Repeat surgery of recurrent glioma for molecularly informed treatment in the age of precision oncology: a risk-benefit analysis
Purpose: Surgery for recurrent glioma provides cytoreduction and tissue for molecularly informed treatment. With mostly heavily pretreated patients involved, it is unclear whether the benefits of repeat surgery outweigh its potential risks. Methods: Patients receiving surgery for recurrent glioma WH...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
09 February 2024
|
| In: |
Journal of neuro-oncology
Year: 2024, Jahrgang: 167, Heft: 2, Pages: 245-255 |
| ISSN: | 1573-7373 |
| DOI: | 10.1007/s11060-024-04595-5 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1007/s11060-024-04595-5
|
| Verfasserangaben: | Obada T. Alhalabi, Philip Dao Trong, Manuel Kaes, Martin Jakobs, Tobias Kessler, Hannah Oehler, Laila König, Tanja Eichkorn, Felix Sahm, Jürgen Debus, Andreas von Deimling, Wolfgang Wick, Antje Wick, Sandro M. Krieg, Andreas W. Unterberg, Christine Jungk |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1891061798 | ||
| 003 | DE-627 | ||
| 005 | 20250327135625.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240611s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s11060-024-04595-5 |2 doi | |
| 035 | |a (DE-627)1891061798 | ||
| 035 | |a (DE-599)KXP1891061798 | ||
| 035 | |a (OCoLC)1475299490 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Alhalabi, Obada |d 1994- |e VerfasserIn |0 (DE-588)1193522706 |0 (DE-627)167225941X |4 aut | |
| 245 | 1 | 0 | |a Repeat surgery of recurrent glioma for molecularly informed treatment in the age of precision oncology |b a risk-benefit analysis |c Obada T. Alhalabi, Philip Dao Trong, Manuel Kaes, Martin Jakobs, Tobias Kessler, Hannah Oehler, Laila König, Tanja Eichkorn, Felix Sahm, Jürgen Debus, Andreas von Deimling, Wolfgang Wick, Antje Wick, Sandro M. Krieg, Andreas W. Unterberg, Christine Jungk |
| 264 | 1 | |c 09 February 2024 | |
| 300 | |b Illustrationen | ||
| 300 | |a 11 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Online veröffentlicht: 09. Februar 2024 | ||
| 500 | |a Gesehen am 11.06.2024 | ||
| 520 | |a Purpose: Surgery for recurrent glioma provides cytoreduction and tissue for molecularly informed treatment. With mostly heavily pretreated patients involved, it is unclear whether the benefits of repeat surgery outweigh its potential risks. Methods: Patients receiving surgery for recurrent glioma WHO grade 2–4 with the goal of tissue sampling for targeted therapies were analyzed retrospectively. Complication rates (surgical, neurological) were compared to our institutional glioma surgery cohort. Tissue molecular diagnostic yield, targeted therapies and post-surgical survival rates were analyzed. Results: Between 2017 and 2022, tumor board recommendation for targeted therapy through molecular diagnostics was made for 180 patients. Of these, 70 patients (38%) underwent repeat surgery. IDH-wildtype glioblastoma was diagnosed in 48 patients (69%), followed by IDH-mutant astrocytoma (n = 13; 19%) and oligodendroglioma (n = 9; 13%). Gross total resection (GTR) was achieved in 50 patients (71%). Tissue was processed for next-generation sequencing in 64 cases (91%), and for DNA methylation analysis in 58 cases (83%), while immunohistochemistry for mTOR phosphorylation