high risk for psychosis (CHR) patients during adolescence/young adulthood and 38 healthy control (HC) subjects. We employed tract based spatial statistics to examine group differences and associations between CC-FA and processing speed, executive function, and spatial working memory. - Results - We revealed deficits in processing speed, executive function, and spatial working memory of CHR patients, and reductions in FA of the genu and the body of the CC (p < 0.05, corrected for multiple comparisons) compared to HC. A mediation analysis using the combined sample (CHR + HC) showed that processing speed mediates the associations between the impaired CC structure and executive function and spatial working memory, respectively. Exploratory analyses between CC-FA and the cognitive domains located associations of processing speed in the genu and the body of CC with distinct spatial distributions of executive function and spatial working memory. - Conclusion - We suggest processing speed as a subordinate cognitive factor contributing to the associations between callosal WM, executive function and working memory. These results extend findings in psychotic disorders to the prior risk stage. | ||
| 650 | 4 | |a Clinical high risk | |
| 650 | 4 | |a Cognition | |
| 650 | 4 | |a corpus callosum | |
| 650 | 4 | |a Diffusion weighted imaging | |
| 650 | 4 | |a Fractional anisotropy | |
| 650 | 4 | |a Processing speed | |
| 700 | 1 | |a Michel, Chantal |e VerfasserIn |4 aut | |
| 700 | 1 | |a Stüble, Miriam |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kaess, Michael |d 1979- |e VerfasserIn |0 (DE-588)136367240 |0 (DE-627)694324248 |0 (DE-576)300984766 |4 aut | |
| 700 | 1 | |a Morishima, Yosuke |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kindler, Jochen |e VerfasserIn |0 (DE-588)1201670624 |0 (DE-627)1685748139 |4 aut | |
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