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Prediction of dementia of Alzheimer type by different types of subjective cognitive decline

Introduction Subjective cognitive decline (SCD) is a risk condition for dementia, including dementia of Alzheimer type (DAT). Methods We report sensitivity, specificity, positive and negative predictive values (PPV, NPV) for conversion to all-cause dementia, and DAT in different SCD types (decline i...

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Main Authors: Jessen, Frank (Author) , Kleineidam, Luca (Author) , Wolfsgruber, Steffen (Author) , Bickel, Horst (Author) , Brettschneider, Christian (Author) , Fuchs, Angela (Author) , Kaduszkiewicz, Hanna (Author) , König, Hans-Helmut (Author) , Mallon, Tina (Author) , Mamone, Silke (Author) , Pabst, Alexander (Author) , Pentzek, Michael (Author) , Roehr, Susanne (Author) , Weeg, Dagmar (Author) , Jochen, Werle (Author) , Weyerer, Siegfried (Author) , Wiese, Birgitt (Author) , Maier, Wolfgang (Author) , Scherer, Martin (Author) , Riedel-Heller, Steffi (Author) , Wagner, Michael (Author)
Format: Article (Journal)
Language:English
Published: December 2020
In: Alzheimer's and dementia
Year: 2020, Volume: 16, Issue: 12, Pages: 1745-1749
ISSN:1552-5279
DOI:10.1002/alz.12163
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1002/alz.12163
Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/alz.12163
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Author Notes:Frank Jessen, Luca Kleineidam, Steffen Wolfsgruber, Horst Bickel, Christian Brettschneider, Angela Fuchs, Hanna Kaduszkiewicz, Hans-Helmut König, Tina Mallon, Silke Mamone, Alexander Pabst, Michael Pentzek, Susanne Roehr, Dagmar Weeg, Werle Jochen, Siegfried Weyerer, Birgitt Wiese, Wolfgang Maier, Martin Scherer, Steffi Riedel-Heller, Michael Wagner

MARC

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520 |a Introduction Subjective cognitive decline (SCD) is a risk condition for dementia, including dementia of Alzheimer type (DAT). Methods We report sensitivity, specificity, positive and negative predictive values (PPV, NPV) for conversion to all-cause dementia, and DAT in different SCD types (decline in memory, assocated worries, longitudinal consitency, of the AgeCoDe study (n = 2.402, 12 years follow-up). Results 82.7% of those converting to any dementia and 84.4% of those converting with DAT at follow-up, reported memory decline and fulfilled criteria of SCD at least at one time point before. SCD with worries at two consecutive time points showed a specificity of 92.2% for any dementia and also for DAT as well as a PPV of 44.3% for any dementia and of 36.9% for DAT at follow-up at the expense of low sensitivity. Discussion Different SCD subtypes were either sensitive or specific for future all-cause dementia and DAT in cognitively unimpaired individuals. Modest PPV of the most specific SCD subtypes were achieved in this low prevalence population. 
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