was performed in 24 cases (34%). Targeted therapy was recommended in 35 (50%) and commenced in 21 (30%) cases. Postoperatively, 7 patients (11%) required revision surgery, compared to 7% (p = 0.519) and 6% (p = 0.359) of our reference cohorts of patients undergoing first and second craniotomy, respectively. Non-resolving neurological deterioration was documented in 6 cases (10% vs. 8%, p = 0.612, after first and 4%, p = 0.519, after second craniotomy). Median survival after repeat surgery was 399 days in all patients and 348 days in GBM patients after repeat GTR. Conclusion: Surgery for recurrent glioma provides relevant molecular diagnostic information with a direct consequence for targeted therapy under a reasonable risk of postoperative complications. With satisfactory postoperative survival it can therefore complement a multi-modal glioma therapy approach. | ||
| 650 | 4 | |a Molecular diagnostics | |
| 650 | 4 | |a Precision oncology | |
| 650 | 4 | |a Recurrent glioma | |
| 650 | 4 | |a Surgical complications | |
| 650 | 4 | |a Targeted therapy | |
| 700 | 1 | |a Dao Trong, Huy Philip |d 1985- |e VerfasserIn |0 (DE-588)1029750092 |0 (DE-627)734006942 |0 (DE-576)377597031 |4 aut | |
| 700 | 1 | |a Kaes, Manuel |e VerfasserIn |0 (DE-588)1332663176 |0 (DE-627)1891067206 |4 aut | |
| 700 | 1 | |a Jakobs, Martin |d 1985- |e VerfasserIn |0 (DE-588)1050384962 |0 (DE-627)78392092X |0 (DE-576)404578756 |4 aut | |
| 700 | 1 | |a Keßler, Tobias |d 1987- |e VerfasserIn |0 (DE-588)1104151693 |0 (DE-627)86164591X |0 (DE-576)470840277 |4 aut | |
| 700 | 1 | |a Oehler, Hannah |d 1991- |e VerfasserIn |0 (DE-588)1172689466 |0 (DE-627)1041323468 |0 (DE-576)514754907 |4 aut | |
| 700 | 1 | |a König, Laila |d 1986- |e VerfasserIn |0 (DE-588)1053640579 |0 (DE-627)790403315 |0 (DE-576)409584282 |4 aut | |
| 700 | 1 | |a Eichkorn, Tanja |e VerfasserIn |0 (DE-588)1191801187 |0 (DE-627)167027666X |4 aut | |
| 700 | 1 | |a Sahm, Felix |d 1984- |e VerfasserIn |0 (DE-588)1022852132 |0 (DE-627)717318478 |0 (DE-576)366075020 |4 aut | |
| 700 | 1 | |a Debus, Jürgen |d 1964- |e VerfasserIn |0 (DE-588)1022671421 |0 (DE-627)717025780 |0 (DE-576)365774944 |4 aut | |
| 700 | 1 | |a Deimling, Andreas von |d 1959- |e VerfasserIn |0 (DE-588)103034115X |0 (DE-627)735093946 |0 (DE-576)378138065 |4 aut | |
| 700 | 1 | |a Wick, Wolfgang |d 1970- |e VerfasserIn |0 (DE-588)120297736 |0 (DE-627)080586929 |0 (DE-576)186221320 |4 aut | |
| 700 | 1 | |a Wick, Antje |d 1972- |e VerfasserIn |0 (DE-588)122759869 |0 (DE-627)706032101 |0 (DE-576)293409609 |4 aut | |
| 700 | 1 | |a Krieg, Sandro |d 1982- |e VerfasserIn |0 (DE-588)14001649X |0 (DE-627)703539132 |0 (DE-576)314196935 |4 aut | |
| 700 | 1 | |a Unterberg, Andreas |e VerfasserIn |0 (DE-588)1032681187 |0 (DE-627)738641200 |0 (DE-576)168441233 |4 aut | |
| 700 | 1 | |a Jungk, Christine |e VerfasserIn |0 (DE-588)1051888247 |0 (DE-627)78696765X |0 (DE-576)407515968 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of neuro-oncology |d Dordrecht [u.a.] : Springer Science + Business Media B.V, 1983 |g 167(2024), 2 vom: Apr., Seite 245-255 |h Online-Ressource |w (DE-627)32046122X |w (DE-600)2007293-4 |w (DE-576)107058944 |x 1573-7373 |7 nnas |a Repeat surgery of recurrent glioma for molecularly informed treatment in the age of precision oncology a risk-benefit analysis |
