Frequency and prognostic value of circulating tumor cells in cancer of unknown primary
Cancer of unknown primary (CUP) is defined as a primary metastatic malignancy, in which the primary tumor remains elusive in spite of a comprehensive diagnostic workup. The frequency and prognostic value of circulating tumor cells (CTCs), which are considered to be the source of metastasis, has not...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
January 2024
|
| In: |
Clinical chemistry
Year: 2024, Volume: 70, Issue: 1, Pages: 297-306 |
| ISSN: | 1530-8561 |
| DOI: | 10.1093/clinchem/hvad180 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1093/clinchem/hvad180
|
| Author Notes: | Maria Pouyiourou, Tilmann Bochtler, Cornelia Coith, Harriet Wikman, Bianca Kraft, Thomas Hielscher, Albrecht Stenzinger, Sabine Riethdorf, Klaus Pantel, and Alwin Krämer |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1890982415 | ||
| 003 | DE-627 | ||
| 005 | 20241205141540.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240610s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1093/clinchem/hvad180 |2 doi | |
| 035 | |a (DE-627)1890982415 | ||
| 035 | |a (DE-599)KXP1890982415 | ||
| 035 | |a (OCoLC)1475297918 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Pouyiourou, Maria |e VerfasserIn |0 (DE-588)1245540866 |0 (DE-627)1777245079 |4 aut | |
| 245 | 1 | 0 | |a Frequency and prognostic value of circulating tumor cells in cancer of unknown primary |c Maria Pouyiourou, Tilmann Bochtler, Cornelia Coith, Harriet Wikman, Bianca Kraft, Thomas Hielscher, Albrecht Stenzinger, Sabine Riethdorf, Klaus Pantel, and Alwin Krämer |
| 264 | 1 | |c January 2024 | |
| 300 | |b Illustrationen | ||
| 300 | |a 10 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Veröffentlicht: 4. Januar 2024 | ||
| 500 | |a Gesehen am 10.06.2024 | ||
| 520 | |a Cancer of unknown primary (CUP) is defined as a primary metastatic malignancy, in which the primary tumor remains elusive in spite of a comprehensive diagnostic workup. The frequency and prognostic value of circulating tumor cells (CTCs), which are considered to be the source of metastasis, has not yet been systematically evaluated in CUP.A total of 110 patients with a confirmed diagnosis of CUP according to the European Society for Medical Oncology (ESMO) guidelines, who presented to our clinic between July 2021 and May 2023, provided blood samples for CTC quantification using CellSearch methodology. CTC counts were correlated with demographic, clinical, and molecular data generated by comprehensive genomic profiling of tumor tissue.CTCs were detected in 26% of all patients at initial presentation to our department. The highest CTC frequency was observed among patients with unfavorable CUP (35.5%), while patients with single-site/oligometastatic CUP harbored the lowest CTC frequency (11.4%). No statistically significant association between CTC positivity and the number of affected organs (P = 0.478) or disease burden (P = 0.120) was found. High CTC levels (≥5 CTCs/7.5 mL; 12/95 analyzed patients) predicted for adverse overall survival compared to negative or low CTC counts (6-months overall survival rate 90% vs 32%, log-rank P < 0.001; HR 5.43; 95% CI 2.23-13.2). CTC dynamics were also prognostic for overall survival by landmark analysis (log-rank P < 0.001, HR 10.2, 95% CI 1.95-52.9).CTC frequency is a strong, independent predictor of survival in patients with CUP. CTC quantification provides a useful prognostic tool in the management of these patients. | ||
| 700 | 1 | |a Bochtler, Tilmann |d 1975- |e VerfasserIn |0 (DE-588)128398957 |0 (DE-627)372639925 |0 (DE-576)187323909 |4 aut | |
| 700 | 1 | |a Coith, Cornelia |e VerfasserIn |4 aut | |
| 700 | 1 | |a Wikman, Harriet |e VerfasserIn |0 (DE-588)1027791387 |0 (DE-627)729736636 |0 (DE-576)375320202 |4 aut | |
| 700 | 1 | |a Kraft, Bianca |d 1981- |e VerfasserIn |0 (DE-588)1011974614 |0 (DE-627)660882612 |0 (DE-576)344709175 |4 aut | |
| 700 | 1 | |a Hielscher, Thomas |e VerfasserIn |0 (DE-588)1159594791 |0 (DE-627)1022977768 |0 (DE-576)50506068X |4 aut | |
| 700 | 1 | |a Stenzinger, Albrecht |e VerfasserIn |0 (DE-588)139606106 |0 (DE-627)703395238 |0 (DE-576)312432755 |4 aut | |
| 700 | 1 | |a Riethdorf, Sabine |e VerfasserIn |0 (DE-588)1027790399 |0 (DE-627)729735001 |0 (DE-576)375318909 |4 aut | |
| 700 | 1 | |a Pantel, Klaus |d 1960- |e VerfasserIn |0 (DE-588)1027683606 |0 (DE-627)729554929 |0 (DE-576)373549997 |4 aut | |
