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Bioinspired engineering of fusogen and targeting moiety equipped nanovesicles

Cell-derived small extracellular vesicles have been exploited as potent drug vehicles. However, significant challenges hamper their clinical translation, including inefficient cytosolic delivery, poor target-specificity, low yield, and inconsistency in production. Here, we report a bioinspired mater...

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Main Authors: Wang, Lixue (Author) , Wang, Guosheng (Author) , Mao, Wenjun (Author) , Chen, Yundi (Author) , Rahman, Md Mofizur (Author) , Zhu, Chuandong (Author) , Prisinzano, Peter M. (Author) , Kong, Bo (Author) , Wang, Jing (Author) , Lee, Luke P. (Author) , Wan, Yuan (Author)
Format: Article (Journal)
Language:English
Published: 08 June 2023
In: Nature Communications
Year: 2023, Volume: 14, Pages: 1-12
ISSN:2041-1723
DOI:10.1038/s41467-023-39181-2
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/s41467-023-39181-2
Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/s41467-023-39181-2
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Author Notes:Lixue Wang, Guosheng Wang, Wenjun Mao, Yundi Chen, Md Mofizur Rahman, Chuandong Zhu, Peter M. Prisinzano, Bo Kong, Jing Wang, Luke P. Lee & Yuan Wan
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Summary:Cell-derived small extracellular vesicles have been exploited as potent drug vehicles. However, significant challenges hamper their clinical translation, including inefficient cytosolic delivery, poor target-specificity, low yield, and inconsistency in production. Here, we report a bioinspired material, engineered fusogen and targeting moiety co-functionalized cell-derived nanovesicle (CNV) called eFT-CNV, as a drug vehicle. We show that universal eFT-CNVs can be produced by extrusion of genetically modified donor cells with high yield and consistency. We demonstrate that bioinspired eFT-CNVs can efficiently and selectively bind to targets and trigger membrane fusion, fulfilling endo-lysosomal escape and cytosolic drug delivery. We find that, compared to counterparts, eFT-CNVs significantly improve the treatment efficacy of drugs acting on cytosolic targets. We believe that our bioinspired eFT-CNVs will be promising and powerful tools for nanomedicine and precision medicine.
Item Description:Gesehen am 13.06.2024
Physical Description:Online Resource
ISSN:2041-1723
DOI:10.1038/s41467-023-39181-2

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