Detrimental impact of immunosuppressive burden on clinical course in patients with Cytomegalovirus infection after liver transplantation
Introduction Cytomegalovirus (CMV)-infection and reactivation remain a relevant complication after liver transplantation (LT). The recipient and donor serum CMV-IgG-status has been established for risk stratification when choosing various pharmaceutical regimens for CMV-prophylaxis in the last two d...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
27 November 2023
|
| In: |
Transplant infectious disease
Year: 2024, Jahrgang: 26, Heft: 1, Pages: 1-14 |
| ISSN: | 1399-3062 |
| DOI: | 10.1111/tid.14196 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1111/tid.14196 Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/tid.14196 
|
| Verfasserangaben: | Ramin Raul Ossami Saidy, Stefanie Kollar, Zoltan Czigany, Luca Dittrich, Nathanael Raschzok, Brigitta Globke, Wenzel Schöning, Robert Öllinger, Georg Lurje, Johann Pratschke, Dennis Eurich, Deniz Uluk |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 188989012X | ||
| 003 | DE-627 | ||
| 005 | 20240703182030.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240527s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1111/tid.14196 |2 doi | |
| 035 | |a (DE-627)188989012X | ||
| 035 | |a (DE-599)KXP188989012X | ||
| 035 | |a (OCoLC)1443678669 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Ossami Saidy, Ramin Raul |d 1988- |e VerfasserIn |0 (DE-588)1163633526 |0 (DE-627)1027959652 |0 (DE-576)508116201 |4 aut | |
| 245 | 1 | 0 | |a Detrimental impact of immunosuppressive burden on clinical course in patients with Cytomegalovirus infection after liver transplantation |c Ramin Raul Ossami Saidy, Stefanie Kollar, Zoltan Czigany, Luca Dittrich, Nathanael Raschzok, Brigitta Globke, Wenzel Schöning, Robert Öllinger, Georg Lurje, Johann Pratschke, Dennis Eurich, Deniz Uluk |
| 264 | 1 | |c 27 November 2023 | |
| 300 | |a 14 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 27.05.2024 | ||
| 520 | |a Introduction Cytomegalovirus (CMV)-infection and reactivation remain a relevant complication after liver transplantation (LT). The recipient and donor serum CMV-IgG-status has been established for risk stratification when choosing various pharmaceutical regimens for CMV-prophylaxis in the last two decades. However, factors influencing course of CMV-infection in LT remain largely unknown. In this study, the impact of immunosuppressive regimen was examined in a large cohort of patients. Methods All patients that underwent primary LT between 2006 and 2018 at the Charité-Universitaetsmedizin, Berlin, were included. Clinical course as well as histological and laboratory findings of patients were analyzed our prospectively maintained database. Univariate and multivariate regression analysis for impact of variables on CMV-occurrence was conducted, and survival was examined using Kaplan-Meier analysis. Results Overall, 867 patients were included in the final analysis. CMV-infection was diagnosed in 325 (37.5%) patients after transplantation. Significantly improved overall survival was observed in these patients (Log rank = 0.03). As shown by correlation and regression tree classification and regression tree analysis, the recipient/donor CMV-IgG-status with either positivity had the largest influence on CMV-occurrence. Analysis of immunosuppressive burden did not reveal statistical impact on CMV-infection, but statistically significant inverse correlation of cumulative tacrolimus trough levels and survival was found (Log rank < .001). Multivariate analysis confirmed these findings (p = .02). Discussion CMV-infection remains of clinical importance after LT. Undergone CMV-infection of either recipient or donor requires prophylactic treatment. Additionally, we found a highly significant, dosage-dependent impact of immunosuppression (IS) on long-term outcomes for these patients, underlying the importance of minimization of IS in liver transplant recipients. | ||
| 700 | 1 | |a Kollar, Stefanie |e VerfasserIn |4 aut | |
| 700 | 1 | |a Czigány, Zoltán |d 1988- |e VerfasserIn |0 (DE-588)1184630658 |0 (DE-627)1663681856 |4 aut | |
| 700 | 1 | |a Dittrich, Luca |e VerfasserIn |0 (DE-588)1239090072 |0 (DE-627)1767135688 |4 aut | |
| 700 | 1 | |a Raschzok, Nathanael Johannes |d 1983- |e VerfasserIn |0 (DE-588)1131572955 |0 (DE-627)886168953 |0 (DE-576)488308011 |4 aut | |
| 700 | 1 | |a Globke, Brigitta |d 1983- |e VerfasserIn |0 (DE-588)1078460000 |0 (DE-627)838746195 |0 (DE-576)451524802 |4 aut | |
| 700 | 1 | |a Schöning, Wenzel |e VerfasserIn |0 (DE-588)1148768165 |0 (DE-627)1009166972 |0 (DE-576)496416480 |4 aut | |
