Phenotyping of COPD with MRI in comparison to same-day CT in a multi-centre trial
Objectives: A prospective, multi-centre study to evaluate concordance of morphologic lung MRI and CT in chronic obstructive pulmonary disease (COPD) phenotyping for airway disease and emphysema. Methods: A total of 601 participants with COPD from 15 sites underwent same-day morpho-functional chest M...
Saved in:
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
12 February 2024
|
| In: |
European radiology
Year: 2024, Volume: 34, Issue: 9, Pages: 5597-5609 |
| ISSN: | 1432-1084 |
| DOI: | 10.1007/s00330-024-10610-0 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.1007/s00330-024-10610-0
|
| Author Notes: | Sebastian Nauck, Moritz Pohl, Bertram J. Jobst, Claudius Melzig, Hagen Meredig, Oliver Weinheimer, Simon Triphan, Oyunbileg von Stackelberg, Philip Konietzke, Hans-Ulrich Kauczor, Claus P. Heußel, Mark O. Wielpütz, Jürgen Biederer and on behalf of the COSYCONET Study Group |
MARC
| LEADER | 00000caa a22000002c 4500 | ||
|---|---|---|---|
| 001 | 1891107089 | ||
| 003 | DE-627 | ||
| 005 | 20241205141856.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240612s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s00330-024-10610-0 |2 doi | |
| 035 | |a (DE-627)1891107089 | ||
| 035 | |a (DE-599)KXP1891107089 | ||
| 035 | |a (OCoLC)1475298221 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Nauck, Sebastian |e VerfasserIn |0 (DE-588)120158163X |0 (DE-627)1685480691 |4 aut | |
| 245 | 1 | 0 | |a Phenotyping of COPD with MRI in comparison to same-day CT in a multi-centre trial |c Sebastian Nauck, Moritz Pohl, Bertram J. Jobst, Claudius Melzig, Hagen Meredig, Oliver Weinheimer, Simon Triphan, Oyunbileg von Stackelberg, Philip Konietzke, Hans-Ulrich Kauczor, Claus P. Heußel, Mark O. Wielpütz, Jürgen Biederer and on behalf of the COSYCONET Study Group |
| 264 | 1 | |c 12 February 2024 | |
| 300 | |b Illustrationen | ||
| 300 | |a 13 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 12.06.2024 | ||
| 520 | |a Objectives: A prospective, multi-centre study to evaluate concordance of morphologic lung MRI and CT in chronic obstructive pulmonary disease (COPD) phenotyping for airway disease and emphysema. Methods: A total of 601 participants with COPD from 15 sites underwent same-day morpho-functional chest MRI and paired inspiratory-expiratory CT. Two readers systematically scored bronchial wall thickening, bronchiectasis, centrilobular nodules, air trapping and lung parenchyma defects in each lung lobe and determined COPD phenotype. A third reader acted as adjudicator to establish consensus. Inter-modality and inter-reader agreement were assessed using Cohen’s kappa (im-κ and ir-κ). Results: The mean combined MRI score for bronchiectasis/bronchial wall thickening was 4.5/12 (CT scores, 2.2/12 for bronchiectasis and 6/12 for bronchial wall thickening; im-κ, 0.04–0.3). Expiratory right/left bronchial collapse was observed in 51 and 47/583 on MRI (62 and 57/599 on CT; im-κ, 0.49–0.52). Markers of small airways disease on