Common mechanistic pathways in cancer and heart failure: a scientific roadmap on behalf of the Translational Research Committee of the Heart Failure Association (HFA) of the European Society of Cardiology (ESC)
The co-occurrence of cancer and heart failure (HF) represents a significant clinical drawback as each disease interferes with the treatment of the other. In addition to shared risk factors, a growing body of experimental and clinical evidence reveals numerous commonalities in the biology underlying...
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| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
December 2020
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| In: |
European journal of heart failure
Year: 2020, Volume: 22, Issue: 12, Pages: 2272-2289 |
| ISSN: | 1879-0844 |
| DOI: | 10.1002/ejhf.2029 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.1002/ejhf.2029 Verlag, kostenfrei, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/ejhf.2029 
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| Author Notes: | Rudolf A. de Boer, Jean-Sébastien Hulot, Carlo Gabriele Tocchetti, Joseph Pierre Aboumsallem, Pietro Ameri, Stefan D. Anker, Johann Bauersachs, Edoardo Bertero, Andrew J.S. Coats, Jelena Čelutkienė, Ovidiu Chioncel, Pierre Dodion, Thomas Eschenhagen, Dimitrios Farmakis, Antoni Bayes-Genis, Dirk Jäger, Ewa A. Jankowska, Richard N. Kitsis, Suma H. Konety, James Larkin, Lorenz Lehmann, Daniel J. Lenihan, Christoph Maack, Javid J. Moslehi, Oliver J. Müller, Patrycja Nowak-Sliwinska, Massimo Francesco Piepoli, Piotr Ponikowski, Radek Pudil, Peter P. Rainer, Frank Ruschitzka, Douglas Sawyer, Petar M. Seferovic, Thomas Suter, Thomas Thum, Peter van der Meer, Linda W. Van Laake, Stephan von Haehling, Stephane Heymans, Alexander R. Lyon, and Johannes Backs |
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| 245 | 1 | 0 | |a Common mechanistic pathways in cancer and heart failure |b a scientific roadmap on behalf of the Translational Research Committee of the Heart Failure Association (HFA) of the European Society of Cardiology (ESC) |c Rudolf A. de Boer, Jean-Sébastien Hulot, Carlo Gabriele Tocchetti, Joseph Pierre Aboumsallem, Pietro Ameri, Stefan D. Anker, Johann Bauersachs, Edoardo Bertero, Andrew J.S. Coats, Jelena Čelutkienė, Ovidiu Chioncel, Pierre Dodion, Thomas Eschenhagen, Dimitrios Farmakis, Antoni Bayes-Genis, Dirk Jäger, Ewa A. Jankowska, Richard N. Kitsis, Suma H. Konety, James Larkin, Lorenz Lehmann, Daniel J. Lenihan, Christoph Maack, Javid J. Moslehi, Oliver J. Müller, Patrycja Nowak-Sliwinska, Massimo Francesco Piepoli, Piotr Ponikowski, Radek Pudil, Peter P. Rainer, Frank Ruschitzka, Douglas Sawyer, Petar M. Seferovic, Thomas Suter, Thomas Thum, Peter van der Meer, Linda W. Van Laake, Stephan von Haehling, Stephane Heymans, Alexander R. Lyon, and Johannes Backs |
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| 520 | |a The co-occurrence of cancer and heart failure (HF) represents a significant clinical drawback as each disease interferes with the treatment of the other. In addition to shared risk factors, a growing body of experimental and clinical evidence reveals numerous commonalities in the biology underlying both pathologies. Inflammation emerges as a common hallmark for both diseases as it contributes to the initiation and progression of both HF and cancer. Under stress, malignant and cardiac cells change their metabolic preferences to survive, which makes these metabolic derangements a great basis to develop intersection strategies and therapies to combat both diseases. Furthermore, genetic predisposition and clonal haematopoiesis are common drivers for both conditions and they hold great clinical relevance in the context of personalized medicine. Additionally, altered angiogenesis is a common hallmark for failing hearts and tumours and represents a promising substrate to target in both diseases. Cardiac cells and malignant cells interact with their surrounding environment called stroma. This interaction mediates the progression of the two pathologies and understanding the structure and function of each stromal component may pave the way for innovative therapeutic strategies and improved outcomes in patients. The interdisciplinary collaboration between cardiologists and oncologists is essential to establish unified guidelines. To this aim, pre-clinical models that mimic the human situation, where both pathologies coexist, are needed to understand all the aspects of the bidirectional relationship between cancer and HF. Finally, adequately powered clinical studies, including patients from all ages, and men and women, with proper adjudication of both cancer and cardiovascular endpoints, are essential to accurately study these two pathologies at the same time. | ||
| 650 | 4 | |a Inflammation | |
| 650 | 4 | |a Angiogenesis | |
| 650 | 4 | |a Cancer | |
| 650 | 4 | |a Cardio-oncology | |
| 650 | 4 | |a Cardiotoxicity | |
| 650 | 4 | |a Clonal haematopoiesis | |
| 650 | 4 | |a Extracellular matrix | |
| 650 | 4 | |a Heart failure | |
| 650 | 4 | |a Metabolism | |
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