7-year efficacy and safety of iStent inject trabecular micro-bypass in combined and standalone usage
Introduction: This study evaluated 7-year effectiveness and safety of second-generation trabecular micro-bypass implantation (iStent inject) either in combination with cataract surgery or as a standalone procedure (Combined or Standalone subgroups, respectively) in eyes with open-angle glaucoma. Met...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
16 February 2024
|
| In: |
Advances in therapy
Year: 2024, Volume: 41, Issue: 4, Pages: 1462-1480 |
| ISSN: | 1865-8652 |
| DOI: | 10.1007/s12325-024-02788-y |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s12325-024-02788-y Verlag, lizenzpflichtig, Volltext: https://www.webofscience.com/api/gateway?GWVersion=2&SrcAuth=DynamicDOIArticle&SrcApp=WOS&KeyAID=10.1007%2Fs12325-024-02788-y&DestApp=DOI&SrcAppSID=EUW1ED0B964qJQPXo78SFSFjS0JjC&SrcJTitle=ADVANCES+IN+THERAPY&DestDOIRegistrantName=Springer-Verlag 
|
| Author Notes: | Fritz H. Hengerer, Gerd U. Auffarth, Ina Conrad-Hengerer |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1890126365 | ||
| 003 | DE-627 | ||
| 005 | 20240703182553.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240528s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s12325-024-02788-y |2 doi | |
| 035 | |a (DE-627)1890126365 | ||
| 035 | |a (DE-599)KXP1890126365 | ||
| 035 | |a (OCoLC)1443679168 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Hengerer, Fritz |d 1970- |e VerfasserIn |0 (DE-588)12088142X |0 (DE-627)705060470 |0 (DE-576)292429053 |4 aut | |
| 245 | 1 | 0 | |a 7-year efficacy and safety of iStent inject trabecular micro-bypass in combined and standalone usage |c Fritz H. Hengerer, Gerd U. Auffarth, Ina Conrad-Hengerer |
| 246 | 3 | 3 | |a Seven-year efficacy and safety of iStent inject trabecular micro-bypass in combined and standalone usage |
| 264 | 1 | |c 16 February 2024 | |
| 300 | |b Illustrationen | ||
| 300 | |a 19 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 28.05.2024 | ||
| 500 | |a Im Titel ist "inject" schräg gestellt | ||
| 520 | |a Introduction: This study evaluated 7-year effectiveness and safety of second-generation trabecular micro-bypass implantation (iStent inject) either in combination with cataract surgery or as a standalone procedure (Combined or Standalone subgroups, respectively) in eyes with open-angle glaucoma. Methods: This prospective, non-randomized, unmasked, longitudinal study included 125 consecutive iStent inject cases of a single surgeon at a large German academic hospital. Patients had considerable preoperative disease burden, with mean intraocular pressure (IOP) of 23.5 mmHg, 84.8% of eyes on >= 2 medications, and 38.4% of eyes with prior glaucoma surgery. IOP, medications, adverse events, and secondary surgeries were assessed through 7 years in the Overall cohort and in Combined (n = 81) and Standalone (n = 44) subgroups. Results: Over 7-year follow-up, mean IOP decreased by 36.2-40.0% in Overall eyes, 34.1-38.9% in Combined eyes, and 39.5-43.5% in Standalone eyes (p < 0.001 at all timepoints for all groups). Meanwhile, mean medications decreased by 59.3-71.3% in Overall eyes, 57.9-69.0% in Combined eyes, and 62.1-76.2% in Standalone eyes (p < 0.001 at all timepoints in all groups). At last follow-up (mean 77.4 months; 92.8% of patients with last visit at 6 or 7 years), 83.7% of Overall eyes, 82.3% of Combined eyes, and 86.4% of Standalone eyes had achieved >= 20% IOP reduction vs preoperative. At last follow-up vs preoperative, 100% of eyes in all groups had the same or lower IOP and 100% had the same or lower medication regimen. Safety outcomes were favorable, with no filtration surgeries and only 4.84% of eyes experiencing clinically significant visual field loss over 7 years of follow-up. Conclusion: iStent inject implantation with or without phacoemulsification produced significant and durable 7-year reductions in IOP (similar to 34-44% reduction) and medications (similar to 58-76% reduction) while preventing filtering surgery in this cohort of patients with relatively high preoperative disease burden. Combined and Standalone cases had similarly favorable effectiveness and safety. | ||
| 650 | 4 | |a Cataract | |
| 650 | 4 | |a CATARACT-EXTRACTION | |
| 650 | 4 | |a Intraocular pressure | |