| 773 | 1 | 8 | |g volume:167 |g year:2024 |g number:2 |g month:04 |g pages:245-255 |g extent:11 |a Repeat surgery of recurrent glioma for molecularly informed treatment in the age of precision oncology a risk-benefit analysis |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s11060-024-04595-5 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20240611 | ||
| 993 | |a Article | ||
| 994 | |a 2024 | ||
| 998 | |g 1051888247 |a Jungk, Christine |m 1051888247:Jungk, Christine |d 910000 |d 911200 |d 50000 |e 910000PJ1051888247 |e 911200PJ1051888247 |e 50000PJ1051888247 |k 0/910000/ |k 1/910000/911200/ |k 0/50000/ |p 16 |y j | ||
| 998 | |g 1032681187 |a Unterberg, Andreas |m 1032681187:Unterberg, Andreas |d 910000 |d 911200 |e 910000PU1032681187 |e 911200PU1032681187 |k 0/910000/ |k 1/910000/911200/ |p 15 | ||
| 998 | |g 14001649X |a Krieg, Sandro |m 14001649X:Krieg, Sandro |d 910000 |d 911200 |e 910000PK14001649X |e 911200PK14001649X |k 0/910000/ |k 1/910000/911200/ |p 14 | ||
| 998 | |g 122759869 |a Wick, Antje |m 122759869:Wick, Antje |d 910000 |d 911100 |d 50000 |e 910000PW122759869 |e 911100PW122759869 |e 50000PW122759869 |k 0/910000/ |k 1/910000/911100/ |k 0/50000/ |p 13 | ||
| 998 | |g 120297736 |a Wick, Wolfgang |m 120297736:Wick, Wolfgang |d 910000 |d 911100 |e 910000PW120297736 |e 911100PW120297736 |k 0/910000/ |k 1/910000/911100/ |p 12 | ||
| 998 | |g 103034115X |a Deimling, Andreas von |m 103034115X:Deimling, Andreas von |d 910000 |d 912000 |e 910000PD103034115X |e 912000PD103034115X |k 0/910000/ |k 1/910000/912000/ |p 11 | ||
| 998 | |g 1022671421 |a Debus, Jürgen |m 1022671421:Debus, Jürgen |d 910000 |d 911400 |e 910000PD1022671421 |e 911400PD1022671421 |k 0/910000/ |k 1/910000/911400/ |p 10 | ||
| 998 | |g 1022852132 |a Sahm, Felix |m 1022852132:Sahm, Felix |d 910000 |d 912000 |d 50000 |e 910000PS1022852132 |e 912000PS1022852132 |e 50000PS1022852132 |k 0/910000/ |k 1/910000/912000/ |k 0/50000/ |p 9 | ||
| 998 | |g 1191801187 |a Eichkorn, Tanja |m 1191801187:Eichkorn, Tanja |d 910000 |d 911400 |e 910000PE1191801187 |e 911400PE1191801187 |k 0/910000/ |k 1/910000/911400/ |p 8 | ||
| 998 | |g 1053640579 |a König, Laila |m 1053640579:König, Laila |d 910000 |d 911400 |e 910000PK1053640579 |e 911400PK1053640579 |k 0/910000/ |k 1/910000/911400/ |p 7 | ||
| 998 | |g 1172689466 |a Oehler, Hannah |m 1172689466:Oehler, Hannah |d 910000 |d 911100 |e 910000PO1172689466 |e 911100PO1172689466 |k 0/910000/ |k 1/910000/911100/ |p 6 | ||
| 998 | |g 1104151693 |a Keßler, Tobias |m 1104151693:Keßler, Tobias |d 910000 |d 911100 |e 910000PK1104151693 |e 911100PK1104151693 |k 0/910000/ |k 1/910000/911100/ |p 5 | ||
| 998 | |g 1050384962 |a Jakobs, Martin |m 1050384962:Jakobs, Martin |d 910000 |d 911200 |d 50000 |e 910000PJ1050384962 |e 911200PJ1050384962 |e 50000PJ1050384962 |k 0/910000/ |k 1/910000/911200/ |k 0/50000/ |p 4 | ||
| 998 | |g 1332663176 |a Kaes, Manuel |m 1332663176:Kaes, Manuel |d 910000 |d 911200 |e 910000PK1332663176 |e 911200PK1332663176 |k 0/910000/ |k 1/910000/911200/ |p 3 | ||
| 998 | |g 1029750092 |a Dao Trong, Huy Philip |m 1029750092:Dao Trong, Huy Philip |d 910000 |d 911200 |e 910000PD1029750092 |e 911200PD1029750092 |k 0/910000/ |k 1/910000/911200/ |p 2 | ||
