Cover Image

Can we slow the progression of chronic kidney disease?

Purpose of review - Childhood chronic kidney disease usually progresses towards end-stage renal failure once a critical impairment of renal function has occurred. This process is largely independent of the underlying renal disease. Recent clinical trials have provided evidence that the progressive...

Full description

Saved in:
Bibliographic Details
Main Authors: Wühl, Elke (Author) , Schaefer, Franz (Author)
Format: Article (Journal)
Language:English
Published: April 2010
In: Current opinion in pediatrics
Year: 2010, Volume: 22, Issue: 2, Pages: 170-175
ISSN:1531-698X
DOI:10.1097/MOP.0b013e3283360a5c
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1097/MOP.0b013e3283360a5c
Verlag, lizenzpflichtig, Volltext: https://journals.lww.com/co-pediatrics/fulltext/2010/04000/can_we_slow_the_progression_of_chronic_kidney.10.aspx
Get full text
Author Notes:Elke Wühl, Franz Schaefer

MARC

LEADER 00000caa a2200000 c 4500
001 1887435247
003 DE-627
005 20240703172249.0
007 cr uuu---uuuuu
008 240430s2010 xx |||||o 00| ||eng c
024 7 |a 10.1097/MOP.0b013e3283360a5c  |2 doi 
035 |a (DE-627)1887435247 
035 |a (DE-599)KXP1887435247 
035 |a (OCoLC)1443669602 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 33  |2 sdnb 
100 1 |a Wühl, Elke  |e VerfasserIn  |0 (DE-588)1069939617  |0 (DE-627)823052052  |0 (DE-576)429626134  |4 aut 
245 1 0 |a Can we slow the progression of chronic kidney disease?  |c Elke Wühl, Franz Schaefer 
264 1 |c April 2010 
300 |a 6 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Gesehen am 30.04.2024 
520 |a Purpose of review - Childhood chronic kidney disease usually progresses towards end-stage renal failure once a critical impairment of renal function has occurred. This process is largely independent of the underlying renal disease. Recent clinical trials have provided evidence that the progressive course of chronic kidney disease can be slowed substantially by pharmacological intervention. - Recent findings - Hypertension and proteinuria are the most important independent risk factors for renal disease progression in both adult and pediatric nephropathies. Pharmacological blockade of the renin-angiotensin system provides efficient control of blood pressure and proteinuria, and superior long-term renoprotection compared with other antihypertensive agents. Recent pediatric evidence supports the renoprotective efficacy of tight blood pressure control aiming for the low-normal range. In addition, promising preliminary findings suggest an additional renoprotective potential by correction of metabolic acidosis and hyperuricemia and by administration of antiproliferative and antioxidative drugs. - Summary - Pharmacological renoprotection currently focuses on antihypertensive and antiproteinuric treatment by blockade of the renin-angiotensin system. Intensified blood pressure control can improve 5-year renal survival by 35% in children with chronic kidney disease. Additional complementary strategies under current clinical evaluation bear potential to improve renal survival even further. 
700 1 |a Schaefer, Franz  |d 1961-  |e VerfasserIn  |0 (DE-588)1023365383  |0 (DE-627)718365577  |0 (DE-576)366705598  |4 aut 
773 0 8 |i Enthalten in  |t Current opinion in pediatrics  |d Philadelphia, Pa. : Lippincott Williams & Wilkins, 1989  |g 22(2010), 2 vom: Apr., Seite 170-175  |h Online-Ressource  |w (DE-627)324455801  |w (DE-600)2026978-X  |w (DE-576)093981120  |x 1531-698X  |7 nnas  |a Can we slow the progression of chronic kidney disease? 
773 1 8 |g volume:22  |g year:2010  |g number:2  |g month:04  |g pages:170-175  |g extent:6  |a Can we slow the progression of chronic kidney disease? 
856 4 0 |u https://doi.org/10.1097/MOP.0b013e3283360a5c  |x Verlag  |x Resolving-System  |z lizenzpflichtig  |3 Volltext 
856 4 0 |u https://journals.lww.com/co-pediatrics/fulltext/2010/04000/can_we_slow_the_progression_of_chronic_kidney.10.aspx  |x Verlag  |z lizenzpflichtig  |3 Volltext 
951 |a AR 
992 |a 20240430 
993 |a Article 
994 |a 2010 
998 |g 1023365383  |a Schaefer, Franz  |m 1023365383:Schaefer, Franz  |d 910000  |d 910500  |d 50000  |e 910000PS1023365383  |e 910500PS1023365383  |e 50000PS1023365383  |k 0/910000/  |k 1/910000/910500/  |k 0/50000/  |p 2  |y j 
998 |g 1069939617  |a Wühl, Elke  |m 1069939617:Wühl, Elke  |d 910000  |d 910500  |e 910000PW1069939617  |e 910500PW1069939617  |k 0/910000/  |k 1/910000/910500/  |p 1  |x j 
999 |a KXP-PPN1887435247  |e 451939872X 
BIB |a Y 
SER |a journal 
JSO |a {"person":[{"given":"Elke","display":"Wühl, Elke","family":"Wühl","role":"aut"},{"display":"Schaefer, Franz","role":"aut","family":"Schaefer","given":"Franz"}],"note":["Gesehen am 30.04.2024"],"language":["eng"],"name":{"displayForm":["Elke Wühl, Franz Schaefer"]},"origin":[{"dateIssuedDisp":"April 2010","dateIssuedKey":"2010"}],"id":{"eki":["1887435247"],"doi":["10.1097/MOP.0b013e3283360a5c"]},"recId":"1887435247","type":{"media":"Online-Ressource","bibl":"article-journal"},"physDesc":[{"extent":"6 S."}],"title":[{"title":"Can we slow the progression of chronic kidney disease?","title_sort":"Can we slow the progression of chronic kidney disease?"}],"relHost":[{"disp":"Can we slow the progression of chronic kidney disease?Current opinion in pediatrics","origin":[{"publisher":"Lippincott Williams & Wilkins ; Ovid","dateIssuedDisp":"1989-","publisherPlace":"Philadelphia, Pa. ; [Erscheinungsort nicht ermittelbar]","dateIssuedKey":"1989"}],"recId":"324455801","id":{"issn":["1531-698X"],"zdb":["2026978-X"],"eki":["324455801"]},"type":{"bibl":"periodical","media":"Online-Ressource"},"pubHistory":["1.1989 -"],"note":["Gesehen am 27.01.15"],"language":["eng"],"part":{"text":"22(2010), 2 vom: Apr., Seite 170-175","volume":"22","extent":"6","pages":"170-175","year":"2010","issue":"2"},"physDesc":[{"extent":"Online-Ressource"}],"title":[{"title_sort":"Current opinion in pediatrics","title":"Current opinion in pediatrics"}]}]} 
SRT |a WUEHLELKESCANWESLOWT2010 

Similar Items