Glutarate tunes T cell fate
In this issue of Nature Metabolism, a study shows that glutarate increases memory T cells as well as T cell cytotoxicity and reduces tumour growth. During T cell activation, glutarate levels and glutarylation increase. Glutarate inhibits α-ketoglutarate-dependent dioxygenases, and glutarylation redu...
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| Hauptverfasser: | , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
21 August 2023
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| In: |
Nature metabolism
Year: 2023, Jahrgang: 5, Heft: 10, Pages: 1649-1651 |
| ISSN: | 2522-5812 |
| DOI: | 10.1038/s42255-023-00878-9 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/s42255-023-00878-9 Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/s42255-023-00878-9 
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| Verfasserangaben: | Francisco Yanqui-Rivera & Christiane A. Opitz |
| Zusammenfassung: | In this issue of Nature Metabolism, a study shows that glutarate increases memory T cells as well as T cell cytotoxicity and reduces tumour growth. During T cell activation, glutarate levels and glutarylation increase. Glutarate inhibits α-ketoglutarate-dependent dioxygenases, and glutarylation reduces pyruvate dehydrogenase complex activity and enhances glycolysis. |
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| Beschreibung: | Gesehen am 10.06.2024 |
| Beschreibung: | Online Resource |
| ISSN: | 2522-5812 |
| DOI: | 10.1038/s42255-023-00878-9 |