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Effective reprogramming of patient-derived M2-polarized glioblastoma-associated mcroglia/macrophages by treatment with GW2580

Purpose: Targeting immunosuppressive and pro-tumorigenic glioblastoma (GBM)-associated macrophages and microglial cells (GAM) has great potential to improve patient outcomes. Colonystimulating factor-1 receptor (CSF1R) has emerged as a promising target for reprograming anti-inflammatory M2-like GAMs....

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Main Authors: Fermi, Valentina (Author) , Warta, Rolf (Author) , Wöllner, Amélie (Author) , Lotsch, Catharina (Author) , Jassowicz, Lena (Author) , Rapp, Carmen (Author) , Knoll, Maximilian (Author) , Jungwirth, Gerhard (Author) , Jungk, Christine (Author) , Dao Trong, Huy Philip (Author) , Deimling, Andreas von (Author) , Abdollahi, Amir (Author) , Unterberg, Andreas (Author) , Herold-Mende, Christel (Author)
Format: Article (Journal)
Language:English
Published: November 14, 2023
In: Clinical cancer research
Year: 2023, Volume: 29, Issue: 22, Pages: 4685-4697
ISSN:1557-3265
DOI:10.1158/1078-0432.CCR-23-0576
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1158/1078-0432.CCR-23-0576
Verlag, lizenzpflichtig, Volltext: https://aacrjournals.org/clincancerres/article/29/22/4685/729949/Effective-Reprogramming-of-Patient-Derived-M2
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Author Notes:Valentina Fermi, Rolf Warta, Amélie Wöllner, Catharina Lotsch, Lena Jassowicz, Carmen Rapp, Maximilian Knoll, Gerhard Jungwirth, Christine Jungk, Philip Dao Trong, Andreas Von Deimling, Amir Abdollahi, Andreas Unterberg, and Christel Herold-Mende
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Summary:Purpose: Targeting immunosuppressive and pro-tumorigenic glioblastoma (GBM)-associated macrophages and microglial cells (GAM) has great potential to improve patient outcomes. Colonystimulating factor-1 receptor (CSF1R) has emerged as a promising target for reprograming anti-inflammatory M2-like GAMs. However, treatment data on patient-derived, tumor-educated GAMs and their influence on the adaptive immunity are lacking.
Item Description:Gesehen am 13.05.2024
Physical Description:Online Resource
ISSN:1557-3265
DOI:10.1158/1078-0432.CCR-23-0576

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