MRI were 0.15/12 for centrilobular nodules (CT, 0.34/12), 0.94/12 for air trapping (CT, 0.9/12) and 7.6/12 for perfusion deficits (CT, 0.37/12 for mosaic attenuation; im-κ, 0.1–0.41). The mean lung defect score on MRI was 1.3/12 (CT emphysema score, 5.8/24; im-κ, 0.18–0.26). Airway-/emphysema/mixed COPD phenotypes were assigned in 370, 218 and 10 of 583 cases on MRI (347, 218 and 34 of 599 cases on CT; im-κ, 0.63). For all examined features, inter-reader agreement on MRI was lower than on CT. Conclusion: Concordance of MRI and CT for phenotyping of COPD in a multi-centre setting was substantial with variable inter-modality and inter-reader concordance for single diagnostic key features. Clinical relevance statement: MRI of lung morphology may well serve as a radiation-free imaging modality for COPD in scientific and clinical settings, given that its potential and limitations as shown here are carefully considered. | ||
| 650 | 4 | |a Chronic obstructive pulmonary disease | |
| 650 | 4 | |a Computed tomography | |
| 650 | 4 | |a Magnetic resonance imaging | |
| 650 | 4 | |a Pulmonary emphysema | |
| 700 | 1 | |a Pohl, Moritz |d 1991- |e VerfasserIn |0 (DE-588)1203763018 |0 (DE-627)1688817549 |4 aut | |
| 700 | 1 | |a Jobst, Bertram |d 1982- |e VerfasserIn |0 (DE-588)1072564750 |0 (DE-627)827728840 |0 (DE-576)434033766 |4 aut | |
| 700 | 1 | |a Melzig, Claudius |d 1986- |e VerfasserIn |0 (DE-588)1072780445 |0 (DE-627)828231389 |0 (DE-576)434238570 |4 aut | |
| 700 | 1 | |a Meredig, Hagen |d 1984- |e VerfasserIn |0 (DE-588)101336919X |0 (DE-627)664163173 |0 (DE-576)346990475 |4 aut | |
| 700 | 1 | |a Weinheimer, Oliver |d 1973- |e VerfasserIn |0 (DE-588)133803473 |0 (DE-627)556388585 |0 (DE-576)30011558X |4 aut | |
| 700 | 1 | |a Triphan, Simon M. F. |e VerfasserIn |0 (DE-588)1072565080 |0 (DE-627)827729553 |0 (DE-576)434034207 |4 aut | |
| 700 | 1 | |a Stackelberg, Oyunbileg von |e VerfasserIn |0 (DE-588)1071738429 |0 (DE-627)826301487 |0 (DE-576)433285168 |4 aut | |
| 700 | 1 | |a Konietzke, Philip |d 1985- |e VerfasserIn |0 (DE-588)1160331510 |0 (DE-627)1023483874 |0 (DE-576)505856751 |4 aut | |
| 700 | 1 | |a Kauczor, Hans-Ulrich |d 1962- |e VerfasserIn |0 (DE-588)139267123 |0 (DE-627)70327113X |0 (DE-576)310955327 |4 aut | |
| 700 | 1 | |a Heußel, Claus Peter |e VerfasserIn |0 (DE-588)1048631389 |0 (DE-627)780769422 |0 (DE-576)40288146X |4 aut | |
| 700 | 1 | |a Wielpütz, Mark Oliver |d 1982- |e VerfasserIn |0 (DE-588)139999752 |0 (DE-627)614754682 |0 (DE-576)314127046 |4 aut | |
| 700 | 1 | |a Biederer, Jürgen |d 1969- |e VerfasserIn |0 (DE-588)141247282 |0 (DE-627)625830857 |0 (DE-576)322978122 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t European radiology |d Berlin : Springer, 1991 |g 34(2024), 9, Seite 5597-5609 |h Online-Ressource |w (DE-627)268757526 |w (DE-600)1472718-3 |w (DE-576)103868070 |x 1432-1084 |7 nnas |a Phenotyping of COPD with MRI in comparison to same-day CT in a multi-centre trial |