| 650 | 4 | |a INTRAOCULAR-PRESSURE | |
| 650 | 4 | |a iStent inject | |
| 650 | 4 | |a LENS IMPLANTATION | |
| 650 | 4 | |a Long-term | |
| 650 | 4 | |a MICROBYPASS STENT IMPLANTATION | |
| 650 | 4 | |a Microinvasive glaucoma surgery (MIGS) | |
| 650 | 4 | |a OPEN-ANGLE GLAUCOMA | |
| 650 | 4 | |a OUTCOMES | |
| 650 | 4 | |a PHACOEMULSIFICATION | |
| 650 | 4 | |a QUALITY-OF-LIFE | |
| 650 | 4 | |a REDUCTION | |
| 650 | 4 | |a Second-generation | |
| 650 | 4 | |a Stent | |
| 650 | 4 | |a Trabecular bypass | |
| 650 | 4 | |a TRIAL | |
| 700 | 1 | |a Auffarth, Gerd U. |d 1964- |e VerfasserIn |0 (DE-588)123385261 |0 (DE-627)577130420 |0 (DE-576)293687277 |4 aut | |
| 700 | 1 | |a Conrad-Hengerer, Ina |d 1973- |e VerfasserIn |0 (DE-588)1020458305 |0 (DE-627)691225273 |0 (DE-576)36048686X |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Advances in therapy |d Tarporley : Springer Healthcare Communications, 2000 |g 41(2024), 4, Seite 1462-1480 |h Online-Ressource |w (DE-627)563170433 |w (DE-600)2421646-X |w (DE-576)306836041 |x 1865-8652 |7 nnas |a 7-year efficacy and safety of iStent inject trabecular micro-bypass in combined and standalone usage |
| 773 | 1 | 8 | |g volume:41 |g year:2024 |g number:4 |g pages:1462-1480 |g extent:19 |a 7-year efficacy and safety of iStent inject trabecular micro-bypass in combined and standalone usage |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s12325-024-02788-y |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.webofscience.com/api/gateway?GWVersion=2&SrcAuth=DynamicDOIArticle&SrcApp=WOS&KeyAID=10.1007%2Fs12325-024-02788-y&DestApp=DOI&SrcAppSID=EUW1ED0B964qJQPXo78SFSFjS0JjC&SrcJTitle=ADVANCES+IN+THERAPY&DestDOIRegistrantName=Springer-Verlag |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20240528 | ||
| 993 | |a Article | ||
| 994 | |a 2024 | ||
| 998 | |g 1020458305 |a Conrad-Hengerer, Ina |m 1020458305:Conrad-Hengerer, Ina |d 910000 |d 910900 |d 50000 |e 910000PC1020458305 |e 910900PC1020458305 |e 50000PC1020458305 |k 0/910000/ |k 1/910000/910900/ |k 0/50000/ |p 3 |y j | ||
| 998 | |g 123385261 |a Auffarth, Gerd U. |m 123385261:Auffarth, Gerd U. |d 910000 |d 910900 |e 910000PA123385261 |e 910900PA123385261 |k 0/910000/ |k 1/910000/910900/ |p 2 | ||
| 998 | |g 12088142X |a Hengerer, Fritz |m 12088142X:Hengerer, Fritz |d 50000 |e 50000PH12088142X |k 0/50000/ |p 1 |x j | ||
| 999 | |a KXP-PPN1890126365 |e 4530616428 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"note":["Gesehen am 28.05.2024","Im Titel ist \"inject\" schräg gestellt"],"relHost":[{"pubHistory":["Nachgewiesen 17.2000 -"],"language":["eng"],"physDesc":[{"extent":"Online-Ressource"}],"recId":"563170433","disp":"7-year efficacy and safety of iStent inject trabecular micro-bypass in combined and standalone usageAdvances in therapy","title":[{"title":"Advances in therapy","title_sort":"Advances in therapy"}],"type":{"media":"Online-Ressource","bibl":"periodical"},"id":{"issn":["1865-8652"],"eki":["563170433"],"zdb":["2421646-X"]},"part":{"issue":"4","volume":"41","extent":"19","text":"41(2024), 4, Seite 1462-1480","year":"2024","pages":"1462-1480"},"origin":[{"dateIssuedDisp":"2000-","publisherPlace":"Tarporley","dateIssuedKey":"2000","publisher":"Springer Healthcare Communications"}]}],"physDesc":[{"noteIll":"Illustrationen","extent":"19 S."}],"recId":"1890126365","type":{"bibl":"article-journal","media":"Online-Ressource"},"titleAlt":[{"title":"Seven-year efficacy and safety of iStent inject trabecular micro-bypass in combined and standalone usage"}],"language":["eng"],"name":{"displayForm":["Fritz H. Hengerer, Gerd U. Auffarth, Ina Conrad-Hengerer"]},"title":[{"title":"7-year efficacy and safety of iStent inject trabecular micro-bypass in combined and standalone usage","title_sort":"7-year efficacy and safety of iStent inject trabecular micro-bypass in combined and standalone usage"}],"id":{"eki":["1890126365"],"doi":["10.1007/s12325-024-02788-y"]},"person":[{"given":"Fritz","family":"Hengerer","role":"aut","display":"Hengerer, Fritz"},{"family":"Auffarth","role":"aut","display":"Auffarth, Gerd U.","given":"Gerd U."},{"given":"Ina","role":"aut","display":"Conrad-Hengerer, Ina","family":"Conrad-Hengerer"}],"origin":[{"dateIssuedKey":"2024","dateIssuedDisp":"16 February 2024"}]} | ||
| SRT | |a HENGERERFR7YEAREFFIC1620 | ||