Implementation and evaluation of a breast cancer disease model using real-world claims data in Germany from 2010 to 2020
Breast cancer is the leading cause of cancer-related mortality among women in Germany and worldwide. This retrospective claims data analysis utilizing data from AOK Baden-Wuerttemberg, a major statutory German health insurance provider, aimed to construct and assess a real-world data breast cancer d...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
2024
|
| In: |
Cancers
Year: 2024, Volume: 16, Issue: 8, Pages: 1-15 |
| ISSN: | 2072-6694 |
| DOI: | 10.3390/cancers16081490 |
| Online Access: | Resolving-System, kostenfrei: https://doi.org/10.3390/cancers16081490 Resolving-System, kostenfrei: https://doi.org/10.25673/117367 
|
| Author Notes: | by Dominik Dannehl, Alexandra von Au, Tobias Engler, Léa Louise Volmer, Raphael Gutsfeld, Johannes Felix Englisch, Markus Hahn, Sabine Hawighorst-Knapstein, Ariane Chaudhuri, Armin Bauer, Markus Wallwiener, Florin-Andrei Taran, Diethelm Wallwiener, Sara Yvonne Brucker, Stephanie Wallwiener, Andreas Daniel Hartkopf and Tjeerd Maarten Hein Dijkstra |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1888243929 | ||
| 003 | DE-627 | ||
| 005 | 20250716211910.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240510s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.3390/cancers16081490 |2 doi | |
| 024 | 7 | |a 10.25673/117367 |2 doi | |
| 035 | |a (DE-627)1888243929 | ||
| 035 | |a (DE-599)KXP1888243929 | ||
| 035 | |a (OCoLC)1528014138 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Dannehl, Dominik |d 1994- |e VerfasserIn |0 (DE-588)119681452X |0 (DE-627)167864059X |4 aut | |
| 245 | 1 | 0 | |a Implementation and evaluation of a breast cancer disease model using real-world claims data in Germany from 2010 to 2020 |c by Dominik Dannehl, Alexandra von Au, Tobias Engler, Léa Louise Volmer, Raphael Gutsfeld, Johannes Felix Englisch, Markus Hahn, Sabine Hawighorst-Knapstein, Ariane Chaudhuri, Armin Bauer, Markus Wallwiener, Florin-Andrei Taran, Diethelm Wallwiener, Sara Yvonne Brucker, Stephanie Wallwiener, Andreas Daniel Hartkopf and Tjeerd Maarten Hein Dijkstra |
| 264 | 1 | |c 2024 | |
| 300 | |b Diagramme | ||
| 300 | |a 15 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 520 | |a Breast cancer is the leading cause of cancer-related mortality among women in Germany and worldwide. This retrospective claims data analysis utilizing data from AOK Baden-Wuerttemberg, a major statutory German health insurance provider, aimed to construct and assess a real-world data breast cancer disease model. The study included 27,869 female breast cancer patients and 55,738 age-matched controls, analyzing data from 2010 to 2020. Three distinct breast cancer stages were analyzed: Stage A (early breast cancer without lymph node involvement), Stage B (early breast cancer with lymph node involvement), and Stage C (primary distant metastatic breast cancer). Tumor subtypes were estimated based on the prescription of antihormonal or HER2-targeted therapy. The study established that 77.9% of patients had HR+ breast cancer and 9.8% HER2+; HR+/HER2- was the most common subtype (70.9%). Overall survival (OS) analysis demonstrated significantly lower survival rates for stages B and C than for controls, with 5-year OS rates ranging from 79.3% for stage B to 35.4% for stage C. OS rates were further stratified by tumor subtype and stage, revealing varying prognoses. Distant recurrence-free survival (DRFS) analysis showed higher recurrence rates in stage B than in stage A, with HR-/HER2- displaying the worst DRFS. This study, the first to model breast cancer subtypes, stages, and outcomes using German claims data, provides valuable insights into real-world breast cancer epidemiology and demonstrates that this breast cancer disease model has the potential to be representative of treatment outcomes. | ||
