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Consistency of the “central vein sign” in chronic multiple sclerosis lesions

Background - In recent years, there has been an increasing interest in the central vein sign (CVS) as a new imaging marker and previous cross-sectional studies demonstrated that the CVS has the potential to discriminate multiple sclerosis (MS) lesions from non-MS lesions. The aim of this study was t...

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Main Authors: Reichl, Matthias (Author) , Wittayer, Matthias Sebastian (Author) , Weber, Claudia Ellen (Author) , Platten, Michael (Author) , Gass, Achim (Author) , Eisele, Philipp (Author)
Format: Article (Journal)
Language:English
Published: February 2022
In: Multiple Sclerosis and Related Disorders
Year: 2022, Volume: 58, Pages: 1-4
ISSN:2211-0356
DOI:10.1016/j.msard.2022.103530
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.msard.2022.103530
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S2211034822000451
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Author Notes:Matthias Reichl, Matthias Wittayer, Claudia E. Weber, Michael Platten, Achim Gass, Philipp Eisele

MARC

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520 |a Background - In recent years, there has been an increasing interest in the central vein sign (CVS) as a new imaging marker and previous cross-sectional studies demonstrated that the CVS has the potential to discriminate multiple sclerosis (MS) lesions from non-MS lesions. The aim of this study was to investigate the consistency of the CVS in a longitudinal magnetic resonance imaging (MRI) data set. - Methods - 3T MRI datasets from seventy-one people with MS acquired at baseline and after 12 months-follow-up were analyzed. Chronic lesions were identified on fluid-attenuated inversion recovery (FLAIR) images. Co-registered susceptibility-weighted/FLAIR images were analyzed for the presence of a CVS at baseline and follow-up. - Results - A total of 183 chronic lesions were included in the final analysis. At baseline MRI, a CVS was detectable in 141/183 (77%) lesions. Overall, the CVS was consistent in 114/141 (81%) lesions (Cohen's kappa = 0.46, standard error = 0.07). - Conclusion - The CVS is a rather stable feature in chronic MS lesions and therefore represents a robust imaging marker that could increase the specificity of MRI in MS. 
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