| 700 | 1 | |a Öllinger, Robert |e VerfasserIn |0 (DE-588)1082240966 |0 (DE-627)1761923188 |0 (DE-576)455266182 |4 aut | |
| 700 | 1 | |a Lurje, Georg |d 1979- |e VerfasserIn |0 (DE-588)136689949 |0 (DE-627)694581410 |0 (DE-576)301211744 |4 aut | |
| 700 | 1 | |a Pratschke, Johann |d 1965- |e VerfasserIn |0 (DE-588)115663827 |0 (DE-627)077392337 |0 (DE-576)290007097 |4 aut | |
| 700 | 1 | |a Eurich, Dennis |d 1977- |e VerfasserIn |0 (DE-588)133101355 |0 (DE-627)534489176 |0 (DE-576)272303097 |4 aut | |
| 700 | 1 | |a Uluk, Deniz |e VerfasserIn |0 (DE-588)1298949785 |0 (DE-627)1855107600 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Transplant infectious disease |d Oxford [u.a.] : Wiley-Blackwell, 1999 |g 26(2024), 1, Artikel-ID e14196, Seite 1-14 |h Online-Ressource |w (DE-627)32049070X |w (DE-600)2010983-0 |w (DE-576)091169771 |x 1399-3062 |7 nnas |a Detrimental impact of immunosuppressive burden on clinical course in patients with Cytomegalovirus infection after liver transplantation |
| 773 | 1 | 8 | |g volume:26 |g year:2024 |g number:1 |g elocationid:e14196 |g pages:1-14 |g extent:14 |a Detrimental impact of immunosuppressive burden on clinical course in patients with Cytomegalovirus infection after liver transplantation |
| 856 | 4 | 0 | |u https://doi.org/10.1111/tid.14196 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u https://onlinelibrary.wiley.com/doi/abs/10.1111/tid.14196 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20240527 | ||
| 993 | |a Article | ||
| 994 | |a 2023 | ||
| 998 | |g 1184630658 |a Czigany, Zoltan |m 1184630658:Czigany, Zoltan |d 910000 |d 910200 |e 910000PC1184630658 |e 910200PC1184630658 |k 0/910000/ |k 1/910000/910200/ |p 3 | ||
| 999 | |a KXP-PPN188989012X |e 4529937399 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"language":["eng"],"note":["Gesehen am 27.05.2024"],"recId":"188989012X","physDesc":[{"extent":"14 S."}],"relHost":[{"disp":"Detrimental impact of immunosuppressive burden on clinical course in patients with Cytomegalovirus infection after liver transplantationTransplant infectious disease","title":[{"subtitle":"an official journal of the Transplantation Society","title":"Transplant infectious disease","title_sort":"Transplant infectious disease"}],"origin":[{"dateIssuedDisp":"1999-","dateIssuedKey":"1999","publisherPlace":"Oxford [u.a.] ; Copenhagen ; Oxford [u.a.]","publisher":"Wiley-Blackwell ; Munksgaard ; Blackwell"}],"part":{"extent":"14","volume":"26","issue":"1","pages":"1-14","year":"2024","text":"26(2024), 1, Artikel-ID e14196, Seite 1-14"},"id":{"zdb":["2010983-0"],"doi":["10.1111/(ISSN)1399-3062"],"eki":["32049070X"],"issn":["1399-3062"]},"language":["eng"],"pubHistory":["1.1999 -"],"type":{"bibl":"periodical","media":"Online-Ressource"},"note":["Gesehen am 17.03.04"],"physDesc":[{"extent":"Online-Ressource"}],"recId":"32049070X"}],"title":[{"title_sort":"Detrimental impact of immunosuppressive burden on clinical course in patients with Cytomegalovirus infection after liver transplantation","title":"Detrimental impact of immunosuppressive burden on clinical course in patients with Cytomegalovirus infection after liver transplantation"}],"name":{"displayForm":["Ramin Raul Ossami Saidy, Stefanie Kollar, Zoltan Czigany, Luca Dittrich, Nathanael Raschzok, Brigitta Globke, Wenzel Schöning, Robert Öllinger, Georg Lurje, Johann Pratschke, Dennis Eurich, Deniz Uluk"]},"type":{"media":"Online-Ressource","bibl":"article-journal"},"person":[{"given":"Ramin Raul","role":"aut","display":"Ossami Saidy, Ramin Raul","family":"Ossami Saidy"},{"role":"aut","display":"Kollar, Stefanie","family":"Kollar","given":"Stefanie"},{"given":"Zoltán","role":"aut","display":"Czigány, Zoltán","family":"Czigány"},{"given":"Luca","family":"Dittrich","role":"aut","display":"Dittrich, Luca"},{"given":"Nathanael Johannes","display":"Raschzok, Nathanael Johannes","role":"aut","family":"Raschzok"},{"given":"Brigitta","display":"Globke, Brigitta","role":"aut","family":"Globke"},{"given":"Wenzel","display":"Schöning, Wenzel","role":"aut","family":"Schöning"},{"family":"Öllinger","role":"aut","display":"Öllinger, Robert","given":"Robert"},{"role":"aut","display":"Lurje, Georg","family":"Lurje","given":"Georg"},{"role":"aut","display":"Pratschke, Johann","family":"Pratschke","given":"Johann"},{"given":"Dennis","role":"aut","display":"Eurich, Dennis","family":"Eurich"},{"family":"Uluk","display":"Uluk, Deniz","role":"aut","given":"Deniz"}],"id":{"eki":["188989012X"],"doi":["10.1111/tid.14196"]},"origin":[{"dateIssuedDisp":"27 November 2023","dateIssuedKey":"2023"}]} | ||
| SRT | |a OSSAMISAIDDETRIMENTA2720 | ||