| 773 | 1 | 8 | |g volume:34 |g year:2024 |g number:9 |g pages:5597-5609 |g extent:13 |a Phenotyping of COPD with MRI in comparison to same-day CT in a multi-centre trial |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00330-024-10610-0 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20240612 | ||
| 993 | |a Article | ||
| 994 | |a 2024 | ||
| 998 | |g 141247282 |a Biederer, Jürgen |m 141247282:Biederer, Jürgen |d 910000 |d 911400 |e 910000PB141247282 |e 911400PB141247282 |k 0/910000/ |k 1/910000/911400/ |p 13 |y j | ||
| 998 | |g 139999752 |a Wielpütz, Mark Oliver |m 139999752:Wielpütz, Mark Oliver |d 910000 |d 911400 |d 50000 |e 910000PW139999752 |e 911400PW139999752 |e 50000PW139999752 |k 0/910000/ |k 1/910000/911400/ |k 0/50000/ |p 12 | ||
| 998 | |g 1048631389 |a Heußel, Claus Peter |m 1048631389:Heußel, Claus Peter |d 910000 |d 950000 |d 950900 |d 50000 |e 910000PH1048631389 |e 950000PH1048631389 |e 950900PH1048631389 |e 50000PH1048631389 |k 0/910000/ |k 1/910000/950000/ |k 2/910000/950000/950900/ |k 0/50000/ |p 11 | ||
| 998 | |g 139267123 |a Kauczor, Hans-Ulrich |m 139267123:Kauczor, Hans-Ulrich |d 910000 |d 911400 |e 910000PK139267123 |e 911400PK139267123 |k 0/910000/ |k 1/910000/911400/ |p 10 | ||
| 998 | |g 1160331510 |a Konietzke, Philip |m 1160331510:Konietzke, Philip |d 910000 |d 911400 |d 50000 |e 910000PK1160331510 |e 911400PK1160331510 |e 50000PK1160331510 |k 0/910000/ |k 1/910000/911400/ |k 0/50000/ |p 9 | ||
| 998 | |g 1071738429 |a Stackelberg, Oyunbileg von |m 1071738429:Stackelberg, Oyunbileg von |d 910000 |d 911400 |e 910000PS1071738429 |e 911400PS1071738429 |k 0/910000/ |k 1/910000/911400/ |p 8 | ||
| 998 | |g 1072565080 |a Triphan, Simon M. F. |m 1072565080:Triphan, Simon M. F. |d 910000 |d 911400 |e 910000PT1072565080 |e 911400PT1072565080 |k 0/910000/ |k 1/910000/911400/ |p 7 | ||
| 998 | |g 133803473 |a Weinheimer, Oliver |m 133803473:Weinheimer, Oliver |d 910000 |d 911400 |e 910000PW133803473 |e 911400PW133803473 |k 0/910000/ |k 1/910000/911400/ |p 6 | ||
| 998 | |g 101336919X |a Meredig, Hagen |m 101336919X:Meredig, Hagen |d 910000 |d 911100 |e 910000PM101336919X |e 911100PM101336919X |k 0/910000/ |k 1/910000/911100/ |p 5 | ||
| 998 | |g 1072780445 |a Melzig, Claudius |m 1072780445:Melzig, Claudius |d 910000 |d 911400 |e 910000PM1072780445 |e 911400PM1072780445 |k 0/910000/ |k 1/910000/911400/ |p 4 | ||
| 998 | |g 1072564750 |a Jobst, Bertram |m 1072564750:Jobst, Bertram |d 50000 |e 50000PJ1072564750 |k 0/50000/ |p 3 | ||
| 998 | |g 1203763018 |a Pohl, Moritz |m 1203763018:Pohl, Moritz |p 2 | ||
| 998 | |g 120158163X |a Nauck, Sebastian |m 120158163X:Nauck, Sebastian |d 910000 |d 911400 |e 910000PN120158163X |e 911400PN120158163X |k 0/910000/ |k 1/910000/911400/ |p 1 |x j | ||