| 998 | |g 1193522706 |a Alhalabi, Obada |m 1193522706:Alhalabi, Obada |d 910000 |d 911200 |e 910000PA1193522706 |e 911200PA1193522706 |k 0/910000/ |k 1/910000/911200/ |p 1 |x j | ||
| 999 | |a KXP-PPN1891061798 |e 4536314210 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"name":{"displayForm":["Obada T. Alhalabi, Philip Dao Trong, Manuel Kaes, Martin Jakobs, Tobias Kessler, Hannah Oehler, Laila König, Tanja Eichkorn, Felix Sahm, Jürgen Debus, Andreas von Deimling, Wolfgang Wick, Antje Wick, Sandro M. Krieg, Andreas W. Unterberg, Christine Jungk"]},"id":{"eki":["1891061798"],"doi":["10.1007/s11060-024-04595-5"]},"physDesc":[{"noteIll":"Illustrationen","extent":"11 S."}],"recId":"1891061798","person":[{"role":"aut","given":"Obada","family":"Alhalabi","display":"Alhalabi, Obada"},{"display":"Dao Trong, Huy Philip","role":"aut","given":"Huy Philip","family":"Dao Trong"},{"display":"Kaes, Manuel","role":"aut","given":"Manuel","family":"Kaes"},{"role":"aut","given":"Martin","family":"Jakobs","display":"Jakobs, Martin"},{"display":"Keßler, Tobias","family":"Keßler","given":"Tobias","role":"aut"},{"display":"Oehler, Hannah","family":"Oehler","role":"aut","given":"Hannah"},{"display":"König, Laila","given":"Laila","role":"aut","family":"König"},{"given":"Tanja","role":"aut","family":"Eichkorn","display":"Eichkorn, Tanja"},{"given":"Felix","role":"aut","family":"Sahm","display":"Sahm, Felix"},{"display":"Debus, Jürgen","role":"aut","given":"Jürgen","family":"Debus"},{"given":"Andreas von","role":"aut","family":"Deimling","display":"Deimling, Andreas von"},{"role":"aut","given":"Wolfgang","family":"Wick","display":"Wick, Wolfgang"},{"given":"Antje","role":"aut","family":"Wick","display":"Wick, Antje"},{"display":"Krieg, Sandro","role":"aut","given":"Sandro","family":"Krieg"},{"family":"Unterberg","role":"aut","given":"Andreas","display":"Unterberg, Andreas"},{"display":"Jungk, Christine","family":"Jungk","role":"aut","given":"Christine"}],"relHost":[{"id":{"eki":["32046122X"],"issn":["1573-7373"],"zdb":["2007293-4"]},"title":[{"title_sort":"Journal of neuro-oncology","title":"Journal of neuro-oncology"}],"part":{"extent":"11","text":"167(2024), 2 vom: Apr., Seite 245-255","issue":"2","pages":"245-255","volume":"167","year":"2024"},"language":["eng"],"type":{"media":"Online-Ressource","bibl":"periodical"},"note":["Gesehen am 11.06.2018","Fortsetzung der Druck-Ausgabe"],"origin":[{"publisher":"Springer Science + Business Media B.V ; Kluwer","publisherPlace":"Dordrecht [u.a.] ; Dordrecht [u.a.]","dateIssuedKey":"1983","dateIssuedDisp":"1983-"}],"pubHistory":["1.1983 -"],"disp":"Repeat surgery of recurrent glioma for molecularly informed treatment in the age of precision oncology a risk-benefit analysisJournal of neuro-oncology","recId":"32046122X","physDesc":[{"extent":"Online-Ressource"}]}],"origin":[{"dateIssuedKey":"2024","dateIssuedDisp":"09 February 2024"}],"note":["Online veröffentlicht: 09. Februar 2024","Gesehen am 11.06.2024"],"language":["eng"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"title":[{"subtitle":"a risk-benefit analysis","title_sort":"Repeat surgery of recurrent glioma for molecularly informed treatment in the age of precision oncology","title":"Repeat surgery of recurrent glioma for molecularly informed treatment in the age of precision oncology"}]} | ||
| SRT | |a ALHALABIOBREPEATSURG0920 | ||