Bioinspired engineering of fusogen and targeting moiety equipped nanovesicles
Cell-derived small extracellular vesicles have been exploited as potent drug vehicles. However, significant challenges hamper their clinical translation, including inefficient cytosolic delivery, poor target-specificity, low yield, and inconsistency in production. Here, we report a bioinspired mater...
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| Hauptverfasser: | , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
08 June 2023
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| In: |
Nature Communications
Year: 2023, Jahrgang: 14, Pages: 1-12 |
| ISSN: | 2041-1723 |
| DOI: | 10.1038/s41467-023-39181-2 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/s41467-023-39181-2 Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/s41467-023-39181-2 
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| Verfasserangaben: | Lixue Wang, Guosheng Wang, Wenjun Mao, Yundi Chen, Md Mofizur Rahman, Chuandong Zhu, Peter M. Prisinzano, Bo Kong, Jing Wang, Luke P. Lee & Yuan Wan |
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| 520 | |a Cell-derived small extracellular vesicles have been exploited as potent drug vehicles. However, significant challenges hamper their clinical translation, including inefficient cytosolic delivery, poor target-specificity, low yield, and inconsistency in production. Here, we report a bioinspired material, engineered fusogen and targeting moiety co-functionalized cell-derived nanovesicle (CNV) called eFT-CNV, as a drug vehicle. We show that universal eFT-CNVs can be produced by extrusion of genetically modified donor cells with high yield and consistency. We demonstrate that bioinspired eFT-CNVs can efficiently and selectively bind to targets and trigger membrane fusion, fulfilling endo-lysosomal escape and cytosolic drug delivery. We find that, compared to counterparts, eFT-CNVs significantly improve the treatment efficacy of drugs acting on cytosolic targets. We believe that our bioinspired eFT-CNVs will be promising and powerful tools for nanomedicine and precision medicine. | ||
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| 700 | 1 | |a Wan, Yuan |e VerfasserIn |4 aut | |
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