Outcome after cytoreductive surgery combined with hyperthermic intrathoracic chemotherapy in patients with secondary pleural metastases
Background: The role of cytoreductive surgery combined with hyperthermic intrathoracic chemotherapy (CRS+HITOC) for patients with secondary pleural metastases has scarcely been investigated. Patients and Methods: We conducted a retrospective, multicentre study investigating the outcome of CRS+HITOC...
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| Hauptverfasser: | , , , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
28 November 2023
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| In: |
Frontiers in oncology
Year: 2023, Jahrgang: 13, Pages: 1-9 |
| ISSN: | 2234-943X |
| DOI: | 10.3389/fonc.2023.1259779 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.3389/fonc.2023.1259779 Verlag, lizenzpflichtig, Volltext: https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2023.1259779/full 
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| Verfasserangaben: | Mohamed Hassan, Julia Zimmermann, Severin Schmid, Bernward Passlick, Julia Kovács, Rudolf Hatz, Hauke Winter, Laura V. Klotz, Martin E. Eichhorn, Till Markowiak, Karolina Müller, Gunnar Huppertz, Michael Koller, Hans-Stefan Hofmann and Michael Ried |
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| 245 | 1 | 0 | |a Outcome after cytoreductive surgery combined with hyperthermic intrathoracic chemotherapy in patients with secondary pleural metastases |c Mohamed Hassan, Julia Zimmermann, Severin Schmid, Bernward Passlick, Julia Kovács, Rudolf Hatz, Hauke Winter, Laura V. Klotz, Martin E. Eichhorn, Till Markowiak, Karolina Müller, Gunnar Huppertz, Michael Koller, Hans-Stefan Hofmann and Michael Ried |
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| 520 | |a Background: The role of cytoreductive surgery combined with hyperthermic intrathoracic chemotherapy (CRS+HITOC) for patients with secondary pleural metastases has scarcely been investigated. Patients and Methods: We conducted a retrospective, multicentre study investigating the outcome of CRS+HITOC for 31 patients with pleural metastases from different primary tumours in four high-volume departments of thoracic surgery in Germany. The primary endpoint was overall survival (OS). Secondary endpoints included postoperative complications and recurrence/progression-free survival (RFS/PFS). Results: The primary tumour was non-small cell lung cancer in 12 (39%), ovarian cancer in 5 (16%), sarcoma in 3 (10%), pseudomyxoma peritonei in 3 (10%), and others in 8 (26%) patients. A macroscopic complete resection (R/1) could be achieved in 28 (90%) patients. Major postoperative complications as classified by Clavien-Dindo (III-V) were observed in 11 (35%) patients. The postoperative mortality rate was 10% (n=3). A total of 13 patients received additive chemotherapy (42%). The median time of follow up was 30 months (95% CI = 17- 43). The median OS was 39 months (95% CI: 34-44 months) with 1-month, 3-month, 1-, 3-, and 5-year survival estimates of 97%, 89%, 77%, 66%, and 41%. There was a significantly prolonged OS in patients who received additive chemotherapy compared to patients with only CRS+HITOC (median OS 69 <italic>vs</italic> 38 months; p= 0.048). The median RFS was 14 months (95% CI: 7-21 months). Conclusions: We observed that CRS+HITOC is a feasible approach with reasonable complications and prolonged survival as a part of multimodal concept for highly selected patients with secondary pleural metastases. | ||
| 650 | 4 | |a cytoreductive surgery2 | |
| 650 | 4 | |a HITOC1 | |
| 650 | 4 | |a hyperthermic intrathoracic chemotherapy5 | |
| 650 | 4 | |a non-small cell lung cancer4 | |
| 650 | 4 | |a pleural metastases3 | |
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