| 540 | |q DE-3 |a Namensnennung 4.0 International |f CC BY 4.0 |2 cc |u https://creativecommons.org/licenses/by/4.0/ | ||
| 700 | 1 | |a Au, Alexandra von |d 1985- |e VerfasserIn |0 (DE-588)1022333909 |0 (DE-627)716953366 |0 (DE-576)362850666 |4 aut | |
| 700 | 1 | |a Engler, Tobias |e VerfasserIn |0 (DE-588)1280560223 |0 (DE-627)1833846389 |4 aut | |
| 700 | 1 | |a Volmer, Léa |d 1992- |e VerfasserIn |0 (DE-588)1163666602 |0 (DE-627)1028028237 |0 (DE-576)508125375 |4 aut | |
| 700 | 1 | |a Gutsfeld, Raphael |e VerfasserIn |4 aut | |
| 700 | 1 | |a Englisch, Johannes Felix |e VerfasserIn |4 aut | |
| 700 | 1 | |a Hahn, Markus |e VerfasserIn |0 (DE-588)1029201404 |0 (DE-627)732591805 |0 (DE-576)377137138 |4 aut | |
| 700 | 1 | |8 1\p |a Hawighorst, Sabine |d 1958- |e VerfasserIn |0 (DE-588)111129958 |0 (DE-627)50795663X |0 (DE-576)289693500 |4 aut | |
| 700 | 1 | |a Chaudhuri, Ariane |d 1977- |e VerfasserIn |0 (DE-588)142178454 |0 (DE-627)704163438 |0 (DE-576)328153419 |4 aut | |
| 700 | 1 | |a Bauer, Armin |e VerfasserIn |4 aut | |
| 700 | 1 | |a Wallwiener, Markus |d 1980- |e VerfasserIn |0 (DE-588)134044827 |0 (DE-627)692043934 |0 (DE-576)27468327X |4 aut | |
| 700 | 1 | |a Ţăran, Florin-Andrei |d 1978- |e VerfasserIn |0 (DE-588)13392792X |0 (DE-627)558737587 |0 (DE-576)278313485 |4 aut | |
| 700 | 1 | |a Wallwiener, Diethelm |d 1954- |e VerfasserIn |0 (DE-588)121922413 |0 (DE-627)081622147 |0 (DE-576)16771726X |4 aut | |
| 700 | 1 | |a Brucker, Sara |d 1974- |e VerfasserIn |0 (DE-588)122129660 |0 (DE-627)081754264 |0 (DE-576)293107386 |4 aut | |
| 700 | 1 | |a Wallwiener, Stephanie |d 1981- |e VerfasserIn |0 (DE-588)137226276 |0 (DE-627)591025329 |0 (DE-576)302823662 |4 aut | |
| 700 | 1 | |a Hartkopf, Andreas |d 1979- |e VerfasserIn |0 (DE-588)139124101 |0 (DE-627)703216279 |0 (DE-576)309901596 |4 aut | |
| 700 | 1 | |a Dijkstra, Tjeerd Maarten Hein |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Cancers |d Basel : MDPI, 2009 |g 16(2024), 8, Artikel-ID 1490, Seite 1-15 |h Online-Ressource |w (DE-627)614095670 |w (DE-600)2527080-1 |w (DE-576)313958548 |x 2072-6694 |7 nnas |a Implementation and evaluation of a breast cancer disease model using real-world claims data in Germany from 2010 to 2020 |
| 773 | 1 | 8 | |g volume:16 |g year:2024 |g number:8 |g elocationid:1490 |g pages:1-15 |g extent:15 |a Implementation and evaluation of a breast cancer disease model using real-world claims data in Germany from 2010 to 2020 |
| 856 | 4 | 0 | |u https://doi.org/10.3390/cancers16081490 |x Resolving-System |z kostenfrei |7 0 |
| 856 | 4 | 0 | |u https://doi.org/10.25673/117367 |x Resolving-System |z kostenfrei |7 0 |
| 883 | |8 1\p |a cgwrk |d 20241001 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 951 | |a AR | ||
| 992 | |a 20250219 | ||
| 993 | |a Article | ||
| 994 | |a 2024 | ||
| 998 | |g 137226276 |a Wallwiener, Stephanie |m 137226276:Wallwiener, Stephanie |d 50000 |e 50000PW137226276 |k 0/50000/ |p 15 | ||
| 998 | |g 134044827 |a Wallwiener, Markus |m 134044827:Wallwiener, Markus |d 50000 |e 50000PW134044827 |k 0/50000/ |p 11 | ||
