Incidence and presentation of new-onset type 1 diabetes in children and adolescents from Germany during the COVID-19 pandemic 2020 and 2021: current data from the DPV Registry
Aims - To determine whether the incidence of type 1 diabetes mellitus (T1D), autoantibody-negative diabetes, and diabetic ketoacidosis (DKA) at diabetes onset in 2020 and 2021 changed when compared to long-standing trends. - Methods - Our study is based on diabetes manifestation data of the 0.5-<...
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| Hauptverfasser: | , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
March 2023
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| In: |
Diabetes research and clinical practice
Year: 2023, Jahrgang: 197, Pages: 1-9 |
| ISSN: | 1872-8227 |
| DOI: | 10.1016/j.diabres.2023.110559 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.diabres.2023.110559 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0168822723000347 
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| Verfasserangaben: | C. Baechle, A. Eckert, C. Kamrath, A. Neu, U. Manuwald, S. Thiele-Schmitz, O. Weidler, S. Knauer-Fischer, J. Rosenbauer, R.W. Holl |
MARC
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| 245 | 1 | 0 | |a Incidence and presentation of new-onset type 1 diabetes in children and adolescents from Germany during the COVID-19 pandemic 2020 and 2021 |b current data from the DPV Registry |c C. Baechle, A. Eckert, C. Kamrath, A. Neu, U. Manuwald, S. Thiele-Schmitz, O. Weidler, S. Knauer-Fischer, J. Rosenbauer, R.W. Holl |
| 264 | 1 | |c March 2023 | |
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| 500 | |a Online verfügbar: 8. Februar 2023, Artikelversion: 19. Februar 2023 | ||
| 500 | |a Gesehen am 21.05.2024 | ||
| 520 | |a Aims - To determine whether the incidence of type 1 diabetes mellitus (T1D), autoantibody-negative diabetes, and diabetic ketoacidosis (DKA) at diabetes onset in 2020 and 2021 changed when compared to long-standing trends. - Methods - Our study is based on diabetes manifestation data of the 0.5-<18-year-old children/adolescents from the German multicenter Diabetes Prospective Follow-up Registry. Based on long-term pre-pandemic trends from 2011 to 2019, we estimated adjusted incidence rate ratios (IRR) for T1D and DKA, and prevalence rate ratios (PRR) regarding autoantibody status with 95 % confidence intervals (CI) for the years 2020 and 2021 (observed versus predicted rates), using multivariable negative binomial or beta-binomial regression, respectively. - Results - We analyzed data of 30,840 children and adolescents with new-onset T1D. The observed incidences were significantly higher than the predicted incidences (IRR2020 1.13 [1.08-1.19]; IRR2021 1.20 [1.15-1.26]). The prevalence of autoantibody-negative diabetes did not change (PRR2020 0.91 [0.75-1.10]; PRR2021 1.03 [0.86-1.24]). The incidence of DKA during the pandemic was higher than predicted (IRR2020 1.34 [1.23-1.46]; IRR2021 1.37 [1.26-1.49]). - Conclusions - An increase in the incidences of T1D and DKA, but not of autoantibody-negative diabetes was observed during both pandemic years. Further monitoring and efforts for DKA prevention at onset are necessary. | ||
| 650 | 4 | |a Adolescents | |
| 650 | 4 | |a Diabetic ketoacidosis | |
| 650 | 4 | |a Germany | |
| 650 | 4 | |a Incidence | |
| 650 | 4 | |a Registry | |
| 650 | 4 | |a Type 1 diabetes | |
| 700 | 1 | |a Eckert, A. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kamrath, C. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Neu, A. |e VerfasserIn |4 aut | |
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| 700 | 1 | |a Thiele-Schmitz, S. |e VerfasserIn |4 aut | |
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| 700 | 1 | |a Rosenbauer, J. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Holl, R. W. |e VerfasserIn |4 aut | |
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