Utility of bioelectrical phase angle for cardiovascular risk assessment among individuals with and without diabetes mellitus
Purpose - Low values of bioimpedance-derived phase angle (PA) have been associated with various adverse outcomes. We investigated the association of PA with cardiovascular markers in individuals with and without diabetes mellitus (DM). - Methods - PA was measured in 452 adults (without DM n = 153, T...
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| Auteurs principaux: | , , , , , , , |
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| Format: | Article (Journal) |
| Langue: | anglais |
| Publié: |
January-February 2024
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| In: |
Diabetes & vascular disease research
Year: 2024, Volume: 21, Numéro: 1, Pages: 1-10 |
| ISSN: | 1752-8984 |
| DOI: | 10.1177/14791641231223701 |
| Accès en ligne: | Verlag, kostenfrei, Volltext: https://doi.org/10.1177/14791641231223701
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| Notes sur l'auteur: | Dimitrios Tsilingiris, Lukas Schimpfle, Zoltan Κender, Alba Sulaj, Ekaterina von Rauchhaupt, Stephan Herzig, Julia Szendroedi, and Stefan Kopf |
| Résumé: | Purpose - Low values of bioimpedance-derived phase angle (PA) have been associated with various adverse outcomes. We investigated the association of PA with cardiovascular markers in individuals with and without diabetes mellitus (DM). - Methods - PA was measured in 452 adults (without DM n = 153, T1DM n = 67, T2DM n = 232). Carotid intima-media thickness (IMT), renal resistive index (RRI), ankle-brachial index (ABI) and carotid-femoral Pulse Wave Velocity (cfPWV) were estimated. Furthermore, the levels of high-sensitive Troponin-T [hsTnT], N-terminal brain natriuretic peptide [NT-pro-BNP]) were measured. - Results - PA values were lower in DM independently of age, gender, and BMI (estimated marginal means 6.21, 5.83, 5.95 for controls, T1DM, T2DM p < .05), a finding which persisted after propensity score matching. PA correlated negatively with IMT (r = −0.181), RRI (r = −0.374), cfPWV (r = −0.358), hsTnT (r = −0.238) and NT-pro-BNP (r = −0.318) (all p < .001). In multivariable analysis, the associations with RRI, cfPWV, hsTnT and NT-pro-BNP remained unchanged. PA values 6.0-6.5° for males and 5.2-5.8° for females were predictive of commonly used cutoffs. The combination of ΑCC/AHA ASCVD Score with PA outperformed either factor in predicting cfPWV, RRI for males and hsTnT, BNP for both genders. - Conclusions - PA exhibits independent correlations with various parameters pertinent to cardiovascular risk and may be useful for cardiovascular assessment. |
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| Description: | Vorab online veröffentlicht: 2. Februar 2024 Gesehen am 10.06.2024 |
| Description matérielle: | Online Resource |
| ISSN: | 1752-8984 |
| DOI: | 10.1177/14791641231223701 |