| 999 | |a KXP-PPN1891107089 |e 4536697993 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"language":["eng"],"physDesc":[{"noteIll":"Illustrationen","extent":"13 S."}],"origin":[{"dateIssuedKey":"2024","dateIssuedDisp":"12 February 2024"}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"id":{"doi":["10.1007/s00330-024-10610-0"],"eki":["1891107089"]},"person":[{"role":"aut","family":"Nauck","display":"Nauck, Sebastian","roleDisplay":"VerfasserIn","given":"Sebastian"},{"role":"aut","family":"Pohl","roleDisplay":"VerfasserIn","display":"Pohl, Moritz","given":"Moritz"},{"role":"aut","family":"Jobst","display":"Jobst, Bertram","roleDisplay":"VerfasserIn","given":"Bertram"},{"given":"Claudius","display":"Melzig, Claudius","roleDisplay":"VerfasserIn","role":"aut","family":"Melzig"},{"given":"Hagen","roleDisplay":"VerfasserIn","display":"Meredig, Hagen","role":"aut","family":"Meredig"},{"given":"Oliver","display":"Weinheimer, Oliver","roleDisplay":"VerfasserIn","role":"aut","family":"Weinheimer"},{"role":"aut","family":"Triphan","display":"Triphan, Simon M. F.","roleDisplay":"VerfasserIn","given":"Simon M. F."},{"role":"aut","family":"Stackelberg","display":"Stackelberg, Oyunbileg von","roleDisplay":"VerfasserIn","given":"Oyunbileg von"},{"role":"aut","family":"Konietzke","given":"Philip","roleDisplay":"VerfasserIn","display":"Konietzke, Philip"},{"role":"aut","family":"Kauczor","given":"Hans-Ulrich","display":"Kauczor, Hans-Ulrich","roleDisplay":"VerfasserIn"},{"given":"Claus Peter","roleDisplay":"VerfasserIn","display":"Heußel, Claus Peter","family":"Heußel","role":"aut"},{"family":"Wielpütz","role":"aut","given":"Mark Oliver","roleDisplay":"VerfasserIn","display":"Wielpütz, Mark Oliver"},{"given":"Jürgen","roleDisplay":"VerfasserIn","display":"Biederer, Jürgen","role":"aut","family":"Biederer"}],"recId":"1891107089","relHost":[{"note":["Gesehen am 06.02.2018","Ungezählte Beil.: Supplement"],"recId":"268757526","corporate":[{"role":"isb","display":"European Association of Radiology","roleDisplay":"Herausgebendes Organ"}],"origin":[{"publisher":"Springer","dateIssuedDisp":"1991-","publisherPlace":"Berlin ; Heidelberg","dateIssuedKey":"1991"}],"type":{"bibl":"periodical","media":"Online-Ressource"},"disp":"Phenotyping of COPD with MRI in comparison to same-day CT in a multi-centre trialEuropean radiology","title":[{"subtitle":"official organ of the European Association of Radiology","title_sort":"European radiology","title":"European radiology"}],"pubHistory":["1.1991 -"],"id":{"eki":["268757526"],"zdb":["1472718-3"],"issn":["1432-1084","1613-3757"]},"titleAlt":[{"title":"European radiology / Supplement"},{"title":"European radiology supplements"}],"physDesc":[{"extent":"Online-Ressource"}],"part":{"year":"2024","volume":"34","extent":"13","issue":"9","pages":"5597-5609","text":"34(2024), 9, Seite 5597-5609"},"language":["eng"]}],"title":[{"title":"Phenotyping of COPD with MRI in comparison to same-day CT in a multi-centre trial","title_sort":"Phenotyping of COPD with MRI in comparison to same-day CT in a multi-centre trial"}],"name":{"displayForm":["Sebastian Nauck, Moritz Pohl, Bertram J. Jobst, Claudius Melzig, Hagen Meredig, Oliver Weinheimer, Simon Triphan, Oyunbileg von Stackelberg, Philip Konietzke, Hans-Ulrich Kauczor, Claus P. Heußel, Mark O. Wielpütz, Jürgen Biederer and on behalf of the COSYCONET Study Group"]},"note":["Gesehen am 12.06.2024"]} | ||
| SRT | |a NAUCKSEBASPHENOTYPIN1220 | ||