| 998 | |g 1022333909 |a Au, Alexandra von |m 1022333909:Au, Alexandra von |d 910000 |d 910400 |e 910000PA1022333909 |e 910400PA1022333909 |k 0/910000/ |k 1/910000/910400/ |p 2 | ||
| 999 | |a KXP-PPN1888243929 |e 4666683259 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"person":[{"given":"Dominik","display":"Dannehl, Dominik","family":"Dannehl","role":"aut"},{"display":"Au, Alexandra von","given":"Alexandra von","role":"aut","family":"Au"},{"family":"Engler","role":"aut","display":"Engler, Tobias","given":"Tobias"},{"display":"Volmer, Léa","given":"Léa","family":"Volmer","role":"aut"},{"family":"Gutsfeld","role":"aut","given":"Raphael","display":"Gutsfeld, Raphael"},{"family":"Englisch","role":"aut","given":"Johannes Felix","display":"Englisch, Johannes Felix"},{"role":"aut","family":"Hahn","given":"Markus","display":"Hahn, Markus"},{"family":"Hawighorst","role":"aut","display":"Hawighorst, Sabine","given":"Sabine"},{"family":"Chaudhuri","role":"aut","display":"Chaudhuri, Ariane","given":"Ariane"},{"role":"aut","family":"Bauer","given":"Armin","display":"Bauer, Armin"},{"display":"Wallwiener, Markus","given":"Markus","role":"aut","family":"Wallwiener"},{"given":"Florin-Andrei","display":"Ţăran, Florin-Andrei","family":"Ţăran","role":"aut"},{"role":"aut","family":"Wallwiener","display":"Wallwiener, Diethelm","given":"Diethelm"},{"display":"Brucker, Sara","given":"Sara","family":"Brucker","role":"aut"},{"family":"Wallwiener","role":"aut","display":"Wallwiener, Stephanie","given":"Stephanie"},{"role":"aut","family":"Hartkopf","display":"Hartkopf, Andreas","given":"Andreas"},{"display":"Dijkstra, Tjeerd Maarten Hein","given":"Tjeerd Maarten Hein","role":"aut","family":"Dijkstra"}],"recId":"1888243929","language":["eng"],"name":{"displayForm":["by Dominik Dannehl, Alexandra von Au, Tobias Engler, Léa Louise Volmer, Raphael Gutsfeld, Johannes Felix Englisch, Markus Hahn, Sabine Hawighorst-Knapstein, Ariane Chaudhuri, Armin Bauer, Markus Wallwiener, Florin-Andrei Taran, Diethelm Wallwiener, Sara Yvonne Brucker, Stephanie Wallwiener, Andreas Daniel Hartkopf and Tjeerd Maarten Hein Dijkstra"]},"origin":[{"dateIssuedDisp":"2024","dateIssuedKey":"2024"}],"relHost":[{"physDesc":[{"extent":"Online-Ressource"}],"id":{"zdb":["2527080-1"],"eki":["614095670"],"issn":["2072-6694"]},"title":[{"title_sort":"Cancers","title":"Cancers"}],"origin":[{"publisher":"MDPI","dateIssuedDisp":"2009-","dateIssuedKey":"2009","publisherPlace":"Basel"}],"name":{"displayForm":["Molecular Diversity Preservation International (MDPI)"]},"recId":"614095670","disp":"Implementation and evaluation of a breast cancer disease model using real-world claims data in Germany from 2010 to 2020Cancers","type":{"media":"Online-Ressource","bibl":"periodical"},"part":{"extent":"15","pages":"1-15","issue":"8","text":"16(2024), 8, Artikel-ID 1490, Seite 1-15","volume":"16","year":"2024"},"language":["eng"],"note":["Gesehen am 27.05.2020"],"pubHistory":["1.2009 -"]}],"id":{"doi":["10.3390/cancers16081490","10.25673/117367"],"eki":["1888243929"]},"physDesc":[{"extent":"15 S.","noteIll":"Diagramme"}],"title":[{"title_sort":"Implementation and evaluation of a breast cancer disease model using real-world claims data in Germany from 2010 to 2020","title":"Implementation and evaluation of a breast cancer disease model using real-world claims data in Germany from 2010 to 2020"}],"type":{"media":"Online-Ressource","bibl":"article-journal"}} | ||
| SRT | |a DANNEHLDOMIMPLEMENTA2024 | ||