| 700 | 1 | |a Krämer, Alwin |e VerfasserIn |0 (DE-588)1067780025 |0 (DE-627)819183431 |0 (DE-576)426900820 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Clinical chemistry |d Washington, DC : American Association for Clinical Chemistry, 1955 |g 70(2024), 1 vom: Jan., Seite 297-306 |h Online-Ressource |w (DE-627)266883117 |w (DE-600)1468161-4 |w (DE-576)075146401 |x 1530-8561 |7 nnas |a Frequency and prognostic value of circulating tumor cells in cancer of unknown primary |
| 773 | 1 | 8 | |g volume:70 |g year:2024 |g number:1 |g month:01 |g pages:297-306 |g extent:10 |a Frequency and prognostic value of circulating tumor cells in cancer of unknown primary |
| 856 | 4 | 0 | |u https://doi.org/10.1093/clinchem/hvad180 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20240610 | ||
| 993 | |a Article | ||
| 994 | |a 2024 | ||
| 998 | |g 1067780025 |a Krämer, Alwin |m 1067780025:Krämer, Alwin |d 910000 |d 910100 |e 910000PK1067780025 |e 910100PK1067780025 |k 0/910000/ |k 1/910000/910100/ |p 10 |y j | ||
| 998 | |g 139606106 |a Stenzinger, Albrecht |m 139606106:Stenzinger, Albrecht |d 910000 |d 912000 |e 910000PS139606106 |e 912000PS139606106 |k 0/910000/ |k 1/910000/912000/ |p 7 | ||
| 998 | |g 1159594791 |a Hielscher, Thomas |m 1159594791:Hielscher, Thomas |d 50000 |e 50000PH1159594791 |k 0/50000/ |p 6 | ||
| 998 | |g 1011974614 |a Kraft, Bianca |m 1011974614:Kraft, Bianca |d 910000 |d 910100 |e 910000PK1011974614 |e 910100PK1011974614 |k 0/910000/ |k 1/910000/910100/ |p 5 | ||
| 998 | |g 128398957 |a Bochtler, Tilmann |m 128398957:Bochtler, Tilmann |d 910000 |d 910100 |d 50000 |e 910000PB128398957 |e 910100PB128398957 |e 50000PB128398957 |k 0/910000/ |k 1/910000/910100/ |k 0/50000/ |p 2 | ||
| 998 | |g 1245540866 |a Pouyiourou, Maria |m 1245540866:Pouyiourou, Maria |d 910000 |d 910100 |e 910000PP1245540866 |e 910100PP1245540866 |k 0/910000/ |k 1/910000/910100/ |p 1 |x j | ||
| 999 | |a KXP-PPN1890982415 |e 453601537X | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"origin":[{"dateIssuedKey":"2024","dateIssuedDisp":"January 2024"}],"relHost":[{"note":["Gesehen am 26.08.2021"],"pubHistory":["1.1955 -"],"language":["eng"],"part":{"issue":"1","extent":"10","pages":"297-306","text":"70(2024), 1 vom: Jan., Seite 297-306","volume":"70","year":"2024"},"corporate":[{"display":"American Association of Clinical Chemists","role":"isb"}],"type":{"bibl":"periodical","media":"Online-Ressource"},"disp":"Frequency and prognostic value of circulating tumor cells in cancer of unknown primaryClinical chemistry","recId":"266883117","origin":[{"dateIssuedKey":"1955","publisherPlace":"Washington, DC ; Oxford","publisher":"American Association for Clinical Chemistry ; Oxford University Press","dateIssuedDisp":"1955-"}],"title":[{"title_sort":"Clinical chemistry","subtitle":"journal of the American Association for Clinical Chemistry ; international journal of laboratory medicine and molecular diagnostics","title":"Clinical chemistry"}],"id":{"zdb":["1468161-4"],"eki":["266883117"],"issn":["1530-8561"]},"physDesc":[{"extent":"Online-Ressource"}]}],"id":{"doi":["10.1093/clinchem/hvad180"],"eki":["1890982415"]},"physDesc":[{"extent":"10 S.","noteIll":"Illustrationen"}],"title":[{"title":"Frequency and prognostic value of circulating tumor cells in cancer of unknown primary","title_sort":"Frequency and prognostic value of circulating tumor cells in cancer of unknown primary"}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"note":["Veröffentlicht: 4. Januar 2024","Gesehen am 10.06.2024"],"person":[{"display":"Pouyiourou, Maria","given":"Maria","role":"aut","family":"Pouyiourou"},{"family":"Bochtler","role":"aut","given":"Tilmann","display":"Bochtler, Tilmann"},{"role":"aut","family":"Coith","display":"Coith, Cornelia","given":"Cornelia"},{"display":"Wikman, Harriet","given":"Harriet","family":"Wikman","role":"aut"},{"role":"aut","family":"Kraft","given":"Bianca","display":"Kraft, Bianca"},{"given":"Thomas","display":"Hielscher, Thomas","role":"aut","family":"Hielscher"},{"display":"Stenzinger, Albrecht","given":"Albrecht","role":"aut","family":"Stenzinger"},{"role":"aut","family":"Riethdorf","given":"Sabine","display":"Riethdorf, Sabine"},{"given":"Klaus","display":"Pantel, Klaus","family":"Pantel","role":"aut"},{"given":"Alwin","display":"Krämer, Alwin","family":"Krämer","role":"aut"}],"recId":"1890982415","language":["eng"],"name":{"displayForm":["Maria Pouyiourou, Tilmann Bochtler, Cornelia Coith, Harriet Wikman, Bianca Kraft, Thomas Hielscher, Albrecht Stenzinger, Sabine Riethdorf, Klaus Pantel, and Alwin Krämer"]}} | ||
| SRT | |a POUYIOUROUFREQUENCYA2024 | ||