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BMI-adapted double low-dose dual-source aortic CT for endoleak detection after endovascular repair: a prospective intra-individual diagnostic accuracy study

Purpose: To assess the diagnostic accuracy of BMI-adapted, low-radiation and low-iodine dose, dual-source aortic CT for endoleak detection in non-obese and obese patients following endovascular aortic repair. Methods: In this prospective single-center study, patients referred for follow-up CT after...

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Main Authors: Melzig, Claudius (Author) , Hartmann, Sibylle (Author) , Steuwe, Andrea (Author) , Egger, Jan (Author) , Do, Thuy (Author) , Geisbüsch, Philipp (Author) , Kauczor, Hans-Ulrich (Author) , Rengier, Fabian (Author) , Fink, Matthias A. (Author)
Format: Article (Journal)
Language:English
Published: 27 January 2024
In: Diagnostics
Year: 2024, Volume: 14, Issue: 3, Pages: 1-12
ISSN:2075-4418
DOI:10.3390/diagnostics14030280
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.3390/diagnostics14030280
Verlag, kostenfrei, Volltext: https://www.mdpi.com/2075-4418/14/3/280
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Author Notes:Claudius Melzig, Sibylle Hartmann, Andrea Steuwe, Jan Egger, Thuy D. Do, Philipp Geisbüsch, Hans-Ulrich Kauczor, Fabian Rengier and Matthias A. Fink
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Summary:Purpose: To assess the diagnostic accuracy of BMI-adapted, low-radiation and low-iodine dose, dual-source aortic CT for endoleak detection in non-obese and obese patients following endovascular aortic repair. Methods: In this prospective single-center study, patients referred for follow-up CT after endovascular repair with a history of at least one standard triphasic (native, arterial and delayed phase) routine CT protocol were enrolled. Patients were divided into two groups and allocated to a BMI-adapted (group A, BMI < 30 kg/m2; group B, BMI ≥ 30 kg/m2) double low-dose CT (DLCT) protocol comprising single-energy arterial and dual-energy delayed phase series with virtual non-contrast (VNC) reconstructions. An in-patient comparison of the DLCT and routine CT protocol as reference standard was performed regarding differences in diagnostic accuracy, radiation dose, and image quality. Results: Seventy-five patients were included in the study (mean age 73 ± 8 years, 63 (84%) male). Endoleaks were diagnosed in 20 (26.7%) patients, 11 of 53 (20.8%) in group A and 9 of 22 (40.9%) in group B. Two radiologists achieved an overall diagnostic accuracy of 98.7% and 97.3% for endoleak detection, with 100% in group A and 95.5% and 90.9% in group B. All examinations were diagnostic. The DLCT protocol reduced the effective dose from 10.0 ± 3.6 mSv to 6.1 ± 1.5 mSv (p < 0.001) and the total iodine dose from 31.5 g to 14.5 g in group A and to 17.4 g in group B. Conclusion: Optimized double low-dose dual-source aortic CT with VNC, arterial and delayed phase images demonstrated high diagnostic accuracy for endoleak detection and significant radiation and iodine dose reductions in both obese and non-obese patients compared to the reference standard of triple phase, standard radiation and iodine dose aortic CT.
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Gesehen am 10.06.2024
Physical Description:Online Resource
ISSN:2075-4418
DOI:10.3390/diagnostics14030280

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